Dry Eyes

Also known as: Dry Eye Symptom / Xeropthalmia / Dry Eye Symptoms / Ocular Dryness / Eyes Dry / Dryness of eyes / Dry Eye / Xerophthalmia / Eye Dryness / Dryness of the eyes / Decreased lacrimation / Lacrimation decreased / Dryness of eye / Dry eyes (finding) / Dry eye NOS / Other ocular manifestations of vitamin A deficiency / Dry eye syndrome / Tear film insufficiency, unspecified / Tear film insufficiency (disorder) / Xerophthalmia (disorder) / Tearing decreased / Reduced lacrimal gland secretion / Lacrimation reduced / Reduced tear production / Vitamin A deficiency with xerophthalmia (disorder)

DrugDrug NameDrug Description
DB02579Acrylic AcidA drug used in combination with benzalkonium for eye disinfection and lubrication.
DB15649CarbomerNot Annotated
DB14091Carbomer homopolymer type CA medication in artificial tears for the treatment of dry eyes.
DB05384Carbopol 974PA polymer used as a lacrimal substitute to treat symptoms associated with dry eyes.
DB11059CarboxymethylcelluloseA compound used as an ophthalmic lubricant.
DB14357ChamomileChamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
DB00091CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB09255DextranA low molecular weight dextran used as an adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma, as well as the prophylaxis of venous thrombosis and pulmonary embolism during high-risk medical procedures.
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB08818Hyaluronic acidA glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.
DB11075HypromelloseAn ingredient used in a wide variety of medications, and is not an approved medication.
DB09287Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
DB11077Polyethylene glycol 400An ingredient used in a wide variety of medications, and is not an approved medication.
DB11063Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
DB11060Polyvinyl alcoholA compound used as an ophthalmic lubricant.
DB11061PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
DB01839Propylene glycolA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
DB06764TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.
DB03904UreaA keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.
DB09322Zinc sulfateA drug used to replenish low levels of zinc or prevent zinc deficiency, or to test for zinc deficiency.
DrugDrug NameTargetType
DB02579Acrylic AcidBeta-lactamase SHV-1target
DB11059CarboxymethylcelluloseSolute carrier family 2, facilitated glucose transporter member 1target
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineP-glycoprotein 1transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB09462GlycerinMaleylacetoacetate isomerasetarget
DB09462GlycerinAquaporin-7transporter
DB09462GlycerinAquaporin-9transporter
DB09462GlycerinGlycerol uptake facilitator proteintransporter
DB08818Hyaluronic acidCD44 antigentarget
DB08818Hyaluronic acidIntercellular adhesion molecule 1target
DB08818Hyaluronic acidHyaluronan mediated motility receptortarget
DB08818Hyaluronic acidNeurocan core proteintarget
DB08818Hyaluronic acidVersican core proteintarget
DB08818Hyaluronic acidComplement component 1 Q subcomponent-binding protein, mitochondrialtarget
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 1target
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 3target
DB08818Hyaluronic acidHyaluronan-binding protein 2target
DB08818Hyaluronic acidLayilintarget
DB08818Hyaluronic acidStabilin-2target
DB08818Hyaluronic acidTumor necrosis factor-inducible gene 6 proteintarget
DB08818Hyaluronic acidInterphotoreceptor matrix proteoglycan 2target
DB08818Hyaluronic acidIntracellular hyaluronan-binding protein 4target
DB08818Hyaluronic acidHyaluronidase enzymesenzyme
DB08818Hyaluronic acidMultidrug resistance-associated protein 5transporter
DB08818Hyaluronic acidLymphatic vessel endothelial hyaluronic acid receptor 1target
DB11075HypromelloseEpithelial cell adhesion moleculetarget
DB09287Polyethylene glycolP-glycoprotein 1transporter
DB11077Polyethylene glycol 400Oxidoreductase HTATIP2target
DB11077Polyethylene glycol 400Cytochrome P450 4A11enzyme
DB11077Polyethylene glycol 400Alcohol dehydrogenase class-3enzyme
DB11077Polyethylene glycol 400Sulfotransferase 1A1enzyme
