Nepidermin

Identification

Generic Name

Nepidermin

DrugBank Accession Number

DB14145

Background

Not Available

Type

Biotech

Groups

Experimental

Synonyms

• Beta-urogastrone
• Epidermal growth factor (human)
• Epidermal growth factor biosynthetic human
• Epidermal growth factor human
• H-EGF
• Human EGF
• Human epidermal growth factor
• Human urogastrone
• Nepidermin
• Nepidermina
• Népidermine
• Nepiderminum
• Recombinant human epidermal growth factor
• rhEGF
• Urogastrone

Pharmacology

Indication

Not Available

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Associated Conditions

• Burns first degree
• Diabetic Foot Ulcers (DFUs)
• Second Degree Burns
• Ulcers
• Wound site

Associated Therapies

• Skin Care

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

Products

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International/Other Brands

Easyef / Genesoft / Kang He Su / Regen-D

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
EASYDEW DW EGF Derma Needle 3000 Shot	Solution	0.000045 mg/45mg	Topical	Dn Company Co.,Ltd.	2018-03-01	Not applicable
Easydew EX Repair Control Repair Control Egf	Liquid	0.0002 g/20mL	Topical	Dn Company Co.,Ltd.	2018-02-01	Not applicable
EASYDEW EX REPAIR CONTROL REPAIR CONTROL EGF 3mL	Liquid	0.03 mg/3mL	Topical	Dn Company Co.,Ltd.	2018-07-01	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
ARTEMES 3R Effect Hyaluronic Ampoule	Nepidermin (0.05 mg/5mL) + Adenosine (0.002 g/5mL) + Nicotinamide (0.10 g/5mL)	Liquid	Topical	Dn Company Co.,Ltd.	2019-03-01	Not applicable
Artemes 3R effect hyaluronic mask	Nepidermin (0.33 mg/33g) + Adenosine (0.01 g/33g) + Nicotinamide (0.66 g/33g)	Patch	Topical	Dn Company Co.,Ltd.	2019-03-01	Not applicable
Cosmeceutical Mask Pack	Nepidermin (0.044 mg/22g) + Basic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)	Patch	Topical	YBK Investment, INC	2013-10-21	Not applicable
Cosmeceutical Mask Pack	Nepidermin (0.044 mg/22g) + Basic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)	Patch	Topical	YBK Investment, INC	2013-10-21	2013-10-29
Dermaheal Cosmeceutical Mask Pack Plus	Nepidermin (0.044 mg/22g) + Basic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)	Patch	Topical	YBK Investment, INC	2013-10-21	Not applicable
EASYDEW DW EGF Derma Oneshot Ampoule	Nepidermin (0.000001 mg/1.2mL) + Adenosine (0.00048 mg/1.2mL) + Nicotinamide (0.024 mg/1.2mL)	Liquid	Topical	Dn Company Co.,Ltd.	2018-03-01	Not applicable
Easydew EX Repair Control Active Soothing Serum	Nepidermin (0.00012 g/40mL) + Adenosine (0.016 g/40mL) + Nicotinamide (0.8 g/40mL)	Cream	Topical	Dn Company Co.,Ltd.	2018-02-01	Not applicable
Easydew EX Repair Control Renewal Moisture	Nepidermin (0.0001 g/50mL) + Adenosine (0.02 g/50mL) + Nicotinamide (1.0 g/50mL)	Cream	Topical	Dn Company Co.,Ltd.	2018-02-01	Not applicable
Le-Blen EGF Serum	Nepidermin (0.54 g/56.7g) + Sodium hyaluronate (0.4 g/56.7g)	Lotion	Topical	LeBlen Beauty Inc	2018-04-24	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
ARTEMES 3R Effect Hyaluronic Ampoule	Nepidermin (0.05 mg/5mL) + Adenosine (0.002 g/5mL) + Nicotinamide (0.10 g/5mL)	Liquid	Topical	Dn Company Co.,Ltd.	2019-03-01	Not applicable
Artemes 3R effect hyaluronic mask	Nepidermin (0.33 mg/33g) + Adenosine (0.01 g/33g) + Nicotinamide (0.66 g/33g)	Patch	Topical	Dn Company Co.,Ltd.	2019-03-01	Not applicable
Cosmeceutical Mask Pack	Nepidermin (0.044 mg/22g) + Basic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)	Patch	Topical	YBK Investment, INC	2013-10-21	Not applicable
Cosmeceutical Mask Pack	Nepidermin (0.044 mg/22g) + Basic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)	Patch	Topical	YBK Investment, INC	2013-10-21	2013-10-29
Dermaheal Cosmeceutical Mask Pack Plus	Nepidermin (0.044 mg/22g) + Basic Fibroblast Growth Factor (0.044 mg/22g) + Mecasermin (0.044 mg/22g) + Palmitoyl oligopeptide (0.044 mg/22g) + Prezatide copper (0.22 mg/22g) + Thioredoxin (0.044 mg/22g)	Patch	Topical	YBK Investment, INC	2013-10-21	Not applicable
EASYDEW DW EGF Derma Needle 3000 Shot	Nepidermin (0.000045 mg/45mg)	Solution	Topical	Dn Company Co.,Ltd.	2018-03-01	Not applicable
EASYDEW DW EGF Derma Oneshot Ampoule	Nepidermin (0.000001 mg/1.2mL) + Adenosine (0.00048 mg/1.2mL) + Nicotinamide (0.024 mg/1.2mL)	Liquid	Topical	Dn Company Co.,Ltd.	2018-03-01	Not applicable
Easydew EX Repair Control Active Soothing Serum	Nepidermin (0.00012 g/40mL) + Adenosine (0.016 g/40mL) + Nicotinamide (0.8 g/40mL)	Cream	Topical	Dn Company Co.,Ltd.	2018-02-01	Not applicable
Easydew EX Repair Control Renewal Moisture	Nepidermin (0.0001 g/50mL) + Adenosine (0.02 g/50mL) + Nicotinamide (1.0 g/50mL)	Cream	Topical	Dn Company Co.,Ltd.	2018-02-01	Not applicable
Easydew EX Repair Control Repair Control Egf	Nepidermin (0.0002 g/20mL)	Liquid	Topical	Dn Company Co.,Ltd.	2018-02-01	Not applicable

