Organophosphorus Compounds

Organophosphorus Compounds
Accession Number

Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.

DrugDrug Description
Pamidronic acidA bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
Tenofovir disoproxilA nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection.
CidofovirAn antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS.
Zoledronic acidA bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
FoscarnetAn antiviral used to treat CMV, HIV, and HSV infections.
CyclophosphamideA nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
Alendronic acidA bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.
IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
IbandronateA bisphosphonate used to treat osteoporosis in postmenopausal women.
Adefovir dipivoxilA nucleotide analog used to treat chronic hepatitis B.
Clodronic acidA bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis.
MalathionA parasympathomimetic organophosphate used to treat head lice.
FosfomycinA broad spectrum antibiotic used to treat uncomplicated urinary tract infections.
Risedronic acidA bisphosphonate used to treat osteoporosis and Paget's disease.
EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
Etidronic acidA bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
Tiludronic acidA bisphosphonate used for the treatment of Paget's disease of bone.
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
FosamprenavirAn antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection.
Diethyl 4-MethylbenzylphosphonateNot Available
2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidNot Available
Leucine Phosphonic AcidNot Available
Adenosine Phosphonoacetic AcidNot Available
Phosphonoacetic AcidA simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem]
Methylphosphinic AcidNot Available
FosmidomycinNot Available
PhenylphosphateNot Available
Triethyl phosphateNot Available
Sparfosic acidSparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen...
ThiotepaAn alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas.
Farnesyl thiopyrophosphateNot Available
MB07811Investigated for use/treatment in hyperlipidemia.
AZD 3355Investigated for use/treatment in gastroesophageal reflux disease (GERD).
Managlinat dialanetilInvestigated for use/treatment in diabetes mellitus type 2.
PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
EvofosfamideInvestigated for use/treatment in solid tumors.
FosdevirineInvestigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections.
GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
Incadronic acidIncadronate has been investigated in the treatment of myeloma,[A14426,A14431] leukemia, and other cancers. It has also been investigated in patients with hypercalcemia of malignancy.
Minodronic acidInvestigated for use/treatment in multiple myeloma, breast cancer, osteoporosis, and lung cancer.
TriclofosNot Annotated
Decyl(dimethyl)phosphine oxideNot Available
Farnesyl diphosphateNot Available
Geranylgeranyl diphosphateNot Available
Tedizolid phosphateAn oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections.
Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
Technetium Tc-99m etidronateNot Annotated
ButonateNot Annotated
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
CythioateCythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas.
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
FamphurNot Annotated
FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
RonnelNot Annotated
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
SulfotepNot Annotated
Neridronic AcidA bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.
BarasertibBarasertib has been used in trials studying the treatment of Tumors, Lymphoma, Solid Tumors, Solid Tumours, and Myeloid Leukemia, among others.
ZytronZytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic). DMPA has been investigated for the...
FostemsavirAn antiretroviral HIV-1 attachment inhibitor targeted against the gp120 subunit within the HIV-1 gp160 envelope glycoprotein.
LesogaberanLesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others.
MafosfamideMafosfamide has been used in trials studying the treatment of Lymphoma, Leukemia, Meningeal Neoplasm, and Brain and Central Nervous System Tumors.
BrincidofovirBrincidofovir is under investigation for the prevention of Outcomes, Survival Rates, and Cytomegalovirus Disease. Brincidofovir has been investigated for the prevention and treatment of CMV, Adenovirus, BK Virus (BKV), Adenoviruses...
TemefosDiphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
ApomineApomine has been used in trials studying the treatment of Osteoporosis and Unspecified Adult Solid Tumor, Protocol Specific.
PerzinfotelPerzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.
FanapanelFanapanel has been investigated for the treatment of Visual Acuity.
PerfosfamidePerfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.
GS-9256GS-9256 has been used in trials studying the treatment of HCV Infection and Chronic Hepatitis C Infection.
TrofosfamideTrofosfamide has been used in trials studying the treatment of Ependymomas, Medulloblastomas, Sarcoma, Soft Tissue, Supratentorial PNETs, and Recurrent Brain Tumors.
ParaoxonNot Annotated
AdefovirNot Annotated
TenofovirA nucleotide analog indicated in the treatment of HIV infections.
Oxidronic acidOxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients.
FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
AB192Investigated for use/treatment in diabetes mellitus type 2.
Methoxy arachidonyl fluorophosphonateMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid...
Tenofovir exalidexTenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).
MethamidophosMethamidophos is under investigation in clinical trial NCT03223753 (Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia in First Remission).
SelatogrelSelatogrel is under investigation in clinical trial NCT03814200 (A Study to Investigate the Effect of Rifampicin on the Uptake and Breakdown of ACT-246475 in Healthy Subjects).
Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is...
FosdagrocoratFosdagrocorat has been used in trials studying the treatment and basic science of Rheumatoid Arthritis.
