Oxidronic acid

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Oxidronic acid
DrugBank Accession Number
DB14159
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 192.0
Monoisotopic: 191.958876529
Chemical Formula
CH6O7P2
Synonyms
  • (Hydroxymethylene)diphosphonic acid
  • Acido oxidronico
  • Acidum oxidronicum
  • HMD-P
  • HMDP
  • Hydroxymethanediphosphonic acid
  • Oxidronate
  • Oxidronic acid

Pharmacology

Indication

Oxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients.1

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Diagnostic agentOsteogenesis imperfecta (oi)•••••••••••••••••• •••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Oxidronate disodiumH852YK87WP14255-61-9VKKZUCSEWNITRU-UHFFFAOYSA-L
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Technescan HDPInjection, powder, lyophilized, for solution3.15 mg/1IntravenousCurium US LLC2015-10-13Not applicableUS flag
TechneScan HDPInjection, powder, lyophilized, for solution3.15 mg/1IntravenousMallinckrodt2007-02-272017-07-01US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
71MR4V32TI
CAS number
15468-10-7
InChI Key
HJZKOAYDRQLPME-UHFFFAOYSA-N
InChI
InChI=1S/CH6O7P2/c2-1(9(3,4)5)10(6,7)8/h1-2H,(H2,3,4,5)(H2,6,7,8)
IUPAC Name
[hydroxy(phosphono)methyl]phosphonic acid
SMILES
OC(P(O)(O)=O)P(O)(O)=O

References

General References
  1. FDA Approved Drug Products: Technescan HDP (Kit for the Preparation of Technetium Tc 99m Oxidronate), for intravenous use [Link]
ChemSpider
25412
RxNav
1546448
ChEBI
134844
ChEMBL
CHEMBL1615775
ZINC
ZINC000024740492

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous3 mg
Injection, powder, lyophilized, for solutionIntravenous
Injection, powder, lyophilized, for solutionIntravenous3.15 mg/1
Injection, powder, for solutionIntravenous3 mg
Injection, powder, for solutionIntravenous3.15 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility13.5 mg/mLALOGPS
logP-1.1ALOGPS
logP-2Chemaxon
logS-1.2ALOGPS
pKa (Strongest Acidic)0.75Chemaxon
pKa (Strongest Basic)-5Chemaxon
Physiological Charge-3Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count5Chemaxon
Polar Surface Area135.29 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity29.72 m3·mol-1Chemaxon
Polarizability12.21 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00di-0900000000-a29349be9077d76ae0a3
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-002f-8900000000-64f211129525f5ad2f34
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-0900000000-7f88a2dd565b0ebfc5cf
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00dl-0900000000-4057fe2cddb4eb05a22b
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01q9-9000000000-bb46c92d409e5ad8d53b
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-03fr-9000000000-fc7d0b7166bbe341d34c
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-132.9185894
predicted
DarkChem Lite v0.1.0
[M+H]+133.8500894
predicted
DarkChem Lite v0.1.0
[M+Na]+133.0317894
predicted
DarkChem Lite v0.1.0

Drug created at June 29, 2018 15:25 / Updated at February 21, 2021 18:54