Dry Eyes

Also known as: Xerophthalmia / Xeropthalmia / Dry Eye Symptoms / Eyes Dry / Eye Dryness / Dryness of eyes / Dry Eye / Dryness of the eyes / Decreased lacrimation / Tear film insufficiency, unspecified / Tear film insufficiency (disorder) / Tear film insufficiency, NOS / Xerophthalmia (disorder) / Vitamin A deficiency with xerophthalmia (disorder) / (Dry eye syndrome) or (tear film insufficiency) or (gritty eye) / Conjunctival xerosis (& [xerophthalmia]) / Dry eyes (finding) / Dry eye NOS / Dry eye (finding)

DrugDrug NameDrug Description
DB02579Acrylic AcidA drug used in combination with benzalkonium for eye disinfection and lubrication.
DB15649CarbomerNot Annotated
DB14091Carbomer homopolymer type CA medication in artificial tears for the treatment of dry eyes.
DB05384Carbopol 974PA polymer used as a lacrimal substitute to treat symptoms associated with dry eyes.
DB11059CarboxymethylcelluloseA compound used as an ophthalmic lubricant.
DB14357ChamomileChamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
DB09255DextranA low molecular weight dextran used as an adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma, as well as the prophylaxis of venous thrombosis and pulmonary embolism during high-risk medical procedures.
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB08818Hyaluronic acidA glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.
DB11075HypromelloseAn ingredient used in a wide variety of medications, and is not an approved medication.
DB09287Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
DB11077Polyethylene glycol 400An ingredient used in a wide variety of medications, and is not an approved medication.
DB11063Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
DB11060Polyvinyl alcoholA compound used as an ophthalmic lubricant.
DB11061PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
DB01839Propylene glycolA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
DB06764TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.
DB03904UreaA keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.
DB09322Zinc sulfateA drug used to replenish low levels of zinc or prevent zinc deficiency, or to test for zinc deficiency.
DrugDrug NameTargetType
DB02579Acrylic AcidBeta-lactamase SHV-1target
DB11059CarboxymethylcelluloseSolute carrier family 2, facilitated glucose transporter member 1target
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB09462GlycerinMaleylacetoacetate isomerasetarget
DB09462GlycerinAquaporin-7transporter
DB09462GlycerinAquaporin-9transporter
DB09462GlycerinGlycerol uptake facilitator proteintransporter
DB08818Hyaluronic acidCD44 antigentarget
DB08818Hyaluronic acidIntercellular adhesion molecule 1target
DB08818Hyaluronic acidHyaluronan mediated motility receptortarget
DB08818Hyaluronic acidNeurocan core proteintarget
DB08818Hyaluronic acidVersican core proteintarget
DB08818Hyaluronic acidComplement component 1 Q subcomponent-binding protein, mitochondrialtarget
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 1target
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 3target
DB08818Hyaluronic acidHyaluronan-binding protein 2target
DB08818Hyaluronic acidLayilintarget
DB08818Hyaluronic acidStabilin-2target
DB08818Hyaluronic acidTumor necrosis factor-inducible gene 6 proteintarget
DB08818Hyaluronic acidInterphotoreceptor matrix proteoglycan 2target
