Quinolines
- Name
- Quinolines
- Accession Number
- DBCAT000788
- Description
Cyclic compounds that include atoms other than carbon in their ring structure.
- ATC Classification
- Drugs
Drug Drug Description Moxifloxacin A fluoroquinolone antibiotic used to treat various bacterial infections. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Grepafloxacin A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Amodiaquine An antimalarial drug. Lomefloxacin A fluoroquinolone used to prevent and treat a wide variety of infections in the body. Primaquine An antimalarial indicated to prevent relapse of vivax malaria. Levofloxacin A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Tafenoquine An antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria. Ivacaftor A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. Bedaquiline A diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug resistant tuberculosis (MDR-TB). Kynurenic Acid Kynurenic Acid is under investigation in clinical trial NCT02340325 (FS2 Safety and Tolerability Study in Healthy Volunteers). Chiniofon Not Annotated Oxycinchophen Not Annotated Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Casimiroin Casimiroin is a quinone reductase 2 inhibitor isolated from Casimiroa edulis. Cinchocaine An anesthetic used for local or regional anesthesia. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Enoxacin For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria... Pefloxacin An antibiotic used to treat a variety of bacterial infections. Trovafloxacin An antibiotic used to treat gonorrhea and chlamydia. Nedocromil A pyrano quinoline used to treat allergic conjunctivitis. Imiquimod A toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata. Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Rosoxacin For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Gatifloxacin A fourth generation fluoroquinolone used to treat a wide variety of infections in the body. Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Oxamniquine For treatment of Schistosomiasis caused by Schistosoma mansoni Gemifloxacin A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Sparfloxacin A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. Chloroxine An antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp. Procaterol A beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Temafloxacin For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. Nitroxoline Nitroxoline is an antibiotic agent. 5,7-Dichlorokynurenic acid Not Available Pyrroloquinoline Quinone A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES. [PubChem] Dequalinium A quaternary ammonium cation antimicrobial agent used to treat common infections of the mouth and throat, as well as vaginal candidiasis. Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. 2-Hydroxyquinoline Not Available Clioquinol An antifungal cream used to treat a variety of fungal infections. Sitamaquine Investigated for use/treatment in infectious and parasitic disease (unspecified). Tipifarnib Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors. Indacaterol An inhaled long-acting beta-2 adrenergic agonist used to relax bronchial smooth muscle and improve symptoms and airflow obstruction caused by Chronic Obstructive Pulmonary Disease (COPD) and moderate to severe asthma. Rilapladib Investigated for use/treatment in atherosclerosis and cardiovascular disorders. LGD2941 For the treatment and prevention of osteoporosis. OPC-14523 Investigated for use/treatment in bulimia, depression, and obsessive-compulsive disorders. Technetium Tc-99m ciprofloxacin Investigated for use/treatment in infectious and parasitic disease (unspecified). Mavorixafor Investigated for use/treatment in HIV infection. Pelitinib Investigated for use/treatment in colorectal cancer and lung cancer. Tasquinimod Investigated for use/treatment in prostate cancer. Dovitinib Investigated for use/treatment in multiple myeloma and solid tumors. Garenoxacin Investigated for use/treatment in bacterial infection. Nemonoxacin Investigated for use/treatment in bacterial infection and pneumonia. Quarfloxin Investigated for use/treatment in leukemia (lymphoid). Laquinimod Investigated for use/treatment in multiple sclerosis. Besifloxacin A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. Pyrvinium An anthelmintic agent used for the treatment of pinworm infestations. 2-heptyl-4-hydroxyquinoline N-oxide Not Available LGD-2226 An androgen receptor modulator. 1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone Not Available Flumequine Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. Finafloxacin Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1... Quinagolide A dopamine D2 receptor agonist used for the treatment of hyperprolactinemia. Elvitegravir An antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Diiodohydroxyquinoline Used in the treatment of amoebiasis. