Organophosphonates

Name
Organophosphonates
Accession Number
DBCAT000698
Description

Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.

Drugs
DrugDrug Description
Pamidronic acidA bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
Zoledronic acidA bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
Alendronic acidA bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.
IbandronateA bisphosphonate used to treat osteoporosis in postmenopausal women.
Clodronic acidA bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis.
FosfomycinA broad spectrum antibiotic used to treat uncomplicated urinary tract infections.
Risedronic acidA bisphosphonate used to treat osteoporosis and Paget's disease.
Etidronic acidA bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
Tiludronic acidA bisphosphonate used for the treatment of Paget's disease of bone.
Phosphonoacetic AcidA simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem]
Incadronic acidIncadronate has been investigated in the treatment of myeloma,[A14426,A14431] leukemia, and other cancers. It has also been investigated in patients with hypercalcemia of malignancy.
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
TenofovirA nucleotide analog indicated in the treatment of HIV infections.
CidofovirAn antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS.
Drugs & Drug Targets
DrugTargetType
Pamidronic acidFarnesyl pyrophosphate synthasetarget
Pamidronic acidHydroxylapatitetarget
Pamidronic acidGeranylgeranyl pyrophosphate synthasetarget
Pamidronic acidCaspase-3target
Pamidronic acidCaspase-9target
Zoledronic acidFarnesyl pyrophosphate synthasetarget
Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
Zoledronic acidHydroxylapatitetarget
Zoledronic acidMultidrug resistance-associated protein 1transporter
Alendronic acidFarnesyl pyrophosphate synthasetarget
Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Alendronic acidV-type proton ATPase catalytic subunit Atarget
Alendronic acidHydroxylapatitetarget
IbandronateFarnesyl pyrophosphate synthasetarget
IbandronateHydroxylapatitetarget
IbandronateGeranylgeranyl pyrophosphate synthasetarget
Clodronic acidADP/ATP translocase 2target
Clodronic acidADP/ATP translocase 1target
Clodronic acidADP/ATP translocase 3target
Clodronic acidHydroxylapatitetarget
Clodronic acidProstaglandin G/H synthase 2enzyme
FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
Risedronic acidFarnesyl pyrophosphate synthasetarget
Risedronic acidHydroxylapatitetarget
Risedronic acidProstaglandin G/H synthase 2enzyme
Etidronic acidHydroxylapatitetarget
Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
Etidronic acidV-type proton ATPase catalytic subunit Atarget
Etidronic acidADP/ATP translocase 1target
Etidronic acidADP/ATP translocase 2target
Etidronic acidADP/ATP translocase 3target
Tiludronic acidTyrosine-protein phosphatase non-receptor type 12target
Tiludronic acidV-ATPase Subunitstarget
Tiludronic acidHydroxylapatitetarget
Tiludronic acidAdenosine triphosphate (ATP)target
Tiludronic acidSerum albumincarrier
Tiludronic acidTyrosine-protein phosphatase non-receptor type 6target
Tiludronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Phosphonoacetic AcidAlkaline phosphatasetarget
Incadronic acidFarnesyl pyrophosphate synthasetarget
Incadronic acidCaspase-3target
Incadronic acidCaspase-4target
Incadronic acidCaspase-7target
TenofovirP-glycoprotein 1transporter
TenofovirSolute carrier family 22 member 6transporter
TenofovirSolute carrier family 22 member 8transporter
TenofovirMultidrug resistance-associated protein 4transporter
TenofovirNucleoside diphosphate kinase Aenzyme
TenofovirNucleoside diphosphate kinase Benzyme
TenofovirAdenylate kinase isoenzyme 1enzyme
TenofovirAdenylate kinase 2, mitochondrialenzyme
TenofovirReverse transcriptase/RNaseHtarget
TenofovirReverse transcriptasetarget
TenofovirDNA polymerasetarget
TenofovirSerum albumincarrier
CidofovirDNA polymerase catalytic subunittarget
CidofovirSolute carrier family 22 member 6transporter
CidofovirThymidine phosphorylaseenzyme