Fluticasone is a corticosteroid indicated in the treatment of corticosteroid responsive dermatoses, asthma, and COPD. Fluticasone is a synthetic glucocorticoid available as 2 esters, DB08906 and DB00588.
- Mechanism
- Curator reviewed · 8 references
DB08906 and DB00588 work through an unknown mechanism to affect the action of various cell types and mediators of inflammation. In vitro experiments show DB08906 activating glucocorticoid receptors, inhibiting nuclear factor kappa b, and inhibiting lung eosinophilia in rats. DB00588 performs similar activity but is not stated to affect nuclear factor kappa b.
- Primary indication
- Fluticasone's 2 esters are indicated as inhalers for the treatment and management of asthma by prophylaxis as well as inflammatory and pruritic dermatoses.Curator reviewed · 6 structured indications
- Formula / weight
- C22H27F3O4S · 444.51 g/mol (avg)
Resolves to
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Which drugs share a target with Fluticasone, and which of those have an active Phase 3 trial?
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