Accession Number

Not Available

DrugDrug Description
CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
ValaciclovirAn guanine nucleoside antiviral used to treat herpes exacerbations.
AcyclovirA guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.
PentoxifyllineA methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs.
DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
GanciclovirA DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.
PenciclovirA topical nucleoside polymerase inhibitor used in the treatment of recurrent herpes labialis.
EntecavirA nucleoside analogue used in the treatment of chronic hepatitis B for patients with active viral replication, histological evidence of active disease, or persistent elevations in liver transaminases.
8-azaguanine8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
7,9-DimethylguanineNot Available
7-DeazaguanineNot Available
5'-S-methyl-5'-thioadenosineNot Available
GuanineNot Available
9-MethylguanineNot Available
PeldesinePeldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections.
7-cyano-7-deazaguanineNot Available
9-DeazahypoxanthineNot Available
9-DeazaguanineNot Available
Besifovir dipivoxilInvestigated for use/treatment in hepatitis (viral, B).
ValomaciclovirInvestigated for use/treatment in herpes zoster infections and viral infection.
6-O-benzylguanine6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others.
LobucavirLobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.
QueuineCurrent and on-going research suggests queuine is a natural biochemical compound that can be found endogenously in the human body and plays an essential role in the generation of other...
Valomaciclovir stearateValomaciclovir stearate is under investigation in clinical trial NCT00831103 (A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster).
BesifovirNot Annotated
TheophyllineA xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
DyphyllineA theophylline derivative used to treat asthma, bronchospasm, and COPD.
EnprofyllineUsed in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
AminophyllineA bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
OxtriphyllineA bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema.
Theobrominetheobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension.
FenethyllineNot Available
ValganciclovirAn antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS).
8-azaxanthineNot Available
XanthineA drug used to manage uncomplicated liver dysfunction in combination with orotic acid.
HypoxanthineHypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.
NaxifyllineInvestigated for use/treatment in congestive heart failure.
PropentofyllineInvestigated for use/treatment in alzheimer's disease.
3-isobutyl-1-methyl-7H-xanthineNot Available
Uric acidAt present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke.
XanthinolA vasodilatory niacin found in diet supplements.
DoxofyllineA methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms.
LisofyllineLisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus.
TonapofyllineTonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
RolofyllineRolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure.
ReproterolA short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma.
CafedrineCafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).
TheodrenalineTheodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).
DPCPXCPX has been used in trials studying the treatment of Cystic Fibrosis.
CT-2584CT-2584 has been used in trials studying the treatment of Prostate Cancer.
Ambroxol acefyllinateA bronchodilator indicated in the symptomatic treatment of bronchopulmonary disorders associated with bronchospasm.
BamifyllineA methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm.
ProxyphyllineNot Annotated
AcefyllineNot Annotated
EtamiphyllineNot Annotated
PentifyllineNot Annotated
BufyllineNot Annotated
BromotheophyllineBromotheophylline is used as a diuretic and also, in combination with DB00316, it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with...
FurafyllineFurafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline.
8-chlorotheophyllineWhen used in combination with DB01075 as the antiemetic DB00985, 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.
PCS-499PCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients).
