- Gonadal Hormones
- Accession Number
Hormones produced by the GONADS, including both steroid and peptide hormones. The major steroid hormones include ESTRADIOL and PROGESTERONE from the OVARY, and TESTOSTERONE from the TESTIS. The major peptide hormones include ACTIVINS and INHIBINS.
Drug Drug Description Conjugated estrogens A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis. Progesterone A hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. Medroxyprogesterone acetate A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty. Testosterone A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. Estrone An estrogen used to treat perimenopausal and postmenopausal symptoms. Estradiol An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. Fulvestrant An estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. Ethinylestradiol An estradiol used as a contraceptive. Nandrolone phenpropionate For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the... Trilostane Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Estramustine An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. Mestranol A synthetic estradiol found in oral contraceptive pills for contraception and the treatment of other conditions in the female reproductive system, such as dysmenorrhea and dysfunctional uterine bleeding. Testosterone propionate A slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles. 19-norandrostenedione The claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated. 5-androstenedione 5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance, and its... Bolasterone Not Available 1-Testosterone 1-Testosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring. 4-Hydroxytestosterone 4-Hydroxytestosterone is testosterone substituted with a hydroxy group on the fourth carbon atom. It is an anabolic steroid with no therapeutic indications, which is prohibited from use in sports by... Clostebol Not Available Androstenediol Androstenediol is an intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted... Androstenedione A delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as... Boldenone Boldenone is an anabolic steroid developed for veterinary use, mostly for treatment of horses. It is not indicated for use in humans in the US and is only available through... Bolandiol Not Available Calusterone An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was... Prasterone A steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy. Equilin For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and... EM-1745 Not Available 2-Methoxyestradiol For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis. Pregnenolone A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. Stanolone A potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure... Equilenin Equilenin is an estrogenic steroid produced by horses. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the urine... Afimoxifene For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring. Estriol Used as a test to determine the general health of an unborn fetus. Estrone sulfate An estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. Quinestrol Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer. Oleoyl-estrone For the treatment of obesity. 16-Bromoepiandrosterone Investigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria. HE3286 For the treatment of rheumatoid arthritis and type 2 diabetes. Prasterone sulfate Investigated for use/treatment in asthma and burns and burn infections. Trestolone Investigated for use/treatment in contraception and male hormonal deficiencies/abnormalities. Istaroxime Investigated for use/treatment in heart disease. Fluasterone Investigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity. Methyltestosterone A synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females. Hydroxyprogesterone caproate A synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. 2-Hydroxyestradiol 2-Hydroxyestradiol is classified as an endogenous steroid, catechol estrogen, and metabolite of estradiol. It is also a positional isomer of estriol. Testosterone succinate Not Available Nandrolone decanoate An anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass. Formestane For the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Dienogest An oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol. Synthetic Conjugated Estrogens, A A mixture of estrogens used to treat a variety of postmenopausal symptoms, including vaginal atrophy and dyspareunia. Synthetic Conjugated Estrogens, B A mixture of estrogens used to treat a variety of postmenopausal symptoms, including vaginal dryness. Polyestradiol phosphate Polymeric phosphoric acid ester of estradiol. Mibolerone Mibolerone is a potent anabolic steroid which is both higher affinity and more selective for the androgen receptor than metribolone. Atamestane Atamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent. Estetrol Estetrol has been investigated for the treatment and basic science of Prostatic Neoplasms. Promestriene Promestriene has been used in trials studying the prevention of Hypospadias. Nandrolone Nandrolone, also known as 19-nortestosterone or 19-norandrostenolone, is a synthetic anabolic-androgenic steroid (AAS) derived from testosterone. Oxabolone cipionate Used as a performance enhancing drug illicitly in athletes. Moxestrol Not Annotated Mesterolone Mesterolone is a synthetic anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). It is inactivated by 3α-hydroxysteroid dehydrogenase in skeleta muscules so it is considered a weak androgen. It is... Flumedroxone Not Annotated Metenolone Not Annotated Testosterone cypionate An androgen used to treat low or absent testosterone. Testosterone enanthate An androgen used to treat low or absent testosterone. Testosterone undecanoate An androgen used to treat low or absent testosterone. Testosterone enantate benzilic acid hydrazone Not Annotated Estradiol benzoate Estradiol benzoate is not currently available in any FDA or Health Canada approved products. Estradiol cypionate An estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism. Estradiol dienanthate Estradiol dienanthate is not currently available in any FDA or Health Canada approved products. Estradiol valerate An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception. Trestolone acetate Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate... Boldenone undecylenate Not Annotated Estradiol sulfamate Investigated for use/treatment in endometriosis. Epitestosterone Epitestosterone is the 17-alpha isomer of testosterone, derived from pregnenolone via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone... Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072]. ICI-164384 Not Available Fluoroestradiol F-18 A radiolabeled analog of estradiol used as a contrast agent in the PET imaging of estrogen receptor-positive breast cancer lesions. Algestone acetophenide Not Annotated
- Drugs & Drug Targets