Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions . Prezatide is used in cosmetic products for the skin and hair.... It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer are currently being investigated.
- Mechanism
- Curator reviewed · 6 references
Prezatide in complex with copper increases the synthesis and deposition of type I collagen and glycosaminoglycan. It also increases the expression of matrix metalloproteinase-2 as well as tissue inhibitor of matrix metalloproteinases-1 and -2, suggesting that it plays a role in the modulation of tissue remodeling. It is thought that prezatide's antioxidant activity is due to its ability to supply copper for superoxide dismutase and its anti inflammatory ability due to the blockage the of iron (Fe2+) release during injury. Prezatide also increases angiogenesis to injury sites. The precise mechanisms of these effects are unknown. It is also unknown whether prezatide's effects are due to the action of the tripeptide itself or its ability to localize and transport copper. Prezatide is known to be bound by heparin and heparin sulfate
- Primary indication
- Commonly used in cosmetic products for the skin and hair.Curator reviewed
- Formula / weight
- C14H23CuN6O4 · 402.921 g/mol (avg)
- Also known as
- CG-copper peptide · Copper tripeptide-1 · GHK complex with copper · GHK copper
Resolves to
NZWIFMYRRCMYMN-ACMTZBLWSA-MSMILES[Cu++].NCCCC[C@H](NC(=O)[C@H](CC1=CN=CN1)NC(=O)CN)C([O-])=OWhat you can answer from here — as of September 23, 2026
Which companies are running trials of Prezatide copper, in which indications and phases, and which of those programs are still active?
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