m-Chlorophenylpiperazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
m-Chlorophenylpiperazine
DrugBank Accession Number
DB12110
Background

m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 196.677
Monoisotopic: 196.076726133
Chemical Formula
C10H13ClN2
Synonyms
  • 1-(3-chlorophenyl)piperazine
  • M-CPP
  • MCPP
External IDs
  • J227.960F
  • NSC-49307

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
U5-hydroxytryptamine receptor 2C
agonist
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

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Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of adverse effects can be increased when m-Chlorophenylpiperazine is combined with 1,2-Benzodiazepine.
AcenocoumarolThe risk or severity of adverse effects can be increased when m-Chlorophenylpiperazine is combined with Acenocoumarol.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with m-Chlorophenylpiperazine.
AcetophenazineThe risk or severity of adverse effects can be increased when Acetophenazine is combined with m-Chlorophenylpiperazine.
Aclidiniumm-Chlorophenylpiperazine may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with m-Chlorophenylpiperazine.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with m-Chlorophenylpiperazine.
AlimemazineThe risk or severity of adverse effects can be increased when Alimemazine is combined with m-Chlorophenylpiperazine.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with m-Chlorophenylpiperazine.
AlosetronThe risk or severity of adverse effects can be increased when Alosetron is combined with m-Chlorophenylpiperazine.
Interactions
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Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
m-Chlorophenylpiperazine dihydrochlorideMY02G3EAXQ51639-49-7OSZCTRWSGNWWBL-UHFFFAOYSA-N
m-Chlorophenylpiperazine hydrochloride7IM2GS7ILV13078-15-4MHXPYWFZULXYHT-UHFFFAOYSA-N

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazinanes
Sub Class
Piperazines
Direct Parent
Phenylpiperazines
Alternative Parents
N-arylpiperazines / Dialkylarylamines / Aniline and substituted anilines / Chlorobenzenes / Aryl chlorides / Dialkylamines / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Hydrocarbon derivatives
Substituents
Amine / Aniline or substituted anilines / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Benzenoid / Chlorobenzene / Dialkylarylamine / Halobenzene
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
N-arylpiperazine, monochlorobenzenes (CHEBI:10588)
Affected organisms
Not Available

Chemical Identifiers

UNII
REY0CNO998
CAS number
6640-24-0
InChI Key
VHFVKMTVMIZMIK-UHFFFAOYSA-N
InChI
InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
IUPAC Name
1-(3-chlorophenyl)piperazine
SMILES
ClC1=CC(=CC=C1)N1CCNCC1

References

General References
Not Available
Human Metabolome Database
HMDB0061008
KEGG Compound
C11738
PubChem Compound
1355
PubChem Substance
347828411
ChemSpider
1314
BindingDB
50001915
ChEBI
10588
ChEMBL
CHEMBL478
ZINC
ZINC000000004285

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentAlcohol Dependency1
2CompletedTreatmentCocaine Related Disorders1
1CompletedTreatmentCocaine Related Disorders1
Not AvailableTerminatedBasic ScienceBMI >30 kg/m2 / Eating Behavior1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility3.12 mg/mLALOGPS
logP2.07ALOGPS
logP2.15ChemAxon
logS-1.8ALOGPS
pKa (Strongest Basic)8.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area15.27 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity56.05 m3·mol-1ChemAxon
Polarizability20.87 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0900000000-a6d6490a377499574773
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0002-0900000000-dacdc382bd4b60551efd
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0002-0900000000-c498b22640780e85d0c5
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0002-0900000000-6188e12d6302f0aac6ad
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udj-0900000000-0307be5cc27e8b5e3d6e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0uxr-0900000000-4f1ffdc6559ba8ef8ab0
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0gb9-0900000000-ffa868d7cd2f5dd55b0a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0002-0900000000-036e27cc7151ed5587e2
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0002-0900000000-cf09b776cfded257a89e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0002-0900000000-8119dafe7571a20d6ce8
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udj-0900000000-0826be5530cb871f3576
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0uxr-0900000000-a55042eda43832b42f68
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0gb9-0900000000-c3dd0b695bc65a727bf0
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0900000000-ce6c9c7155861aeb31be
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0gb9-0900000000-04b37011a6b6e19ca424
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-014i-1900000000-5ea27eb4735ba042f7d9
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0002-0900000000-04afb01877e4cfc97762
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0002-0900000000-2391d33f985d617108cf
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0f6t-0900000000-46eb898a4634d282ad5d

Targets

Drugtargets
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
General Function
Serotonin receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-...
Gene Name
HTR2C
Uniprot ID
P28335
Uniprot Name
5-hydroxytryptamine receptor 2C
Molecular Weight
51820.705 Da
References
  1. Gibson EL, Barnfield AM, Curzon G: Evidence that mCPP-induced anxiety in the plus-maze is mediated by postsynaptic 5-HT2C receptors but not by sympathomimetic effects. Neuropharmacology. 1994 Mar-Apr;33(3-4):457-65. [Article]

Drug created on October 20, 2016 21:22 / Updated on June 12, 2020 16:53