NAV

Clorindione

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Clorindione
Accession Number
DB13275
Description

Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.

Type
Small Molecule
Groups
Experimental
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Structure
Thumb
3D
Similar Structures
Weight
Average: 256.69
Monoisotopic: 256.0291072
Chemical Formula
C15H9ClO2
Synonyms
Not Available
External IDs
  • G-25766

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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AbametapirThe serum concentration of Clorindione can be increased when it is combined with Abametapir.
AbciximabThe risk or severity of bleeding can be increased when Abciximab is combined with Clorindione.
AceclofenacThe risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Clorindione.
AcemetacinThe risk or severity of bleeding and hemorrhage can be increased when Acemetacin is combined with Clorindione.
AcenocoumarolThe risk or severity of bleeding can be increased when Acenocoumarol is combined with Clorindione.
AcetaminophenAcetaminophen may increase the anticoagulant activities of Clorindione.
Acetic acidThe risk or severity of bleeding can be increased when Acetic acid is combined with Clorindione.
AcetohexamideAcetohexamide may increase the anticoagulant activities of Clorindione.
Acetyl sulfisoxazoleThe risk or severity of bleeding can be increased when Acetyl sulfisoxazole is combined with Clorindione.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Clorindione.
Additional Data Available
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    Evidence Level
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Food Interactions
  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. These may increase anticoagulant/antiplatelet activity of clorindione. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Categories

ATC Codes
B01AA09 — Clorindione
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Indanes
Sub Class
Indanones
Direct Parent
Indanediones
Alternative Parents
Aryl alkyl ketones / Chlorobenzenes / Beta-diketones / Aryl chlorides / Organochlorides / Organic oxides / Hydrocarbon derivatives
Substituents
1,3-dicarbonyl compound / 1,3-diketone / Aromatic homopolycyclic compound / Aryl alkyl ketone / Aryl chloride / Aryl halide / Aryl ketone / Chlorobenzene / Halobenzene / Hydrocarbon derivative
Molecular Framework
Aromatic homopolycyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
541C7WS64R
CAS number
1146-99-2
InChI Key
NJDUWAXIURWWLN-UHFFFAOYSA-N
InChI
InChI=1S/C15H9ClO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H
IUPAC Name
2-(4-chlorophenyl)-2,3-dihydro-1H-indene-1,3-dione
SMILES
ClC1=CC=C(C=C1)C1C(=O)C2=CC=CC=C2C1=O

References

General References
Not Available
ChemSpider
64010
BindingDB
50280162
ChEBI
135057
ChEMBL
CHEMBL278519
ZINC
ZINC000100003913
Wikipedia
Clorindione

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00531 mg/mLALOGPS
logP3.66ALOGPS
logP3.48ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)4.4ChemAxon
pKa (Strongest Basic)-7.5ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity70.04 m3·mol-1ChemAxon
Polarizability25.63 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on June 23, 2017 14:39 / Updated on July 14, 2020 04:58

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