LomifyllineNot Annotated
Drugs & Drug Targets
CaffeineAdenosine receptor A1target
CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CaffeineAdenosine receptor A2atarget
CaffeineCytochrome P450 1A2enzyme
CaffeineRyanodine receptor 1target
CaffeineCytochrome P450 3A4enzyme
CaffeineCytochrome P450 2E1enzyme
CaffeineCytochrome P450 2C8enzyme
CaffeineCytochrome P450 2C9enzyme
CaffeineCytochrome P450 1A1enzyme
CaffeineCytochrome P450 1B1enzyme
CaffeineCytochrome P450 2D6enzyme
CaffeineCyclic nucleotide phosphodiesterasetarget
CaffeineDNA-dependent protein kinase catalytic subunittarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
CaffeineInositol 1,4,5-trisphosphate receptortarget
CaffeineSerine-protein kinase ATMtarget
CaffeineATP-binding cassette sub-family G member 2transporter
CaffeineAdenosine receptor A2btarget
CaffeineAdenosine receptor A3target
CaffeinePhosphodiesterase enzymestarget
ValaciclovirThymidine kinasetarget
ValaciclovirDNA polymerase catalytic subunittarget
ValaciclovirSolute carrier family 15 member 1transporter
ValaciclovirSolute carrier family 15 member 2transporter
ValaciclovirSolute carrier family 22 member 8transporter
ValaciclovirSolute carrier family 22 member 6transporter
ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
ValaciclovirIleal sodium/bile acid cotransportertransporter
ValaciclovirGuanylate kinaseenzyme
ValaciclovirThymidine kinaseenzyme
AcyclovirDNA polymerase catalytic subunittarget
AcyclovirDNA polymerase catalytic subunittarget
AcyclovirSolute carrier family 22 member 1transporter
AcyclovirSolute carrier family 22 member 6transporter
AcyclovirSolute carrier family 22 member 8transporter
AcyclovirIleal sodium/bile acid cotransportertransporter
AcyclovirMultidrug and toxin extrusion protein 1transporter
AcyclovirMultidrug and toxin extrusion protein 2transporter
AcyclovirThymidine kinaseenzyme
AcyclovirGuanylate kinaseenzyme
AcyclovirNucleoside diphosphokinaseenzyme
AcyclovirPyruvate Kinasesenzyme
AcyclovirCreatine Kinasesenzyme
AcyclovirPhosphoglycerate Kinasesenzyme
AcyclovirSuccinyl-CoA Synthetasesenzyme
AcyclovirPhosphoenolpyruvate Carboxykinasesenzyme
AcyclovirAdenylosuccinate Synthetasesenzyme
AcyclovirSerum albumincarrier
PentoxifyllineAdenosine receptor A1target
PentoxifyllineAdenosine receptor A2atarget
PentoxifyllineCytochrome P450 1A2enzyme
PentoxifyllinePhosphodiesterase enzymestarget
DimenhydrinateHistamine H1 receptortarget
GanciclovirDNA polymerase catalytic subunittarget
GanciclovirSolute carrier family 22 member 1transporter
GanciclovirSolute carrier family 22 member 6transporter
GanciclovirSolute carrier family 22 member 8transporter
GanciclovirSolute carrier family 22 member 7transporter
GanciclovirMultidrug and toxin extrusion protein 1transporter
GanciclovirMultidrug and toxin extrusion protein 2transporter
GanciclovirThymidine kinasetarget
PenciclovirDNA polymerase catalytic subunittarget
PenciclovirThymidine kinasetarget
8-azaguaninePurine nucleoside phosphorylasetarget
8-azaguanineCytochrome P450 1A2enzyme
7,9-DimethylguanineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
5'-S-methyl-5'-thioadenosineModification methylase RsrItarget
5'-S-methyl-5'-thioadenosineS-methyl-5'-thioadenosine phosphorylasetarget
GuaninePurine nucleoside phosphorylasetarget
GuaninePurine nucleoside phosphorylase 2target
GuanineXanthine phosphoribosyltransferasetarget
GuanineGTP cyclohydrolase 1target
GuaninePurine nucleoside phosphorylasetarget
9-MethylguanineDihydroneopterin aldolasetarget
9-MethylguanineCytochrome P450 1A2enzyme
PeldesinePurine nucleoside phosphorylasetarget
7-cyano-7-deazaguanineQueuine tRNA-ribosyltransferasetarget
9-DeazahypoxanthinePurine nucleoside phosphorylasetarget
9-DeazaguanineHypoxanthine-guanine phosphoribosyltransferasetarget
9-DeazaguanineCytochrome P450 1A2enzyme
Besifovir dipivoxilDNA polymerasetarget
6-O-benzylguanineCytochrome P450 3A4enzyme
QueuineQueuine tRNA-ribosyltransferaseenzyme
TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
TheophyllineAdenosine receptor A2btarget
TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
TheophyllineAdenosine receptor A1target
TheophyllineAdenosine receptor A2atarget
TheophyllineCytochrome P450 1A2enzyme
TheophyllineAdenosine deaminaseenzyme
TheophyllineCytochrome P450 2E1enzyme
TheophyllineCytochrome P450 3A4enzyme
