Concanamycin A

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DB14062ExperimentalSmall molecule

Concanamycin A is an H+-ATPase (vacuolar) inhibitor.

Mechanism: Pharmacologically active on ATP-dependent translocase ABCB1
Curator reviewed
Formula / weight: C₄₆H₇₅NO₁₄ · 866.099 g/mol (avg)
Code names: Antibiotic X 4357 B · X 4357 B

Resolves to

Compound

CAS80890-47-7ChEMBLCHEMBL1241239ChEBI73167

Structure

InChIKeyDJZCTUVALDDONK-HQMSUKCRSA-NSMILES

[H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@H](C)[C@H](O1)\C=C\C

Targets

P08183ABCB1

Transporters

P08183ABCB1

What you can answer from here — as of June 12, 2020

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Concanamycin A, and which of those have an active Phase 3 trial?

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