- Organophosphorus Compounds
- Accession Number
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Drug Drug Description Pamidronic acid A bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions. Tenofovir disoproxil A nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection. Zoledronic acid A bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. Alendronic acid A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis. Ibandronate A bisphosphonate used to treat osteoporosis in postmenopausal women. Clodronic acid A bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis. Fosfomycin A broad spectrum antibiotic used to treat uncomplicated urinary tract infections. Risedronic acid A bisphosphonate used to treat osteoporosis and Paget's disease. Etidronic acid A bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis. Tiludronic acid A bisphosphonate used for the treatment of Paget's disease of bone. Incadronic acid Incadronate has been investigated in the treatment of myeloma,[A14426,A14431] leukemia, and other cancers. It has also been investigated in patients with hypercalcemia of malignancy. Tedizolid phosphate An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections. Fostemsavir An antiretroviral HIV-1 attachment inhibitor targeted against the gp120 subunit within the HIV-1 gp160 envelope glycoprotein. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Tenofovir A nucleotide analog indicated in the treatment of HIV infections. Adefovir dipivoxil A nucleotide analog used to treat chronic hepatitis B. Diethyl 4-Methylbenzylphosphonate Not Available 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Not Available Leucine Phosphonic Acid Not Available Methoxy arachidonyl fluorophosphonate Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid... Phenylphosphate Not Available Triethyl phosphate Not Available Ethyl dihydrogen phosphate Not Available Besifovir dipivoxil Investigated for use/treatment in hepatitis (viral, B). Amonafide Investigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer. MB07811 Investigated for use/treatment in hyperlipidemia. Managlinat dialanetil Investigated for use/treatment in diabetes mellitus type 2. AB192 Investigated for use/treatment in diabetes mellitus type 2. Triclofos Not Annotated ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID Not Available Butonate Not Annotated Cythioate Cythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas. Famphur Not Annotated Ronnel Not Annotated Sulfotep Not Annotated Barasertib Barasertib has been used in trials studying the treatment of Tumors, Lymphoma, Solid Tumors, Solid Tumours, and Myeloid Leukemia, among others. Zytron Zytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic). DMPA has been investigated for the... Fosdagrocorat Fosdagrocorat has been used in trials studying the treatment and basic science of Rheumatoid Arthritis. Temefos Diphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria. Perzinfotel Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful. Fanapanel Fanapanel has been investigated for the treatment of Visual Acuity. Adefovir Not Annotated Tenofovir exalidex Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers). Methamidophos Methamidophos is under investigation in clinical trial NCT03223753 (Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia in First Remission). VK-2809 VK-2809 is under investigation in clinical trial NCT02927184 (Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease). Selatogrel Selatogrel is under investigation in clinical trial NCT03814200 (A Study to Investigate the Effect of Rifampicin on the Uptake and Breakdown of ACT-246475 in Healthy Subjects). Besifovir Not Annotated Cidofovir An antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. Fosinopril An ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics. Foscarnet An antiviral used to treat CMV, HIV, and HSV infections. Cyclophosphamide A nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Isoflurophate For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. Malathion A parasympathomimetic organophosphate used to treat head lice. Echothiophate An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. Amifostine A cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer. Ifosfamide An alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Adenosine Phosphonoacetic Acid Not Available Phosphonoacetic Acid A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem] Methylphosphinic Acid Not Available Fosmidomycin Not Available Sparfosic acid Sparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen... Thiotepa An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. Farnesyl thiopyrophosphate Not Available AZD 3355 Investigated for use/treatment in gastroesophageal reflux disease (GERD). Palifosfamide Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma. Evofosfamide Investigated for use/treatment in solid tumors. Fosdevirine Investigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections. Glufosfamide Investigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma. Minodronic acid Investigated for use/treatment in multiple myeloma, breast cancer, osteoporosis, and lung cancer. Decyl(dimethyl)phosphine oxide Not Available Farnesyl diphosphate Not Available Geranylgeranyl diphosphate Not Available Technetium Tc-99m medronate A diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis. Technetium Tc-99m oxidronate Technetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is... Tenofovir alafenamide A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease. Technetium Tc-99m etidronate Not Annotated Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Dichlorvos Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products... Fenthion Fenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is... Phosmet Phosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,... Metrifonate Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate. Neridronic Acid A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis. Lesogaberan Lesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others. Mafosfamide Mafosfamide has been used in trials studying the treatment of Lymphoma, Leukemia, Meningeal Neoplasm, and Brain and Central Nervous System Tumors. Apomine Apomine has been used in trials studying the treatment of Osteoporosis and Unspecified Adult Solid Tumor, Protocol Specific. Perfosfamide Perfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm. GS-9256 GS-9256 has been used in trials studying the treatment of HCV Infection and Chronic Hepatitis C Infection. Trofosfamide Trofosfamide has been used in trials studying the treatment of Ependymomas, Medulloblastomas, Sarcoma, Soft Tissue, Supratentorial PNETs, and Recurrent Brain Tumors. Paraoxon Not Annotated Oxidronic acid Oxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients. Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). AT-527 Not Available Minnelide free acid Not Annotated Minnelide Not Annotated
- Drugs & Drug Targets