TheophyllineSolute carrier family 22 member 7transporter
TheophyllineCytochrome P450 1A1enzyme
TheophyllineCytochrome P450 1B1enzyme
TheophyllineCytochrome P450 2D6enzyme
TheophyllineHistone deacetylase 2target
TheophyllineMinor histocompatibility antigen H13target
TheophyllineNodal modulator 1target
TheophyllinePoly [ADP-ribose] polymerase 1target
TheophyllineProtein RIC-3target
TheophyllineTubulin monoglycylase TTLL3target
DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DyphyllineAdenosine receptor A1target
DyphyllineAdenosine receptor A2atarget
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
EnprofyllineAdenosine receptor A2btarget
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
EnprofyllineAdenosine receptor A1target
EnprofyllineAdenosine receptor A2atarget
EnprofyllineAdenosine receptor A3target
AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AminophyllineAdenosine receptor A3target
AminophyllineAdenosine receptor A1target
AminophyllineCytochrome P450 1A2enzyme
AminophyllineCytochrome P450 2E1enzyme
AminophyllineCytochrome P450 3A4enzyme
AminophyllineHistone deacetylase 2target
OxtriphyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
OxtriphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
OxtriphyllineAdenosine receptor A2atarget
OxtriphyllineAdenosine receptor A1target
OxtriphyllineCytochrome P450 1A2enzyme
OxtriphyllineSolute carrier family 22 member 7transporter
OxtriphyllineHistone deacetylase 2target
TheobromineCytochrome P450 1A2enzyme
TheobromineCytochrome P450 2E1enzyme
TheobromineAdenosine receptor A1target
TheobromineAdenosine receptor A2atarget
TheobrominecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
FenethyllineCytochrome P450 1A2enzyme
ValganciclovirSolute carrier family 15 member 1transporter
ValganciclovirSolute carrier family 15 member 2transporter
ValganciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
8-azaxanthineUric acid degradation bifunctional proteintarget
XanthinePurine nucleoside phosphorylase 2target
XanthineXanthine phosphoribosyltransferasetarget
XanthineCytochrome P450 1A2enzyme
HypoxanthinePurine nucleoside phosphorylasetarget
HypoxanthineCytochrome P450 1A2enzyme
NaxifyllineAdenosine receptor A1target
PropentofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
PropentofyllineCytochrome P450 1A2enzyme
3-isobutyl-1-methyl-7H-xanthinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
3-isobutyl-1-methyl-7H-xanthinecGMP-inhibited 3',5'-cyclic phosphodiesterase Btarget
3-isobutyl-1-methyl-7H-xanthineHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7Atarget
3-isobutyl-1-methyl-7H-xanthinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
3-isobutyl-1-methyl-7H-xanthineHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9Atarget
3-isobutyl-1-methyl-7H-xanthineHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8Atarget
3-isobutyl-1-methyl-7H-xanthinecGMP-dependent 3',5'-cyclic phosphodiesterasetarget
3-isobutyl-1-methyl-7H-xanthineRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
Uric acidSolute carrier family 22 member 6transporter
Uric acidSolute carrier family 22 member 8transporter
Uric acidGlycogen phosphorylase, liver formtarget
Uric acidSolute carrier family 2, facilitated glucose transporter member 9transporter
Xanthinol60S ribosomal protein L3target
XanthinolNAD(P) transhydrogenase, mitochondrialtarget
XanthinolGlyceraldehyde-3-phosphate dehydrogenasetarget
XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
Xanthinol2-oxoglutarate dehydrogenase, mitochondrialtarget
XanthinolMalate dehydrogenase, mitochondrialtarget
DoxofyllineAdenosine receptor A2atarget
DoxofyllineBeta-2 adrenergic receptortarget
DoxofyllineCytochrome P450 1A2enzyme
DoxofyllinecGMP-dependent 3',5'-cyclic phosphodiesterasetarget
LisofyllineCytochrome P450 1A2enzyme
TonapofyllineAdenosine receptor A1target
RolofyllineAdenosine receptor A1target
Ambroxol acefyllinateCytochrome P450 3A Subfamilyenzyme
BamifyllineCytochrome P450 1A2enzyme
ProxyphyllineCytochrome P450 1A2enzyme
AcefyllineCytochrome P450 1A2enzyme
EtamiphyllineCytochrome P450 1A2enzyme
PentifyllineCytochrome P450 1A2enzyme
BufyllineCytochrome P450 1A2enzyme
BromotheophyllineCytochrome P450 1A2enzyme
FurafyllineCytochrome P450 1A2enzyme
8-chlorotheophyllineAdenosine receptor A2atarget
8-chlorotheophyllineCytochrome P450 1A2enzyme