Glutathione S-transferase P

BE0000814ProteinHumansGSTP1

Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1540159, PubMed:1567427, PubMed:8433974). It is acted on by 39 drugs in DrugBank.

Gene name
GSTP1
UniProtKB entry
P09211Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
210 residues · 23,356 Da
Also known as
2.5.1.18 · FAEES3 · GST class-pi · GST3 · GSTP1-1

Resolves to

Protein
UniProtP09211UniProt nameGSTP1_HUMAN
Gene
HGNCHGNC:4638NCBI Gene2950GenBank31946GeneCardsGSTP1
Pharmacology
KEGGhsa:2950
Structure
PDB10GSPDB11GSPDB12GS
Drugs

What you can answer from here — as of September 07, 2019

39DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
2Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
99+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Glutathione S-transferase P, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In