Povidone K30
Identification
- Brand Names
- Freshkote, Minidrops
- Generic Name
- Povidone K30
- DrugBank Accession Number
- DB14478
- Background
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.
- Type
- Small Molecule
- Groups
- Approved, Experimental
- Synonyms
- 1-vinylpyrrolidin-2-one homopolymer
- Plasdone K29-32
- Plasdone K29/32
- Polyvinylpyrrolidone K 30
- Polyvinylpyrrolidone K-29/32
- Polyvinylpyrrolidone K30
- Povidone K29-32
- Povidone K29/32
- PVP K-30
- PVP K30
- PVP-K 30
Pharmacology
- Indication
When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
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- Pharmacodynamics
Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties 2. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application 1.
- Mechanism of action
Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen 1. Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.
- Absorption
This pharmacokinetic data does not apply to povidone.
- Volume of distribution
This pharmacokinetic data does not apply to povidone.
- Protein binding
This pharmacokinetic data does not apply to povidone.
- Metabolism
This pharmacokinetic data does not apply to povidone.
- Route of elimination
This pharmacokinetic data does not apply to povidone.
- Half-life
This pharmacokinetic data does not apply to povidone.
- Clearance
This pharmacokinetic data does not apply to povidone.
- Adverse Effects
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- Toxicity
Oral LD50 in mouse, rat, and rabbit are >40 mg/kg, 100 mg/kg, and 1040 mg/kg, respectively MSDS. No cases of overdose in humans have been reported.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image FreshKote Lubricant Eye Drops Povidone K30 (20 g/1000mL) + Polyvinyl alcohol (27 g/1000mL) Solution / drops Ophthalmic Focus Laboratories, Inc. 2006-04-01 Not applicable US MiniDrops Povidone K30 (.6 mL/100mL) + Polyvinyl alcohol (1.4 mL/100mL) Liquid Ophthalmic Taiwan Biotech Co., Ltd. 1991-04-01 Not applicable US
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U725QWY32X
- CAS number
- 9003-39-8
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- Kramer SA: Effect of povidone-iodine on wound healing: a review. J Vasc Nurs. 1999 Mar;17(1):17-23. [Article]
- Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23. [Article]
- External Links
- Not Available
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Powder Cutaneous Powder Cutaneous 19.30 g Solution / drops Ophthalmic Liquid Ophthalmic Powder Not applicable 1 g/1g Drug delivery system Topical Drug delivery system Cutaneous Solution Ophthalmic 0.500 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at July 06, 2018 19:36 / Updated at December 01, 2022 11:28