This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Gardasil 9
Generic Name
Human papillomavirus type 45 L1 capsid protein antigen
DrugBank Accession Number
DB10312
Background

Human papillomavirus type 45 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 45. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Type 45 which are produced by separate fermentations in recombinant Saccharomyces cerevisiae and self-assembled into VLPs.

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Other vaccines
Synonyms
  • L1 protein, Human papillomavirus type 45 Vaccine
  • Recombinant human papillomavirus type 45 L1 protein

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products2
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)Injection, suspensionIntramuscularMsd Vaccins2021-02-09Not applicableEU flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 16 L1 capsid protein antigen (60 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2014-12-10Not applicableUS flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)Injection, suspensionIntramuscularMsd Vaccins2021-02-09Not applicableEU flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 16 L1 capsid protein antigen (60 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2014-12-10Not applicableUS flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)Injection, suspensionIntramuscularMsd Vaccins2020-12-18Not applicableEU flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)Injection, suspensionIntramuscularMsd Vaccins2021-02-09Not applicableEU flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 16 L1 capsid protein antigen (60 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2014-12-10Not applicableUS flag
Gardasil 9Human papillomavirus type 45 L1 capsid protein antigen (20 mcg / 0.5 mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg / 0.5 mL) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg / 0.5 mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg / 0.5 mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg / 0.5 mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg / 0.5 mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg / 0.5 mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg / 0.5 mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg / 0.5 mL)SuspensionIntramuscularMerck Ltd.2015-03-18Not applicableCanada flag
GARDASİL 9 IM ENJEKSİYONLUK SÜSPANSİYON, 1 ADET ŞIRINGA+2 ADET İĞNEHuman papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)Injection, solutionIntramuscularMERCK SHARP DOHME İLAÇLARI LTD. ŞTİ.2020-08-14Not applicableTurkey flag
GARDASIL 9 SUSPENSION FOR INJECTIONHuman papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)Injection, suspensionIntramuscularMSD PHARMA (SINGAPORE) PTE. LTD.2016-12-16Not applicable

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
68S8VCN34F
CAS number
Not Available

References

General References
Not Available
PubChem Substance
347910491
RxNav
1596932

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingPreventionAllogeneic Hematopoietic Stem Cell Transplant Recipient / Hematopoietic and Lymphoid Cell Neoplasm1
4Active Not RecruitingPreventionHuman Papilloma Virus-Related Cervical Carcinoma / Human Papillomavirus Infections1
4Active Not RecruitingPreventionPapillomavirus Infections1
4Not Yet RecruitingPreventionHuman Immunodeficiency Virus (HIV) Infections1
4RecruitingBasic ScienceHuman Papilloma Virus (HPV)1
4RecruitingPreventionCoronavirus Disease 2019 (COVID‑19) / Human Papillomavirus Infections1
4RecruitingPreventionPapilloma Viral Infection1
4RecruitingPreventionPapillomavirus Vaccines1
4RecruitingTreatmentHigh Grade Anal Canal Intraepithelial Neoplasia / Vulvar High Grade Squamous Intraepithelial Lesion (HSIL)1
3CompletedPreventionHPV Vaccines Immunogenicity and Safety1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, suspensionIntramuscular
Injection, suspensionIntramuscular; Parenteral
Injection, solutionIntramuscular
Injection, suspensionIntramuscular40 mcg
SuspensionIntramuscular
Injection, suspension
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at December 01, 2015 20:03 / Updated at February 13, 2021 10:52