NCT00613171
Efficacy and Tolerability of STI571 (Imatinib Mesylate) for the Treatment of Fibrosis in Participants With Systemic Sclerosis treatment 2 completed NCT00226889
Treatment of Early Systemic Sclerosis by Bosentan treatment 1 / 2 terminated NCT06646913
TENS in Scleroderma No drug interventions device_feasibility 1 recruiting NCT06647069
DR-0201 in Subjects With Autoimmune Diseases No drug interventions treatment 1 not_yet_recruiting NCT05995626
Hyaluronidase Via LADD Scleroderma-induced Microstomia treatment 0 recruiting NCT04567537
Laser Treatment for the Improvement of Scars and Scleroderma No drug interventions treatment Not Available active_not_recruiting NCT06195072
Platform Clinical Study for Conquering Scleroderma treatment 2 recruiting NCT06373263
Evaluating Tools to Communicate Scleroderma Research Results to Patients No drug interventions other Not Available not_yet_recruiting NCT04797286
Sildenafil for Early Pulmonary Vascular Disease in Scleroderma treatment 2 recruiting NCT05925803
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY) treatment 3 recruiting NCT06328777
RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis No drug interventions treatment 1 / 2 recruiting NCT06587828
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients with Autoimmune Disease No drug interventions Not Available Not Available recruiting NCT06588959
6-minute Pegboard Ring Test in Patients with Scleroderma No drug interventions Not Available Not Available not_yet_recruiting NCT06598982
Investigation of Respiratory Muscle Sarcopenia in Patients with Systemic Sclerosis No drug interventions Not Available Not Available recruiting NCT05785403
Co-designing Digital Ulcers Opportunities With Patients and Clinicians No drug interventions Not Available Not Available not_yet_recruiting NCT01553890
Empirical Comparative Study of Variation Blood Level Antibody Vitamin D at Scleroderma (SSc) Patients Compared Healthy Peoples No drug interventions diagnostic Not Available unknown_status NCT01570764
Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease treatment 3 completed NCT05204784
Rheopheresis for Raynaud's and Digital Ulcers in Systemic Sclerosis No drug interventions treatment Not Available unknown_status NCT01656447
Scleroderma Registry & Repository at the Hospital for Special Surgery No drug interventions Not Available Not Available recruiting NCT01117298
A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma treatment 3 completed NCT03726398
CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH prevention 2 / 3 unknown_status NCT00372398
Premature Coronary Atherosclerosis in Scleroderma No drug interventions Not Available Not Available completed NCT00476697
UVA1 Light for Scleroderma and Similar Conditions No drug interventions treatment Not Available terminated NCT00930683
A Study to Evaluate Safety and Tolerability of Multiple Doses of MEDI-546 in Adult Subjects With Scleroderma treatment 1 completed NCT03508661
The Scleroderma Patient-centered Intervention Network (SPIN) Support Group Leader Education Program Feasibility Trial No drug interventions supportive_care Not Available completed NCT02370693
Comparing and Combining Bortezomib and Mycophenolate in SSc Pulmonary Fibrosis treatment 2 completed NCT02733978
Ozone Therapy in the Treatment of Digital Ulcers in Patients With Systemic Sclerosis No drug interventions treatment Not Available completed NCT04875078
UVA-1 for Treatment of Skin Tightening and Improvement of Hand Function in Scleroderma No drug interventions treatment Not Available enrolling_by_invitation NCT04610788
Cardiac Assessment by PV Loop in IPAH and Scleroderma PAH No drug interventions Not Available Not Available recruiting NCT03937856
Smartphone Mindfulness Meditation for Patients With Rheumatic Diseases No drug interventions treatment Not Available terminated NCT00740285
Effectiveness and Safety of Lidocaine for Scleroderma No drug interventions treatment 2 / 3 completed NCT05251415
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases No drug interventions Not Available Not Available recruiting NCT05168215
Effectiveness of Bosentan Therapy in Patients With Systemic scleRosis and Progressive Digital ulcEr Disease. No drug interventions Not Available Not Available recruiting NCT06554132
Respiratory Muscle Strength and Aerobic Capacity in Scleroderma No drug interventions Not Available Not Available recruiting NCT02302352
Effects of Probiotics on Gastrointestinal Symptoms and on the Immune System in Patients With Systemic Sclerosis No drug interventions treatment 3 unknown_status NCT00005675
Oral Type I Collagen for Relieving Scleroderma treatment 2 completed NCT00946699
