Mucocutaneous Lymph Node Syndrome (DBCOND0000706)

Identifiers

Synonyms

Kawasaki's disease / Kawasaki Disease / Kawasaki Syndrome / Mucocutaneous lymph node syndrome / Mucocutaneous lymph node syndrome [Kawasaki] / Acute febrile mucocutaneous lymph node syndrome (MCLS) / Acute febrile mucocutaneous lymph node syndrome (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Human immunoglobulin G	A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders.	Low affinity immunoglobulin gamma Fc region receptor III-Btarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget High affinity immunoglobulin gamma Fc receptor Itarget Low affinity immunoglobulin gamma Fc region receptor II-atarget Low affinity immunoglobulin gamma Fc region receptor II-btarget Low affinity immunoglobulin gamma Fc region receptor II-ctarget Putative high affinity immunoglobulin gamma Fc receptor IBtarget Complement C3target Complement C4-Atarget Complement C4-Btarget Complement C5target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04509219	Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease	Methylprednisolone	treatment	1	unknown_status
NCT00000520	Prevention of Coronary Aneurysms in Kawasaki Syndrome	Acetylsalicylic acid Human immunoglobulin G	prevention	2	completed
NCT03880929	Epidemiologic Features of Kawasaki Disease in Shanghai From 2013 Through 2017	No drug interventions	Not Available	Not Available	completed
NCT00841789	A Randomized, Double Blind, Placebo Controlled Study of Etanercept in Children With Kawasaki Disease	Etanercept	treatment	2	completed
NCT03065244	KIDCARE (Kawasaki Disease Comparative Effectiveness Trial)	Human immunoglobulin G Infliximab	treatment	3	completed
NCT06641817	The Value of Cardiovascular Imaging in Kawasaki Disease	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT06641843	Magnetic Resonance Myocardial Stress Perfusion in Pediatric Patients with Cardiovascular Disease	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT04078568	Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease	Acetylsalicylic acid Fluocinolone acetonide Human immunoglobulin G Prednisolone	treatment	3	recruiting
NCT01917721	Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease	Doxycycline Infliximab	treatment	2	unknown_status
NCT01431105	Pharmacokinetics (PK)/Safety Study of Atorvastatin in Children With Kawasaki Disease and Coronary Artery Abnormalities	Atorvastatin	treatment	1 / 2	completed
NCT06305611	European and North Indian Cohort of KaWasaki dIsease	No drug interventions	Not Available	Not Available	recruiting
NCT02771288	Safety and Vascular Remodelling After BVS Implantation for Stenotic or Occluded Lesions in Children and Young Adults With KD.	No drug interventions	treatment	Not Available	unknown_status
NCT00271570	Infliximab (Remicade) for Patients With Acute Kawasaki Disease	Human immunoglobulin G Infliximab	treatment	1	completed
NCT04535518	Efficacy of Immunoglobulin Plus Infliximab for the Early Regression of Coronary Artery Lesion in Kawasaki Disease	Acetylsalicylic acid Human immunoglobulin G Infliximab	treatment	3	withdrawn
NCT02439996	Different Doses of IVIG for Kawasaki Disease	Acetylsalicylic acid	treatment	3	completed
NCT02390596	Anakinra and Kawasaki Disease	Anakinra	treatment	2	completed
NCT00760435	Infliximab Plus Intravenous Immunoglobulin for the Primary Treatment of Kawasaki Disease	Infliximab	treatment	3	completed
NCT05911386	Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01524939	Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease	No drug interventions	treatment	4	completed
NCT04777422	Defibrotide in Children With High Risk Kawasaki Disease	Defibrotide	treatment	2	active_not_recruiting
NCT00861848	Real Time Myocardial Contrast Echocardiography and Dobutamine Stress Perfusion Magnetic Resonance Imaging	No drug interventions	Not Available	Not Available	completed
NCT02853266	Measurement of Antibodies in Adults With a History of Kawasaki Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT02298062	Infliximab for Kawasaki Disease Patients Resistant to IVIG : a Multicentre, Prospective, Randomised Trial	Infliximab	treatment	3	completed
NCT02359643	Multi-center Prospective Randomized Control Trail of High Dose Aspirin in Acute Stage of Kawasaki Disease	Acetylsalicylic acid	treatment	Not Available	unknown_status
NCT06309303	Kawasaki Disease During the COVID-19 Epidemic	No drug interventions	Not Available	Not Available	completed