Ethyl dihydrogen phosphateNot Available
Besifovir dipivoxilInvestigated for use/treatment in hepatitis (viral, B).
BesifovirNot Annotated
Drugs & Drug Targets
Pamidronic acidFarnesyl pyrophosphate synthasetarget
Pamidronic acidHydroxylapatitetarget
Pamidronic acidGeranylgeranyl pyrophosphate synthasetarget
Pamidronic acidCaspase-3target
Pamidronic acidCaspase-9target
Tenofovir disoproxilReverse transcriptase/RNaseHtarget
Tenofovir disoproxilSolute carrier family 22 member 6transporter
Tenofovir disoproxilSolute carrier family 22 member 8transporter
Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
Tenofovir disoproxilP-glycoprotein 1transporter
Tenofovir disoproxilNucleoside diphosphokinaseenzyme
Tenofovir disoproxilCreatine Kinasesenzyme
Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
CidofovirDNA polymerase catalytic subunittarget
CidofovirSolute carrier family 22 member 6transporter
CidofovirThymidine phosphorylaseenzyme
Zoledronic acidFarnesyl pyrophosphate synthasetarget
Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
Zoledronic acidHydroxylapatitetarget
Zoledronic acidMultidrug resistance-associated protein 1transporter
FosinoprilAngiotensin-converting enzymetarget
FosinoprilSolute carrier family 15 member 1transporter
FosinoprilSolute carrier family 15 member 2transporter
FoscarnetDNA polymerase catalytic subunittarget
FoscarnetDNA polymerase catalytic subunittarget
FoscarnetSolute carrier family 22 member 6transporter
FoscarnetMonocarboxylate transporter 1transporter
CyclophosphamideCytochrome P450 2B6enzyme
CyclophosphamideCytochrome P450 2C9enzyme
CyclophosphamideCytochrome P450 3A4enzyme
CyclophosphamideCytochrome P450 2C19enzyme
CyclophosphamideCytochrome P450 2A6enzyme
CyclophosphamideCytochrome P450 2C18enzyme
CyclophosphamideCytochrome P450 2C8enzyme
CyclophosphamideCytochrome P450 3A5enzyme
CyclophosphamideNuclear receptor subfamily 1 group I member 2target
Alendronic acidFarnesyl pyrophosphate synthasetarget
Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Alendronic acidV-type proton ATPase catalytic subunit Atarget
Alendronic acidHydroxylapatitetarget
IsoflurophateSerum albumincarrier
IbandronateFarnesyl pyrophosphate synthasetarget
IbandronateGeranylgeranyl pyrophosphate synthasetarget
Adefovir dipivoxilDNA polymerase/reverse transcriptasetarget
Adefovir dipivoxilSolute carrier family 22 member 6transporter
Adefovir dipivoxilMultidrug resistance-associated protein 4transporter
Adefovir dipivoxilMultidrug resistance-associated protein 5transporter
Adefovir dipivoxilSolute carrier family 22 member 3transporter
Adefovir dipivoxilAdenylate kinase 2, mitochondrialenzyme
Adefovir dipivoxilAdenylate kinase 4, mitochondrialenzyme
Adefovir dipivoxilNucleoside diphosphate kinase Aenzyme
Adefovir dipivoxilNucleoside diphosphate kinase Benzyme
Clodronic acidADP/ATP translocase 2target
Clodronic acidADP/ATP translocase 1target
Clodronic acidADP/ATP translocase 3target
Clodronic acidHydroxylapatitetarget
Clodronic acidProstaglandin G/H synthase 2enzyme
MalathionCytochrome P450 1A2enzyme
MalathionCytochrome P450 2B6enzyme
FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
Risedronic acidFarnesyl pyrophosphate synthasetarget
Risedronic acidHydroxylapatitetarget
Risedronic acidProstaglandin G/H synthase 2enzyme
EchothiophateSerum albumincarrier
Etidronic acidHydroxylapatitetarget
Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
Etidronic acidV-type proton ATPase catalytic subunit Atarget
Etidronic acidADP/ATP translocase 1target
Etidronic acidADP/ATP translocase 2target
Etidronic acidADP/ATP translocase 3target
Tiludronic acidTyrosine-protein phosphatase non-receptor type 12target
Tiludronic acidV-ATPase Subunitstarget
Tiludronic acidHydroxylapatitetarget
Tiludronic acidAdenosine triphosphate (ATP)target
Tiludronic acidSerum albumincarrier
Tiludronic acidTyrosine-protein phosphatase non-receptor type 6target
Tiludronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
AmifostineAlkaline phosphatase, placental-liketarget
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
IfosfamideCytochrome P450 2B6enzyme
IfosfamideCytochrome P450 3A4enzyme
IfosfamideCytochrome P450 3A5enzyme
IfosfamideCytochrome P450 2C9enzyme
IfosfamideCytochrome P450 2C8enzyme
IfosfamideCytochrome P450 2A6enzyme
IfosfamideCytochrome P450 2C19enzyme
IfosfamideCytochrome P450 2C18enzyme
IfosfamideProstaglandin G/H synthase 1enzyme
IfosfamideNuclear receptor subfamily 1 group I member 2target