A Study of the Safety and Tolerability of MEDI-551 in Scleroderma treatment 1 completed NCT01642706
Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments No drug interventions Not Available Not Available unknown_status NCT00043706
Safety, Tolerability, and Pharmacokinetics of CAT-192 (Human Anti-TGF-Beta1 Monoclonal Antibody) in Patients With Early Stage Diffuse Systemic Sclerosis No drug interventions treatment 1 / 2 completed NCT00377949
Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients No drug interventions Not Available Not Available completed NCT01538719
IL1-TRAP, Rilonacept, in Systemic Sclerosis treatment 1 / 2 completed NCT00419419
Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud's Phenomenon treatment 3 completed NCT02680717
Comparative Effectiveness Trial in the Treatment of Pediatric Plaque Morphea treatment 1 withdrawn NCT02835196
Optical Elastography of Systemic Sclerosis Skin No drug interventions Not Available Not Available completed NCT04491396
Yoga Adjunct for Scleroderma No drug interventions treatment Not Available active_not_recruiting NCT00775463
Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine treatment 2 completed NCT01111786
Finger Hardness Measure in Scleroderma No drug interventions Not Available Not Available completed NCT04273386
Mouth Handicap in Systemic Sclerosis No drug interventions other Not Available completed NCT03270722
Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing No drug interventions diagnostic Not Available withdrawn NCT03141125
The Effect of Ethanol Extract Physalis Angulata Linn. in Scleroderma Patients With Standard Therapy No drug interventions treatment Not Available completed NCT02588625
A Double-Blinded Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986020 Versus Placebo in Diffuse Cutaneous Systemic Sclerosis (dcSSc) treatment 2 withdrawn NCT00282425
Allogeneic Hematopoietic Stem Cell Transplantation (NST) for Patients With Systemic Sclerosis No drug interventions treatment 1 terminated NCT03411057
Mindfulness Based Stress Reduction in Rheumatic Diseases No drug interventions Not Available Not Available terminated NCT06339957
Rheumatology Diet Study No drug interventions Not Available Not Available recruiting NCT01878526
Gastroesophageal Reflux Treatment in Scleroderma treatment 3 completed NCT05635266
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives No drug interventions Not Available Not Available recruiting NCT03742466
Local Injection of Ozone Versus Methylprednisolone Acetate in Carpal Tunnel Syndrome of Scleroderma Patients treatment Not Available completed NCT01374282
Post Marketing Surveillance Study of Cuprimine Not Available Not Available no_longer_available NCT01639573
Campath-1h Phase I/II Pilot Trial as Immunoablative Therapy for Refractory Systemic Sclerosis Not Available Not Available withdrawn NCT01545427
Proof of Concept Trial of Gleevec (Imatinib) in Active Diffuse Scleroderma treatment 2 terminated NCT03274076
Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc) treatment 1 / 2 completed NCT05236491
COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases No drug interventions prevention 2 / 3 recruiting NCT00513591
Duke Autoimmunity in Pregnancy Registry No drug interventions Not Available Not Available completed NCT02166229
Divalproex Sodium in the Treatment of the Cutaneous Manifestations of Scleroderma treatment 1 / 2 withdrawn NCT00883129
Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II) treatment 2 completed NCT04179292
The Effect of Physiotherapy Program in Scleroderma Patients No drug interventions treatment Not Available completed NCT05181644
Effectiveness of the EmoLED Medical Device in the Healing of Digital Ulcers in Patients With Scleroderma. No drug interventions treatment Not Available terminated NCT05085444
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma No drug interventions treatment 0 recruiting NCT05098704
Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk treatment 2 / 3 recruiting NCT05041868
Rehabilitation Program in Patients With Scleroderma No drug interventions treatment Not Available recruiting NCT02887495
The Scleroderma Biorepository and Pathogenesis Study (STOP Scleroderma) No drug interventions Not Available Not Available completed NCT04588714
Feasibility and Preliminary Effects of the Resilience-based, Energy Management to Enhance Wellbeing in Systemic Sclerosis (RENEW) Intervention No drug interventions supportive_care Not Available completed NCT05204355
MRI for Screening and Monitoring Scleroderma ILD No drug interventions Not Available Not Available recruiting NCT02798055
Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis Not Available Not Available completed NCT03276923
