Pitofenone
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
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Identification
- Summary
Pitofenone is a medication used in the treatment of spastic pain caused by menstrual cramps, the digestive system, and the urinary tract.
- Generic Name
- Pitofenone
- DrugBank Accession Number
- DB15947
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 367.445
Monoisotopic: 367.178358289 - Chemical Formula
- C22H25NO4
- Synonyms
- Pitofenona
- Pitofenone
- Pitofenonum
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Menstrual cramps Combination Product in combination with: Fenpiverinium (DB13759) •••••••••••• •••••• Used in combination to treat Spastic pain of the biliary tract Combination Product in combination with: Fenpiverinium (DB13759) •••••••••••• •••••• Used in combination to treat Spastic pain of the intestine Combination Product in combination with: Fenpiverinium (DB13759) •••••••••••• •••••• Used in combination to treat Spastic pain of the stomach Combination Product in combination with: Fenpiverinium (DB13759) •••••••••••• •••••• Used in combination to treat Spastic pain of the urinary tract Combination Product in combination with: Fenpiverinium (DB13759) •••••••••••• •••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Pitofenone hydrochloride HE1ZA4ZBEX 1248-42-6 ZRFIFDFEDPJBII-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image จีนาลแกน Pitofenone (5 MG) + Fenpiverinium (0.1 MG) Tablet บริษัท พอนด์ เคมีคอล จำกัด 2015-11-19 2020-09-01 Thailand ฟาแกน Pitofenone (5 MG) + Fenpiverinium (0.1 MG) Tablet บริษัท เอเชี่ยนยูเนี่ยนแล็บบอราตอรี่ จำกัด จำกัด 1989-01-23 Not applicable Thailand ฟิลิแกนเม็ด Pitofenone (5 MG) + Fenpiverinium (0.1 MG) Tablet บริษัท วี แอนด์ พี ลาบอราตอรี่ จำกัด จำกัด 1990-04-11 Not applicable Thailand
Categories
- ATC Codes
- A03DA02 — Pitofenone and analgesics
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- M09N8K7YJY
- CAS number
- 54063-52-4
- InChI Key
- NZHMAQSCHUSSSJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H25NO4/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-16H2,1H3
- IUPAC Name
- methyl 2-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}benzoate
- SMILES
- COC(=O)C1=CC=CC=C1C(=O)C1=CC=C(OCCN2CCCCC2)C=C1
References
- General References
- FDA Thailand: Genalgan (Fenpiverinium, Pitofenone) Oral Tablet [Link]
- External Links
- ChemSpider
- 108096
- ChEBI
- 135547
- ChEMBL
- CHEMBL2104821
- ZINC
- ZINC000000538207
- Wikipedia
- Pitofenone
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0128 mg/mL ALOGPS logP 3.94 ALOGPS logP 4.15 Chemaxon logS -4.5 ALOGPS pKa (Strongest Basic) 8.63 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 55.84 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 105.28 m3·mol-1 Chemaxon Polarizability 41.18 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014r-0119000000-c49a5d07d0b4c7d2496a Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0fsi-0009000000-0a451d4ce1535d4e9f15 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-066s-1569000000-b96876f713eb5243862f Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-029i-1539000000-47954053df2b7576ea3d Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0bta-3911000000-24a0014fbaa2aa0049b9 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-002b-1981000000-d749ac0fe65cff198aad Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 197.1903641 predictedDarkChem Lite v0.1.0 [M+H]+ 198.1787641 predictedDarkChem Lite v0.1.0 [M+Na]+ 196.9962641 predictedDarkChem Lite v0.1.0
Drug created at November 26, 2020 14:35 / Updated at May 07, 2021 21:09