Accession Number

Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis.

DrugDrug Description
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
SirolimusAn mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
CethromycinA ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia.
MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...
AzithromycinA macrolide antibiotic used to treat a variety of bacterial infections.
FidaxomicinA macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection.
Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
Soraphen ANot Available
RadicicolNot Available
Aplyronine ANot Available
Reidispongiolide ANot Available
Bafilomycin A1The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins...
Bafilomycin B1Not Available
SpinosadA pediculicide used topically to treat head lice.
SolithromycinInvestigated for the treatment of community-acquired pneumonia (CAP).
GamithromycinGamithromycin is an antibiotic used in cattle.
Milbemycin oximeNot Annotated
PentamycinNot Annotated
Concanamycin AConcanamycin A is an H+-ATPase (vacuolar) inhibitor.
ModithromycinModithromycin is under investigation in clinical trial NCT00270517 (Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia).
RoxithromycinAn antibiotic used to treat a variety of susceptible bacterial infections.
DirithromycinAn antibiotic used to treat a variety of respiratory, skin, and other infections.
TelithromycinAn ketolide used to treat community acquired pneumonia of mild to moderate severity.
CandicidinUsed in the topical treatment of vulvovaginal candidiasis.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
JosamycinA macrolide antibiotic used for the treatment of various susceptible bacterial infections.
Epothilone DInvestigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.
PatupiloneInvestigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.
6-Deoxyerythronolide BNot Available
KOS-1584Investigated for use/treatment in solid tumors.
SpiramycinA macrolide antimicrobial agent used in the treatment of various bacterial infections.
MitemcinalInvestigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS).
Brefeldin AA metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
KitasamycinKitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis.
CarbomycinCarbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The...
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
EprinomectinNot Annotated
SelamectinSelamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in...
EpofolateEpofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target...
SagopiloneSagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is...
MiocamycinMiocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to...
FlurithromycinNot Annotated
MidecamycinA macrolide antibiotic used to treat a variety of infections caused by susceptible bacteria.
Josamycin propionateNot Annotated
NafithromycinNafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP).
CarrimycinNot Available
Nanaomycin DNot Available
EribulinA microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma.
LasalocidLasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis.
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
Tulathromycin ATulathromycin is a macrolide antibiotic used to treat bovine respiratory disease in cattle and swine respiratory disease in pigs. It is marketed by Pfizer Inc. under the tradename Draxxin.
SalinomycinNot Annotated
SemduramicinNot Annotated
NigericinA polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
Granaticin BNot Annotated
Drugs & Drug Targets
IvermectinP-glycoprotein 1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinCanalicular multispecific organic anion transporter 1transporter
IvermectinATP-binding cassette sub-family G member 2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
IvermectinCytochrome P450 2D6enzyme
IvermectinCytochrome P450 2E1enzyme
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
TacrolimusCytochrome P450 3A4enzyme
TacrolimusCytochrome P450 3A5enzyme
TacrolimusP-glycoprotein 1transporter
TacrolimusATP-binding cassette sub-family A member 5transporter
TacrolimusSerum albumincarrier
TacrolimusAlpha-1-acid glycoprotein 1carrier
TacrolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
SirolimusSerum albumincarrier
SirolimusAlpha-1-acid glycoprotein 1carrier