Maternal Autoimmune Disease Research Alliance (MADRA) Registry No drug interventions Not Available Not Available recruiting NCT05080738
Upper Extremity Home Exercises in Patients With Scleroderma No drug interventions treatment Not Available completed NCT04908943
RENEW Scleroderma: A Peer-Mentored, Web Intervention for Resilience-based, Energy Management to Enhance Wellbeing and Fatigue No drug interventions supportive_care Not Available completed NCT06095921
The Effect of a Self-Management Program on Individuals With Scleroderma No drug interventions treatment Not Available completed NCT03593902
Cardiac Safe Transplants for Systemic Sclerosis treatment 2 / 3 terminated NCT04481984
Effectiveness of a Home-based, Self-administered Exercise Program for Hands in Patients With Systemic Sclerosis No drug interventions treatment Not Available completed NCT02370784
Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma treatment 2 completed NCT04335279
Evaluation of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together Program No drug interventions supportive_care Not Available completed NCT00319033
Open-label Study With Bosentan in Interstitial Lung Disease treatment 2 / 3 completed NCT03560154
Effects of Whole Body Vibration Training in Patients With Interstitial Lung Disease No drug interventions treatment Not Available unknown_status NCT00040651
Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients treatment 1 terminated NCT04535245
Lung Clearance Index to Identify Scleroderma Patients at Risk for ILD No drug interventions Not Available Not Available recruiting NCT02896205
Study to Compare the Efficacy of Mycophenolate Mofetil in Systemic Sclerosis Related Early Interstitial Lung Disease treatment 3 completed NCT03207997
MRI Quantification of Pulmonary Fibrosis in Scleroderma Patients No drug interventions diagnostic Not Available completed NCT03840928
PatientSpot Formerly Known as ArthritisPower No drug interventions Not Available Not Available recruiting NCT04246528
SPIN Self-Management Feasibility Trial With Progression to Full-scale Trial (SPIN-SELF) No drug interventions supportive_care Not Available recruiting NCT02165111
Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's Syndrome treatment 3 completed NCT02240888
Vaccination in Inflammatory Rheumatic Disease (VACCIMIL). The Impact of Antirheumatic Treatment on Antibody Response No drug interventions treatment Not Available completed NCT00764309
Safety Evaluation of Dasatinib in Subjects With Scleroderma Pulmonary Fibrosis treatment 1 / 2 completed NCT01093885
Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis treatment Not Available completed NCT01959815
Novel Screening Strategies for Scleroderma PAH No drug interventions Not Available Not Available completed NCT00498615
A Rho-kinase Inhibitor (Fasudil) in the Treatment of Raynaud's Phenomenon treatment 3 completed NCT00566137
Sleep Disturbances and Pulmonary Artery/Aorta Diameter in Scleroderma Patient No drug interventions Not Available Not Available completed NCT05870852
Effectiveness of ESWT and PNF in Scleroderma With Calcinosis No drug interventions treatment Not Available not_yet_recruiting NCT02851875
Duke Scleroderma Clinic Patient Registry No drug interventions Not Available Not Available terminated NCT02610842
Hands on - a Hand Care Guide in Systemic Sclerosis No drug interventions treatment Not Available completed NCT04523506
The Effects of Botulinum Toxin on Oral Aperture in Patients With Scleroderma treatment 0 completed NCT02837549
Novel Rehabilitation Strategies to Improve Arm Function in Patients With Scleroderma No drug interventions treatment Not Available completed NCT01762449
Morbidity and Mortality Follow Up for the Scleroderma Lung Study No drug interventions Not Available Not Available completed NCT04746313
Prevalence of Hyperprolactinemia in Systemic Scleroderma No drug interventions Not Available Not Available recruiting NCT03800017
Skeletal Muscle Function in Interstitial Lung Disease No drug interventions basic_science Not Available not_yet_recruiting NCT04464434
Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis No drug interventions treatment 4 recruiting NCT03092024
Scleroderma Patient-centered Intervention Network (SPIN) Hand Program Feasibility Study No drug interventions supportive_care Not Available completed NCT03740724
A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea) treatment 1 / 2 terminated NCT03294616
Transcutaneous Electroacupuncture for Gastric Complications of Scleroderma No drug interventions treatment Not Available completed NCT04178616
