Valomaciclovir stearate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Valomaciclovir stearate
Accession Number
DB15651
Description

Valomaciclovir stearate is under investigation in clinical trial NCT00831103 (A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 618.864
Monoisotopic: 618.446868992
Chemical Formula
C33H58N6O5
Synonyms
  • Valomaciclovir stearate
External IDs
  • A 174606.0
  • A-174606.0
  • ABT-606
  • EPB 348
  • MIV 606
  • MIV-606

Pharmacology

Pharmacology
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Indication
Not Available
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
506LI1B3A3
CAS number
195156-77-5
InChI Key
ACBSZTQIFTYFGH-IAPPQJPRSA-N
InChI
InChI=1S/C33H58N6O5/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-27(40)44-23-26(20-21-43-32(42)28(34)25(2)3)22-39-24-36-29-30(39)37-33(35)38-31(29)41/h24-26,28H,4-23,34H2,1-3H3,(H3,35,37,38,41)/t26-,28+/m1/s1
IUPAC Name
(2R)-4-{[(2S)-2-amino-3-methylbutanoyl]oxy}-2-[(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)methyl]butyl octadecanoate
SMILES
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CCOC(=O)[C@@H](N)C(C)C)CN1C=NC2=C1N=C(N)NC2=O

References

General References
Not Available
ChemSpider
2300861
ChEMBL
CHEMBL2105845
ZINC
ZINC000008214706

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentHerpes Zoster1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000371 mg/mLALOGPS
logP5.92ALOGPS
logP6.72ChemAxon
logS-6.2ALOGPS
pKa (Strongest Acidic)10.17ChemAxon
pKa (Strongest Basic)7.48ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area163.92 Å2ChemAxon
Rotatable Bond Count27ChemAxon
Refractivity173.82 m3·mol-1ChemAxon
Polarizability74.49 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on March 31, 2020 21:32 / Updated on February 21, 2021 18:55