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
IxabepiloneTubulin beta-3 chaintarget
IxabepiloneCytochrome P450 3A4enzyme
IxabepiloneP-glycoprotein 1transporter
TemsirolimusSerine/threonine-protein kinase mTORtarget
TemsirolimusCytochrome P450 3A4enzyme
TemsirolimusCytochrome P450 3A5enzyme
TemsirolimusCytochrome P450 3A7enzyme
TemsirolimusCytochrome P450 2D6enzyme
TemsirolimusP-glycoprotein 1transporter
Cethromycin23S ribosomal RNAtarget
CethromycinCytochrome P450 3A5enzyme
CethromycinCytochrome P450 3A4enzyme
CethromycinP-glycoprotein 1transporter
MoxidectinCYP2B proteinenzyme
MoxidectinGlutamate-gated chloride channeltarget
MoxidectinGABA-A gated chloride channeltarget
MoxidectinABC transporterstarget
Azithromycin23S ribosomal RNAtarget
AzithromycinP-glycoprotein 1transporter
AzithromycinCytochrome P450 3A4enzyme
AzithromycinProtein-arginine deiminase type-4target
AzithromycinCanalicular multispecific organic anion transporter 1transporter
FidaxomicinP-glycoprotein 1transporter
FidaxomicinRNA polymerase sigma factortarget
FidaxomicinCytochrome P450 3A4enzyme
Amphotericin BErgosteroltarget
Soraphen AAcetyl-CoA carboxylase 2target
RadicicolHeat shock protein HSP 90-betatarget
RadicicolDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget
Radicicol[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrialtarget
RadicicolVirulence sensor histidine kinase PhoQtarget
Aplyronine AActin, alpha skeletal muscletarget
Reidispongiolide AActin, alpha skeletal muscletarget
Bafilomycin A1V-type proton ATPase catalytic subunit Atarget
Bafilomycin B1V-type proton ATPase catalytic subunit Atarget
SolithromycinCytochrome P450 3A4enzyme
Concanamycin AP-glycoprotein 1target
Concanamycin AP-glycoprotein 1transporter
Roxithromycin50S ribosomal protein L10target
RoxithromycinP-glycoprotein 1target
RoxithromycinCytochrome P450 3A4enzyme
RoxithromycinCytochrome P450 2B6enzyme
Dirithromycin23S ribosomal RNAtarget
DirithromycinCytochrome P450 3A4enzyme
Telithromycin23S ribosomal RNAtarget
TelithromycinCytochrome P450 3A4enzyme
TelithromycinSolute carrier organic anion transporter family member 1B1transporter
TelithromycinSolute carrier organic anion transporter family member 1B3transporter
CandicidinCytochrome P450 3A4enzyme
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinP-glycoprotein 1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinPotassium voltage-gated channel subfamily H member 2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
Josamycin50S ribosomal protein L4target
Epothilone DTubulin alpha 3C/D chaintarget
Epothilone DTubulin beta chaintarget
Epothilone DTubulin beta-1 chaintarget
Epothilone DTubulin beta-4B chaintarget
Epothilone DTubulin beta-4A chaintarget
Epothilone DTubulin alpha-4A chaintarget
Epothilone DTubulin beta-3 chaintarget
Epothilone DTubulin alpha-1C chaintarget
Epothilone DTubulin alpha-8 chaintarget
Epothilone DTubulin alpha-1B chaintarget
Epothilone DTubulin alpha-1A chaintarget
Epothilone DCytochrome P450 3A4enzyme
PatupiloneTubulin alpha 3C/D chaintarget
PatupiloneTubulin beta chaintarget
PatupiloneTubulin beta-1 chaintarget
PatupiloneTubulin beta-4B chaintarget
PatupiloneTubulin beta-4A chaintarget
PatupiloneTubulin alpha-4A chaintarget
PatupiloneTubulin beta-3 chaintarget
PatupiloneTubulin alpha-1C chaintarget
PatupiloneTubulin alpha-8 chaintarget
PatupiloneTubulin alpha-1B chaintarget
PatupiloneTubulin alpha-1A chaintarget
PatupiloneCytochrome P450 3A4enzyme
6-Deoxyerythronolide B6-deoxyerythronolide B hydroxylasetarget
6-Deoxyerythronolide BCytochrome P450 3A4enzyme
KOS-1584Cytochrome P450 3A4enzyme
Spiramycin50S ribosomal protein L3target
MitemcinalMotilin receptortarget
MitemcinalCytochrome P450 3A4enzyme
Brefeldin ACytohesin-2target
Brefeldin AADP-ribosylation factor 1target
Brefeldin ACytochrome P450 3A4enzyme
KitasamycinCytochrome P450 3A4enzyme
CarbomycinCytochrome P450 3A4enzyme
DoramectinCytochrome P450 3A4enzyme
EprinomectinCytochrome P450 3A4enzyme
SelamectinCytochrome P450 3A4enzyme
EpofolateCytochrome P450 3A4enzyme
SagopiloneCytochrome P450 3A4enzyme
MiocamycinCytochrome P450 3A4enzyme
FlurithromycinCytochrome P450 3A4enzyme
MidecamycinCytochrome P450 3A4enzyme
Nanaomycin DActVA 6 proteintarget
EribulinApoptosis regulator Bcl-2target
EribulinTubulin beta-1 chaintarget
MonensinP-glycoprotein 1transporter
SalinomycinP-glycoprotein 1transporter