DB08818Hyaluronic acidIntracellular hyaluronan-binding protein 4target
DB08818Hyaluronic acidHyaluronidase enzymesenzyme
DB08818Hyaluronic acidMultidrug resistance-associated protein 5transporter
DB08818Hyaluronic acidLymphatic vessel endothelial hyaluronic acid receptor 1target
DB11075HypromelloseEpithelial cell adhesion moleculetarget
DB09287Polyethylene glycolP-glycoprotein 1transporter
DB11077Polyethylene glycol 400Oxidoreductase HTATIP2target
DB11077Polyethylene glycol 400Cytochrome P450 4A11enzyme
DB11077Polyethylene glycol 400Alcohol dehydrogenase class-3enzyme
DB11077Polyethylene glycol 400Sulfotransferase 1A1enzyme
DB11077Polyethylene glycol 400Ectonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB11077Polyethylene glycol 400P-glycoprotein 1transporter
DB01839Propylene glycolB12-independent glycerol dehydratasetarget
DB06764TetryzolineAlpha-1 adrenergic receptorstarget
DB06764TetryzolineAlpha-2 adrenergic receptorstarget
DB03904UreaArginase-1target
DB03904UreaCarbonic anhydrase 2target
DB03904UreaCatenin beta-1target
DB03904UreaSulfoxide reductase catalytic subunit YedYtarget
DB03904UreaUrea transporter 2transporter
DB03904UreaUrea transporter 1transporter
DB03904UreaDihydrofolate reductasetarget
DB09322Zinc sulfateAlkaline phosphatase, placental-likeenzyme
DrugDrug NamePhaseStatusCount
DB01234Dexamethasone0Enrolling by Invitation1
DB14596Loteprednol etabonate0Enrolling by Invitation1
DB11077Polyethylene glycol 4000Completed1
DB11078Propylene glycol0Completed1
DB00877Sirolimus0Completed1
DB09145Water0Completed1
DB01234Dexamethasone1Completed1
DB09357Dexpanthenol1Completed1
DB08818Hyaluronic acid1Completed1
DB00030Insulin human1Recruiting1
DB12373Isunakinra1Completed1
DB00684Tobramycin1Completed1
DB00484Brimonidine1 / 2Terminated1
DB00003Dornase alfa1 / 2Terminated2
DB00028Human immunoglobulin G1 / 2Completed1
DB01839Propylene glycol1 / 2Recruiting1
DB00484Brimonidine2Completed1
DB06168Canakinumab2Completed1
DB15649Carbomer2Recruiting1
DB11059Carboxymethylcellulose2Completed1
DB13926Cenegermin2Completed1
DB00091Cyclosporine2Completed2
DB01234Dexamethasone2Completed1
DB15919Diquafosol2Completed1
DB00254Doxycycline2Completed2
DB08818Hyaluronic acid2Not Yet Recruiting1
DB11075Hypromellose2Completed1
DB11075Hypromellose2Recruiting1
DB00465Ketorolac2Completed1
DB11611Lifitegrast2Completed1
DB11611Lifitegrast2Recruiting1
DB14596Loteprednol etabonate2Completed1
DB11228Methylcellulose2Completed1
DB11062Octisalate2Completed1
DB09535Octocrylene2Completed1
DB11077Polyethylene glycol 4002Completed2
DB11078Propylene glycol2Completed2
DB11656Rebamipide2Completed1
DB16688Reproxalap2Completed1
DB09029Secukinumab2Completed1
DB00877Sirolimus2Completed1
DB12441Tavilermide2Completed1
DB12003Thymosin beta-42Completed2
DB11693Voclosporin2Completed1
DB09321Zinc oxide2Completed1
DB09120Zucapsaicin2Completed1
DB11059Carboxymethylcellulose2 / 3Completed1
DB09462Glycerin2 / 3Completed1
DB00230Pregabalin2 / 3Completed1
DB16688Reproxalap2 / 3Recruiting1
DB00484Brimonidine3Completed1
DB00091Cyclosporine3Completed2
DB01234Dexamethasone3Completed1
DB01075Diphenhydramine3Completed2
DB15919Diquafosol3Completed1
DB00324Fluorometholone3Completed1
DB08818Hyaluronic acid3Completed1
DB08818Hyaluronic acid3Not Yet Recruiting1
DB08818Hyaluronic acid3Unknown Status1
DB01611Hydroxychloroquine3Completed1
DB11075Hypromellose3Not Yet Recruiting1
DB12373Isunakinra3Unknown Status1