Categories

Drug Categories

• Amino Acids, Peptides, and Proteins
• Biological Factors
• EGF Family of Proteins
• Gastrointestinal Hormones
• Hormones
• Hormones, Hormone Substitutes, and Hormone Antagonists
• Intercellular Signaling Peptides and Proteins
• Peptides
• Proteins

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

TZK30RF92W

CAS number

62253-63-8

References

General References

Not Available

External Links

RxNav

1427157

Wikipedia

Nepidermin

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
3	Completed	Treatment	Diabetic Foot Ulcer Patients With Uncontrolled Diabetes Mellitus	1
3	Unknown Status	Treatment	Diabetic Foot Ulcers (DFUs) / Epidermal Growth Factor	1
3	Unknown Status	Treatment	Stomatitis	1
2	Completed	Prevention	Oral Mucositis	1
2	Completed	Treatment	Colorectal Carcinoma (CRC)	1
2	Not Yet Recruiting	Treatment	Neoplasms, Breast	1
2	Recruiting	Treatment	HER2/Neu+ Uterine Serous Carcinoma	1
1	Completed	Other	Healthy Subjects (HS)	1
1	Recruiting	Treatment	Periodontitis	1
1, 2	Recruiting	Treatment	Advanced Head and Neck Squamous Cell Carcinoma / Metastatic Non-Small Cell Lung Cancer / Non-Small Cell Lung Carcinoma (NSCLC) / PD-L1 positive / Recurrent Head and Neck Squamous Cell Carcinoma / Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 / Stage III Lung Cancer AJCC v8 / Stage IIIA Lung Cancer AJCC v8 / Stage IIIB Lung Cancer AJCC v8 / Stage IIIC Lung Cancer AJCC v8 / Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 / Stage IV Lung Cancer AJCC v8 / Stage IVA Lung Cancer AJCC v8 / Stage IVB Lung Cancer AJCC v8 / Unresectable Non-Small Cell Lung Carcinoma	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Patch	Topical
Solution	Topical	0.000045 mg/45mg
Liquid	Topical
Cream	Topical
Liquid	Topical	0.0002 g/20mL
Liquid	Topical	0.03 mg/3mL
Solution	Topical
Solution	Topical	0.5 mg/ml
Spray	Topical
Injection, powder, lyophilized, for solution	Intralesional
Lotion	Topical
Gel	Topical
Powder		0.075 mg/1vial

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

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Drug created on June 27, 2018 20:17 / Updated on February 21, 2021 18:54