This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Clorindione
- DrugBank Accession Number
- DB13275
- Background
Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Clorindione (DB13275)
- Weight
- Average: 256.69
Monoisotopic: 256.0291072 - Chemical Formula
- C15H9ClO2
- Synonyms
- Clorindione
- External IDs
- G-25766
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of bleeding can be increased when Abciximab is combined with Clorindione. Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Clorindione. Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Clorindione is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Clorindione. Acetaminophen Acetaminophen may increase the anticoagulant activities of Clorindione. Acetic acid The risk or severity of bleeding can be increased when Acetic acid is combined with Clorindione. Acetohexamide Acetohexamide may increase the anticoagulant activities of Clorindione. Acetyl sulfisoxazole The risk or severity of bleeding can be increased when Acetyl sulfisoxazole is combined with Clorindione. Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Clorindione. Agomelatine The risk or severity of adverse effects can be increased when Agomelatine is combined with Clorindione. 
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- Avoid herbs and supplements with anticoagulant/antiplatelet activity. These may increase anticoagulant/antiplatelet activity of clorindione. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Categories
- ATC Codes
- B01AA09 — Clorindione
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Indanes
- Sub Class
- Indanones
- Direct Parent
- Indanediones
- Alternative Parents
- Aryl alkyl ketones / Chlorobenzenes / Beta-diketones / Aryl chlorides / Organochlorides / Organic oxides / Hydrocarbon derivatives
- Substituents
- 1,3-dicarbonyl compound / 1,3-diketone / Aromatic homopolycyclic compound / Aryl alkyl ketone / Aryl chloride / Aryl halide / Aryl ketone / Chlorobenzene / Halobenzene / Hydrocarbon derivative
- Molecular Framework
- Aromatic homopolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 541C7WS64R
- CAS number
- 1146-99-2
- InChI Key
- NJDUWAXIURWWLN-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H9ClO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H
- IUPAC Name
- 2-(4-chlorophenyl)-2,3-dihydro-1H-indene-1,3-dione
- SMILES
- ClC1=CC=C(C=C1)C1C(=O)C2=CC=CC=C2C1=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 64010
- BindingDB
- 50280162
- ChEBI
- 135057
- ChEMBL
- CHEMBL278519
- ZINC
- ZINC000100003913
- Wikipedia
- Clorindione
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00531 mg/mL ALOGPS logP 3.66 ALOGPS logP 3.48 ChemAxon logS -4.7 ALOGPS pKa (Strongest Acidic) 4.4 ChemAxon pKa (Strongest Basic) -7.5 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 34.14 Å2 ChemAxon Rotatable Bond Count 1 ChemAxon Refractivity 70.04 m3·mol-1 ChemAxon Polarizability 25.63 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:39 / Updated at February 21, 2021 18:54