Assessment of the Prevalence of Olfactory Disorders in Systemic Scleroderma No drug interventions diagnostic Not Available terminated NCT03459716
Endothelial Biomarkers of Systemic Sclerosis-associated Pulmonary Hypertension No drug interventions Not Available Not Available unknown_status NCT04966416
Calcinosis Reduction by Pyrophosphate in SSC No drug interventions treatment Not Available not_yet_recruiting NCT02450396
Pregnancy and Medically Assisted Conception in Rare Diseases No drug interventions Not Available Not Available recruiting NCT02915835
Riociguat in Scleroderma Associated Digital Ulcers treatment 2 completed NCT00204763
Comparison of Esophageal and Anorectal Manometry Catheters No drug interventions diagnostic 4 terminated NCT04402086
Rheumatology Patient Registry and Biorepository No drug interventions Not Available Not Available recruiting NCT00213525
Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Controls No drug interventions Not Available Not Available completed NCT02328625
Scleroderma Treatment With Celution Processed ADRCs Registry No drug interventions Not Available Not Available withdrawn NCT02062125
Calcinosis in a Single-Center Scleroderma Population No drug interventions Not Available Not Available completed NCT04684225
Telerehabilitation on Hand-Affected Scleroderma No drug interventions treatment Not Available completed NCT02331225
Endothelial Microparticles in Systemic Sclerosis Pulmonary Hypertension No drug interventions Not Available Not Available completed NCT05963048
Rituxmab Versus IL-6 in Treating ILD treatment 2 / 3 completed NCT01862926
Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD treatment 2 / 3 completed NCT00540566
Optical Biopsy of Human Skin in Conjunction With Laser Treatment No drug interventions Not Available Not Available completed NCT05617066
Stress, Scleroderma and Quality of Life No drug interventions other Not Available completed NCT02006420
Scleroderma ARFI Imaging of the Skin No drug interventions Not Available Not Available completed NCT04630782
Evaluating Gut Imaging and Stool Biomarkers in Patients With Scleroderma-associated Gastrointestinal Disease No drug interventions Not Available Not Available unknown_status NCT04837131
A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients treatment 2 terminated NCT02426229
Safety & Suitability of Dabigatran to Inhibit Thrombin in Scleroderma treatment 1 completed NCT06264492
Delving Into Participation Trends of Scleroderma Clinical Trials No drug interventions Not Available Not Available not_yet_recruiting NCT03222492
Brentuximab Vedotin for Systemic Sclerosis treatment 1 / 2 completed NCT01931644
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions No drug interventions Not Available Not Available completed NCT04265144
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre No drug interventions other Not Available recruiting NCT01895244
Autologous Stem Cell Transplantation for Progressive Systemic Sclerosis No drug interventions treatment 2 completed NCT00007267
Psychological Treatments for Scleroderma No drug interventions treatment 2 completed NCT02494401
Taking Charge of Systemic Sclerosis No drug interventions other Not Available completed NCT00476801
UVA1 Light for Treatment of Scleroderma and Similar Conditions No drug interventions treatment Not Available completed NCT04656704
Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease treatment 0 withdrawn NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford No drug interventions Not Available Not Available recruiting NCT00074568
Scleroderma Registry No drug interventions Not Available Not Available completed NCT06474910
Connective Tissue Massage in Scleroderma No drug interventions treatment Not Available recruiting NCT04563481
Effectiveness of Telerehabilitation on Scleroderma No drug interventions treatment Not Available unknown_status NCT03914781
SPIN Self-Management Feasibility Trial No drug interventions supportive_care Not Available completed NCT00501995
High Dose Cyclophosphamide for Treatment of Scleroderma treatment 3 completed NCT06536595
Validity and Reliability of the Turkish Version of HAnDE No drug interventions Not Available Not Available completed NCT03419208
Scleroderma Patient-centered Intervention Network (SPIN) Hand Program No drug interventions supportive_care Not Available completed NCT02047708
Zibotentan Better Renal Scleroderma Outcome Study treatment 2 completed NCT02396238
Scleroderma Treatment With Celution Processed Adipose Derived Regenerative Cells (STAR) No drug interventions treatment Not Available completed NCT01497743
Probiotics in Patients With Moderate-to-severe Distention/ Bloating From Systemic Sclerosis treatment 4 withdrawn