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Alatrofloxacin A fluoroquinolone antibiotic used to treat a variety of bacterial infections. Oxyquinoline A medication used in combination with other medications to restore vaginal pH. Roquinimex Roquinimex is investigated to be used as a treatment of a number of cancers and autoimmune conditions. As well, roquinimex is researched to be used as adjuvant therapy after bone... Buquinolate Not Annotated Danofloxacin Danofloxacin is an antibiotic agent from the family of the fluoroquinolones used in veterinary medicine. Decoquinate Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites. Enrofloxacin Enrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant... Marbofloxacin Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. It is used in veterinary medicine. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available... Nequinate Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. Nequinate belongs to the family of Hydroquinolones. These are compounds containing an hydrogenated quinoline bearing a ketone group. Orbifloxacin Orbifloxacin is a fluoroquinolone antibiotic. It is marketed by Schering-Plough Animal Health and approved for certain infections in dogs. Pradofloxacin Pradofloxacin is a 3rd generation fluoroquinolone antibiotic developed by Bayer HealthCare AG, Animal Health GmBH. It was approved by the European Commission in April 2011 for bacterial infections in dogs... Sarafloxacin Sarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada. Difloxacin Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced... Rebamipide A gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa. Pavinetant Pavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia. Pazufloxacin Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol). Prulifloxacin A broad-spectrum fluoroquinolone antibiotic used to treat a variety of susceptible bacterial infections. Delafloxacin A fluoroquinolone antibiotic used to treat skin and skin structure infections. Setrobuvir Setrobuvir has been used in trials studying the treatment of Hepatitis C, Chronic. Abediterol Abediterol has been used in trials studying the treatment of Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Chronic Obstructive Pulmonary Disease (COPD) and Asthma. GSK-256066 Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others. LY-3023414 LY3023414 has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, BREAST CANCER, and Advanced Cancer, among others. PSI-697 PSI-697 has been used in trials studying the treatment of Scleritis. Nadifloxacin A topical fluoroquinolone used in the treatment of acne and topical bacterial skin infections. Zabofloxacin Zabofloxacin has been used in trials studying the treatment of Community Acquired Pneumonia and Chronic Obstructive Pulmonary Disease. Batefenterol Batefenterol has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. CP-609754 LNK 754 has been investigated in Mild Alzheimer's Disease. Ozenoxacin A quinolone antibiotic used to treat impetigo caused by susceptible bacteria. Tilbroquinol Tilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit... Sitafloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections. Chlorquinaldol Chlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment... Broxyquinoline Not Annotated Oxolinic acid Not Annotated Ipidacrine Not Annotated Hydroquinine Not Annotated Rufloxacin A fluoroquinolone antibiotic indicated in the treatment of susceptible respiratory infections and uncomplicated cystitis. LGD-3303 An androgen receptor modulator. Clinafloxacin Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of... Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Pyrotinib Pyrotinib is under investigation in clinical trial NCT03756064 (Neoadjuvant Study of Pyrotinib in Patients With HER2 Positive Breast Cancer). Hydroquinidine A medication indicated in the maintenance of a normal sinus rhythm, as well as the treatment and prevention of abnormal rhythm. Zavegepant Zavegepant is an antagonist of the calcitonin gene-related peptide (CGRP) receptor currently in phase 3 trials in an intranasal formulation for the treatment of migraine. If FDA approved, it will... Carmoterol A long acting beta-2 agonist indicated in the treatment of COPD, asthma, and chronic bronchitis. Cloxyquin Not Annotated Desidustat Desidustat is under investigation in clinical trial NCT04012957 (Desidustat in the Treatment of Anemia in CKD). Levonadifloxacin Levonadifloxacin is under investigation in clinical trial NCT03405064 (Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)). Naphthoquine Naphthoquine is under investigation in clinical trial NCT01930331 (Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO). TNP-2092 TNP-2092 is under investigation in clinical trial NCT03964493 (TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection). Reproxalap Reproxalap (previously ADX 102 or NS-2) is a small molecule inhibitor being developed by Aldeyra Therapeutics investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjögren-Larsson syndrome. NS-2... Tosufloxacin Not Annotated Ethoxyquin Not Annotated JTC-801 free base An antagonist of nociceptin receptor and analgesic agent, evaluated for its use in cancer treatment. NSC-663284 NSC-663284 is a potent quinolinedione Cdc25 phosphatase inhibitor. - Drugs & Drug Targets