Polyketides

DBCAT000497Pharmacologic class

Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis. A DrugBank category of 66 drugs. 19 of them are approved.

Also known as: Ketides
Drugs: 6-Deoxyerythronolide B
Amphotericin B
Aplyronine A
Azithromycin
Bafilomycin A1
Bafilomycin B1
Brefeldin A
Calcimycin
Candicidin
Carbomycin
Carrimycin
Cethromycin
Clarithromycin
Concanamycin A
Dirithromycin
Doramectin
Epofolate
Epothilone D
Eprinomectin
Eribulin
Everolimus
Fidaxomicin
Flurithromycin
Gamithromycin
Granaticin B
and 41 more with a free account

What you can answer from here — as of August 24, 2016

66DrugsEach linked to its full drug card

59Drug targetsEvery drug–target pair in the class, with bond type

5,191Marketed productsAcross the regions we cover, with dosage forms and routes

11Routes of administrationHow the drugs in this class are given

Which targets do Polyketides share, and which companies have late-stage candidates in this class?

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