NCT04656184	A Trial Comparing the Efficacy and Safety of Anakinra Versus Intravenous Immunoglobulin (IVIG) Retreatment, in Patients With Kawasaki Disease Who Failed to Respond to Initial Standard IVIG Treatment	Anakinra Human immunoglobulin G	treatment	3	recruiting
NCT05643651	Rivaroxaban for Children With Giant Coronary Artery Aneurysms After Kawasaki Disease	Acetylsalicylic acid Clopidogrel Phylloquinone Rivaroxaban Warfarin	prevention	4	not_yet_recruiting
NCT02179853	Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease	Anakinra	treatment	1 / 2	completed
NCT04747847	Pilot Study of Atorvastatin and Anakinra in Children With Coronary Artery Abnormalities Secondary to Kawasaki Disease	Anakinra Atorvastatin	treatment	0	active_not_recruiting
NCT00162045	A Trial to Determine Radiation Exposure to Organs and Assess the Safety of CARDIOLITE® in Pediatric Subjects	Technetium Tc-99m sestamibi	diagnostic	1 / 2	completed
NCT03200561	A Trial to Evaluate the Efficacy of Immunoglobulin Plus Steroid for Prevention of Coronary Artery Abnormalities in Taiwanese Refractory Kawasaki Disease (RAST Study)	Prednisolone	treatment	3	unknown_status
NCT00162032	A Study to Evaluate the Use and Safety of CARDIOLITE® in Pediatric Patients With Kawasaki Disease	Technetium Tc-99m sestamibi Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate	diagnostic	3	completed
NCT01440075	Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease	No drug interventions	health_services_research	Not Available	completed
NCT02176070	Reproductive Health in Men and Women With Vasculitis	No drug interventions	Not Available	Not Available	completed
NCT02114099	Trial of Atorvastatin on the Persistent Coronary Aneurysm in Children With Kawasaki Disease	Atorvastatin	treatment	2	unknown_status
NCT02317913	Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012	No drug interventions	Not Available	Not Available	completed
NCT02951234	A Multi-center, Randomized to Compare the Efficacy of IVIG Alone and IVIG Plus High-dose Aspirin in Kawasaki Disease	No drug interventions	treatment	Not Available	unknown_status
NCT00154596	Etiology Study of Kawasaki Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT02980263	Study of Efficacy and Safety of Canakinumab in Pediatric Patients With Kawasaki Disease	Canakinumab	treatment	2	withdrawn
NCT03861130	Genetic Determinants of Kawasaki Disease	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03902262	Acute Abdomen in Kawasaki Disease	No drug interventions	Not Available	Not Available	completed
NCT05091229	A Blood Test to Diagnose Kawasaki Disease	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04003844	Study of Combined Therapy IVIG-SN 10% and Acetylsalicylic Acid in Kawasaki Disease	Acetylsalicylic acid	treatment	4	completed
NCT00305201	Cardiovascular Risk Markers and Response to Statins After Kawasaki Disease	Pravastatin	treatment	2	withdrawn
NCT05347901	Clinical Precise Diagnosis and Treatment in the Kawasaki Disease	No drug interventions	Not Available	Not Available	recruiting
NCT04278404	Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)	Abatacept Acetylsalicylic acid Aminocaproic acid Amiodarone Amphetamine Anakinra Azithromycin Bosentan Budesonide Canakinumab Cefdinir Cefepime Ceftazidime Clindamycin Clobazam Colchicine Dexamethasone Dexmedetomidine Fosfomycin Furosemide Gabapentin Guanfacine Hydrocortisone Infliximab Labetalol Lopinavir Meropenem Metformin Milrinone Nalbuphine Nicardipine Nifedipine Oseltamivir Oxycodone Remdesivir Ribavirin Risperidone Ritonavir Ruxolitinib Sarilumab Sertraline Sevelamer Spironolactone Terbutaline Tocilizumab Tranexamic acid Voriconazole Zolpidem	Not Available	Not Available	recruiting
NCT01793168	Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford	No drug interventions	Not Available	Not Available	recruiting
NCT04538495	Characterization of Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Relationship to Kawasaki Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT03915795	Statins Study in Kawasaki Disease Children With Coronary Artery Abnormalities	No drug interventions	Not Available	Not Available	completed
NCT03750123	Cardiovascular Status of Children 5 Years After Kawasaki Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT00157079	Safety and Efficacy Study of a 10% Intravenous Immune Globulin Solution in Subjects With Primary Immunodeficiency Disorders	Human immunoglobulin G	treatment	3	completed