Oxidronic acid

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Oxidronic acid
DrugBank Accession Number
DB14159
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 192.0
Monoisotopic: 191.958876529
Chemical Formula
CH6O7P2
Synonyms
  • (Hydroxymethylene)diphosphonic acid
  • Acido oxidronico
  • Acidum oxidronicum
  • HMD-P
  • HMDP
  • Hydroxymethanediphosphonic acid
  • Oxidronate
  • Oxidronic acid

Pharmacology

Indication

Oxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients.1

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Product Ingredients
IngredientUNIICASInChI Key
Oxidronate disodiumH852YK87WP14255-61-9VKKZUCSEWNITRU-UHFFFAOYSA-L
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
TechneScan HDPInjection, powder, lyophilized, for solution3.15 mg/1IntravenousMallinckrodt2007-02-272017-07-01US flag
Technescan HDPInjection, powder, lyophilized, for solution3.15 mg/1IntravenousCurium US LLC2015-10-13Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
71MR4V32TI
CAS number
15468-10-7
InChI Key
HJZKOAYDRQLPME-UHFFFAOYSA-N
InChI
InChI=1S/CH6O7P2/c2-1(9(3,4)5)10(6,7)8/h1-2H,(H2,3,4,5)(H2,6,7,8)
IUPAC Name
[hydroxy(phosphono)methyl]phosphonic acid
SMILES
OC(P(O)(O)=O)P(O)(O)=O

References

General References
  1. FDA Approved Drug Products: Technescan HDP (Kit for the Preparation of Technetium Tc 99m Oxidronate), for intravenous use [Link]
ChemSpider
25412
RxNav
1546448
ChEBI
134844
ChEMBL
CHEMBL1615775
ZINC
ZINC000024740492

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous3 mg
Injection, powder, lyophilized, for solutionIntravenous
Injection, powder, lyophilized, for solutionIntravenous3.15 mg/1
Injection, powder, for solutionIntravenous3 mg
Injection, powder, for solutionIntravenous3.15 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility13.5 mg/mLALOGPS
logP-1.1ALOGPS
logP-2ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)0.75ChemAxon
pKa (Strongest Basic)-5ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area135.29 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity29.72 m3·mol-1ChemAxon
Polarizability12.21 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 29, 2018 15:25 / Updated on February 21, 2021 18:54