This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Butamirate is a cough suppressant.
- Generic Name
- Butamirate
- DrugBank Accession Number
- DB13731
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Butamirate (DB13731)
- Weight
- Average: 307.434
Monoisotopic: 307.214743798 - Chemical Formula
- C18H29NO3
- Synonyms
- Butamirate
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Coughing •••••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image TUSAMOL 7,5 MG/5 ML SURUP Butamirate (7.5 mg/5ml) Syrup ATABAY KİMYA SAN. VE TİC. A.Ş. 2013-01-29 Not applicable Turkey 
Categories
- ATC Codes
- R05DB13 — Butamirate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Phenylpropanes
- Direct Parent
- Phenylpropanes
- Alternative Parents
- Fatty acid esters / Trialkylamines / Carboxylic acid esters / Amino acids and derivatives / Monocarboxylic acids and derivatives / Dialkyl ethers / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Amine / Amino acid or derivatives / Aromatic homomonocyclic compound / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Dialkyl ether / Ether / Fatty acid ester / Fatty acyl
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- M75MZG2236
- CAS number
- 18109-80-3
- InChI Key
- DDVUMDPCZWBYRA-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H29NO3/c1-4-17(16-10-8-7-9-11-16)18(20)22-15-14-21-13-12-19(5-2)6-3/h7-11,17H,4-6,12-15H2,1-3H3
- IUPAC Name
- 2-[2-(diethylamino)ethoxy]ethyl 2-phenylbutanoate
- SMILES
- CCC(C(=O)OCCOCCN(CC)CC)C1=CC=CC=C1
References
- General References
- AIFA Product Information: Froben Dry Cough (butamirate citrate) for oral use [Link]
- External Links
- ChemSpider
- 26873
- 19862
- ChEBI
- 135310
- ChEMBL
- CHEMBL1332546
- Wikipedia
- Butamirate
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution / drops Oral Syrup Syrup 7.5 mg/5ml Solution / drops Oral 1.3 MG/ML Syrup 1.7 MG/5ML Tablet Transmucosal 50 mg Solution / drops Oral 2 MG/ML Syrup 3 MG/10G Tablet Transmucosal 5 MG Tablet, coated 5 MG Syrup 4 mg/5mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.107 mg/mL ALOGPS logP 3.86 ALOGPS logP 3.43 Chemaxon logS -3.5 ALOGPS pKa (Strongest Basic) 9.41 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.77 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 89.87 m3·mol-1 Chemaxon Polarizability 36.58 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-014i-3900000000-b17b9a5ae8657f12513b Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0uxr-0911000000-e2620bc5d974b41ae19f Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-08fr-7921000000-82351007cf246bcf9636 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0uxr-3900000000-4e624f23837658119f78 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9400000000-bc6833a874f121136e72 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0006-9500000000-449ed7037be719e0be7b Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0frf-8900000000-0ef8b9bcecc71cc92e21 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 172.47636 predictedDeepCCS 1.0 (2019) [M+H]+ 174.83437 predictedDeepCCS 1.0 (2019) [M+Na]+ 180.9275 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:47 / Updated at May 22, 2021 06:01