NAV

Clostebol acetate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Clostebol acetate is a steroid combined with neomycin in topical formulations for the treatment of minor skin wounds.

Generic Name
Clostebol acetate
DrugBank Accession Number
DB15984
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 364.91
Monoisotopic: 364.1805225
Chemical Formula
C21H29ClO3
Synonyms
  • 4-Chlorotestosterone acetate
  • Chlorotestosterone acetate
  • Clostebol acetate
External IDs
  • 212-720-4
  • NSC-72159
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
TROFODERMINClostebol acetate (5 MG/ML) + Neomycin sulfate (5 MG/ML)SprayCutaneousLaboratorio Farmaceutico Sit Specialita Igienico Terapeutiche S.R.L.2014-07-08Not applicableItaly flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
780ZZX4P14
CAS number
855-19-6
InChI Key
XYGMEFJSKQEBTO-KUJXMBTLSA-N
InChI
InChI=1S/C21H29ClO3/c1-12(23)25-18-7-6-14-13-4-5-16-19(22)17(24)9-11-20(16,2)15(13)8-10-21(14,18)3/h13-15,18H,4-11H2,1-3H3/t13-,14-,15-,18-,20+,21-/m0/s1
IUPAC Name
(1S,3aS,3bR,9aR,9bS,11aS)-6-chloro-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
SMILES
[H][C@@]12CC[C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=C(Cl)C(=O)CC[C@]12C

References

General References
  1. AIFA: Trofodermin (Clostebol Acetate, Neomycin Sulfate) Topical Cream [Link]
KEGG Compound
C18374
ChemSpider
12762
RxNav
236522
ChEBI
81712
ChEMBL
CHEMBL519327
ZINC
ZINC000003881980
Wikipedia
Clostebol_acetate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamTopical
SprayCutaneous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00309 mg/mLALOGPS
logP3.95ALOGPS
logP4.2Chemaxon
logS-5.1ALOGPS
pKa (Strongest Basic)-6.2Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area43.37 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity98.37 m3·mol-1Chemaxon
Polarizability40.68 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-0009000000-d7cd3f5462a2bef94471
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-03di-3009000000-4bfbb956078a481cbbda
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0avi-0429000000-243774a2605c6dfc5e24
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a59-9000000000-2e23effa55333ba44173
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0bu3-9002000000-05444d167255ce204d58
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0ab9-0983000000-7881d8eb57467b88d82e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-183.16649
predicted
DeepCCS 1.0 (2019)
[M+H]+185.0619
predicted
DeepCCS 1.0 (2019)
[M+Na]+190.83989
predicted
DeepCCS 1.0 (2019)

Drug created at December 10, 2020 15:41 / Updated at May 07, 2021 21:09