FosamprenavirHuman immunodeficiency virus type 1 proteasetarget
FosamprenavirCytochrome P450 3A4enzyme
Diethyl 4-MethylbenzylphosphonateParathion hydrolasetarget
Diethyl 4-MethylbenzylphosphonateParathion hydrolasetarget
2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidGlutamate receptor 2target
Leucine Phosphonic AcidBacterial leucyl aminopeptidasetarget
Leucine Phosphonic AcidCytosol aminopeptidasetarget
Adenosine Phosphonoacetic AcidNucleoside diphosphate kinase Atarget
Phosphonoacetic AcidAlkaline phosphatasetarget
Methylphosphinic AcidEsterasetarget
Methylphosphinic AcidCholinesterasetarget
Methylphosphinic AcidAcetylcholinesterasetarget
Methylphosphinic AcidCholinesteraseenzyme
Fosmidomycin1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
PhenylphosphateProto-oncogene tyrosine-protein kinase Srctarget
Triethyl phosphateParathion hydrolasetarget
Triethyl phosphateParathion hydrolasetarget
Triethyl phosphateCellular tumor antigen p53target
Sparfosic acidAspartate carbamoyltransferase catalytic chaintarget
Sparfosic acidCAD proteintarget
ThiotepaCytochrome P450 2B6enzyme
ThiotepaCytochrome P450 3A4enzyme
Farnesyl thiopyrophosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
Farnesyl thiopyrophosphateGeranylgeranyl pyrophosphate synthasetarget
Farnesyl thiopyrophosphateMevalonate kinasetarget
Farnesyl thiopyrophosphateDehydrosqualene synthasetarget
MB07811Thyroid hormone receptor betatarget
AZD 3355Cellular tumor antigen p53target
Managlinat dialanetilFructose-1,6-bisphosphatase 1target
PalifosfamideDNA (cytosine-5)-methyltransferase 1target
Incadronic acidFarnesyl pyrophosphate synthasetarget
Incadronic acidCaspase-3target
Incadronic acidCaspase-4target
Incadronic acidCaspase-7target
Minodronic acidFarnesyl pyrophosphate synthasetarget
Minodronic acidGeranylgeranyl pyrophosphate synthasetarget
Decyl(dimethyl)phosphine oxideAmine oxidase [flavin-containing] Atarget
Farnesyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Farnesyl diphosphateProtein farnesyltransferase subunit betatarget
Farnesyl diphosphateGTPase KRastarget
Farnesyl diphosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
Farnesyl diphosphateFarnesyl pyrophosphate synthasetarget
Farnesyl diphosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
Farnesyl diphosphateLantibiotic nisin-Ztarget
Farnesyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
Farnesyl diphosphate(2Z,6E)-farnesyl diphosphate synthasetarget
Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
Geranylgeranyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-1 subunit betatarget
Geranylgeranyl diphosphateProtein farnesyltransferase subunit betatarget
Geranylgeranyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
Geranylgeranyl diphosphateFarnesyl pyrophosphate synthasetarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDProtein farnesyltransferase subunit betatarget
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Tedizolid phosphate23S ribosomal RNAtarget
Tedizolid phosphateAmine oxidase [flavin-containing] Aenzyme
Tedizolid phosphateAmine oxidase [flavin-containing] Benzyme
DichlorvosSerum albumincarrier
FostemsavirCytochrome P450 3A4enzyme
FostemsavirUDP-glucuronosyltransferases (UGTs)enzyme
FostemsavirP-glycoprotein 1transporter
FostemsavirATP-binding cassette sub-family G member 2transporter
FostemsavirSolute carrier organic anion transporter family member 1B1transporter
FostemsavirSolute carrier organic anion transporter family member 1B3transporter
FostemsavirSerum albumincarrier
FostemsavirEnvelope glycoprotein gp160target
AdefovirDNA polymerase/reverse transcriptasetarget
TenofovirP-glycoprotein 1transporter
TenofovirSolute carrier family 22 member 6transporter
TenofovirSolute carrier family 22 member 8transporter
TenofovirMultidrug resistance-associated protein 4transporter
TenofovirNucleoside diphosphate kinase Aenzyme
TenofovirNucleoside diphosphate kinase Benzyme
TenofovirAdenylate kinase isoenzyme 1enzyme
TenofovirAdenylate kinase 2, mitochondrialenzyme
TenofovirReverse transcriptase/RNaseHtarget
TenofovirReverse transcriptasetarget
TenofovirDNA polymerasetarget
TenofovirSerum albumincarrier
Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
Technetium Tc-99m oxidronateSerum albumincarrier
Ethyl dihydrogen phosphateParathion hydrolasetarget
Ethyl dihydrogen phosphateCholinesterasetarget
Ethyl dihydrogen phosphateCholinesteraseenzyme
Besifovir dipivoxilDNA polymerasetarget