DB11062Octisalate3Unknown Status1
DB09535Octocrylene3Unknown Status1
DB11133Omega-3 fatty acids3Completed1
DB01085Pilocarpine3Completed1
DB11077Polyethylene glycol 4003Completed2
DB01839Propylene glycol3Completed1
DB11078Propylene glycol3Completed1
DB11656Rebamipide3Completed1
DB16688Reproxalap3Completed1
DB00896Rimexolone3Completed1
DB09154Sodium citrate3Completed1
DB00864Tacrolimus3Completed1
DB12441Tavilermide3Completed1
DB12003Thymosin beta-43Active Not Recruiting1
DB11253Xanthan gum3Completed1
DB09321Zinc oxide3Unknown Status1
DB00207Azithromycin4Recruiting1
DB12792Boscalid4Completed1
DB09301Chondroitin sulfate4Not Yet Recruiting1
DB00091Cyclosporine4Completed5
DB00091Cyclosporine4Not Yet Recruiting3
DB00091Cyclosporine4Recruiting2
DB00091Cyclosporine4Terminated1
DB00091Cyclosporine4Unknown Status1
DB01234Dexamethasone4Recruiting3
DB01075Diphenhydramine4Completed1
DB01075Diphenhydramine4Unknown Status1
DB08818Hyaluronic acid4Completed1
DB08818Hyaluronic acid4Not Yet Recruiting2
DB11602Hydroxyethyl cellulose4Completed1
DB00840Hydroxypropyl cellulose4Unknown Status1
DB11075Hypromellose4Completed1
DB11611Lifitegrast4Completed1
DB11611Lifitegrast4Enrolling by Invitation1
DB11611Lifitegrast4Not Yet Recruiting1
DB11611Lifitegrast4Recruiting2
DB11611Lifitegrast4Withdrawn2
DB14596Loteprednol etabonate4Recruiting1
DB11228Methylcellulose4Completed1
DB11062Octisalate4Completed1
DB09535Octocrylene4Completed1
DB11077Polyethylene glycol 4004Completed9
DB11077Polyethylene glycol 4004Recruiting1
DB11077Polyethylene glycol 4004Unknown Status2
DB11060Polyvinyl alcohol4Completed1
DB11061Povidone4Completed2
DB01839Propylene glycol4Completed4
DB11078Propylene glycol4Completed7
DB01839Propylene glycol4Recruiting1
DB11078Propylene glycol4Unknown Status2
DB09153Sodium chloride4Completed1
DB09449Sodium phosphate, monobasic4Completed1
DB09321Zinc oxide4Completed1
DB12792BoscalidNot AvailableTerminated1
DB15649CarbomerNot AvailableCompleted1
DB15649CarbomerNot AvailableUnknown Status1
DB11059CarboxymethylcelluloseNot AvailableSuspended1
DB00091CyclosporineNot AvailableCompleted1
DB00091CyclosporineNot AvailableRecruiting1
DB00091CyclosporineNot AvailableTerminated1
DB09255DextranNot AvailableCompleted1
DB09255DextranNot AvailableUnknown Status1
DB15919DiquafosolNot AvailableCompleted2
DB09462GlycerinNot AvailableCompleted1
DB09462GlycerinNot AvailableUnknown Status1
DB08818Hyaluronic acidNot AvailableCompleted3
DB08818Hyaluronic acidNot AvailableEnrolling by Invitation1
DB08818Hyaluronic acidNot AvailableNot Yet Recruiting1
DB08818Hyaluronic acidNot AvailableRecruiting1
DB08818Hyaluronic acidNot AvailableUnknown Status1
DB11075HypromelloseNot AvailableCompleted1
DB11075HypromelloseNot AvailableUnknown Status1
DB11611LifitegrastNot AvailableCompleted1
DB14596Loteprednol etabonateNot AvailableCompleted1
DB14596Loteprednol etabonateNot AvailableUnknown Status1
DB11057Mineral oilNot AvailableTerminated1
DB11058PetrolatumNot AvailableTerminated1
DB11077Polyethylene glycol 400Not AvailableCompleted1
DB11077Polyethylene glycol 400Not AvailableNot Yet Recruiting1
DB11077Polyethylene glycol 400Not AvailableUnknown Status1
DB01839Propylene glycolNot AvailableCompleted1
DB11078Propylene glycolNot AvailableCompleted1
DB01839Propylene glycolNot AvailableNot Yet Recruiting1
DB11078Propylene glycolNot AvailableUnknown Status1
DB09153Sodium chlorideNot AvailableCompleted1