DB11077Polyethylene glycol 400Ectonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB11077Polyethylene glycol 400P-glycoprotein 1transporter
DB01839Propylene glycolB12-independent glycerol dehydratasetarget
DB06764TetryzolineAlpha-1 adrenergic receptorstarget
DB06764TetryzolineAlpha-2 adrenergic receptorstarget
DB03904UreaArginase-1target
DB03904UreaCarbonic anhydrase 2target
DB03904UreaCatenin beta-1target
DB03904UreaSulfoxide reductase catalytic subunit YedYtarget
DB03904UreaUrea transporter 2transporter
DB03904UreaUrea transporter 1transporter
DB03904UreaDihydrofolate reductasetarget
DrugDrug NamePhaseStatusCount
DB13906Aloe vera leafNot AvailableRecruiting1
DB11059CarboxymethylcelluloseNot AvailableRecruiting1
DB14322Coconut oilNot AvailableRecruiting1
DB09462GlycerinNot AvailableRecruiting1
DB08818Hyaluronic acidNot AvailableRecruiting1
DB11063Polysorbate 80Not AvailableRecruiting1
DB01839Propylene glycolNot AvailableRecruiting1
DB14272RosemaryNot AvailableRecruiting1
DB01234Dexamethasone0Completed1
DB14596Loteprednol etabonate0Completed1
DB11061Povidone0Completed1
DB00877Sirolimus0Completed1
DB09145Water0Completed1
DB09145Water0Withdrawn1
DB13906Aloe vera leaf1Completed1
DB00126Ascorbic acid1Completed1
DB01234Dexamethasone1Completed1
DB09357Dexpanthenol1Completed1
DB09462Glycerin1Completed1
DB08818Hyaluronic acid1Completed1
DB00030Insulin human1Recruiting1
DB12373Isunakinra1Completed1
DB02701Nicotinamide1Completed1
DB11077Polyethylene glycol 4001Not Yet Recruiting1
DB01839Propylene glycol1Not Yet Recruiting1
DB19105Tivanisiran1Completed1
DB00684Tobramycin1Completed1
DB00162Vitamin A1Completed1
DB00484Brimonidine1 / 2Terminated1
DB18414CAM-1011 / 2Completed1
DB00003Dornase alfa1 / 2Terminated2
DB18921Lacripep1 / 2Completed1
DB01839Propylene glycol1 / 2Completed1
DB09145Water1 / 2Completed1
DB00945Acetylsalicylic acid2Completed1
DB13906Aloe vera leaf2Completed3
DB00126Ascorbic acid2Completed1
DB00484Brimonidine2Completed1
DB06168Canakinumab2Completed1
DB15649Carbomer2Recruiting1
DB11059Carboxymethylcellulose2Completed1
DB13926Cenegermin2Completed1
DB14322Coconut oil2Completed2
DB00091Cyclosporine2Completed2
DB01234Dexamethasone2Completed1
DB15919Diquafosol2Completed1
DB00254Doxycycline2Completed2
DB09462Glycerin2Completed1
DB08818Hyaluronic acid2Completed3
DB11075Hypromellose2Completed1
DB11075Hypromellose2Recruiting1
DB00465Ketorolac2Withdrawn1
DB01759Kojic acid2Completed1
DB18936Licaminlimab2Completed1
DB11611Lifitegrast2Completed2
DB14596Loteprednol etabonate2Completed1
DB11228Methylcellulose2Withdrawn1
DB11057Mineral oil2Completed1
DB02701Nicotinamide2Completed2
DB11058Petrolatum2Completed1
DB11077Polyethylene glycol 4002Completed2
DB01839Propylene glycol2Completed2
DB11078Propylene glycol2Completed2
DB11656Rebamipide2Completed1
DB16688Reproxalap2Completed3
DB14272Rosemary2Completed2
DB09029Secukinumab2Completed1
DB00877Sirolimus2Completed1
DB19142Tanfanercept2Completed1
DB12441Tavilermide2Completed1
DB12003Thymosin beta-42Completed2
DB00162Vitamin A2Completed2
DB11693Voclosporin2Completed1
DB09145Water2Completed3
DB09145Water2Withdrawn1
DB09120Zucapsaicin2Completed1
DB11059Carboxymethylcellulose2 / 3Completed1
DB09462Glycerin2 / 3Completed1
DB08818Hyaluronic acid2 / 3Completed1
DB00230Pregabalin2 / 3Completed1
DB16688Reproxalap2 / 3Completed1
DB13906Aloe vera leaf3Unknown Status1
DB00126Ascorbic acid3Unknown Status1
DB00484Brimonidine3Completed1
DB13926Cenegermin3Completed1
DB00091Cyclosporine3Completed2
DB00091Cyclosporine3Recruiting1
DB01234Dexamethasone3Completed1
DB01075Diphenhydramine3Completed2
DB15919Diquafosol3Completed1
DB15919Diquafosol3Recruiting1
DB00324Fluorometholone3Completed1
DB09462Glycerin3Unknown Status1
DB08818Hyaluronic acid3Completed2
DB08818Hyaluronic acid3Unknown Status1
DB01611Hydroxychloroquine3Completed1
DB11075Hypromellose3Completed1
DB12373Isunakinra3Unknown Status1
DB16956L-Acetylleucine3Completed1
DB14596Loteprednol etabonate3Completed1
DB02701Nicotinamide3Unknown Status1
DB11133Omega-3 fatty acids3Completed1
DB01085Pilocarpine3Completed1
DB19295Platelet Rich Plasma3Completed1
DB19295Platelet Rich Plasma3Not Yet Recruiting1
DB11077Polyethylene glycol 4003Completed2
DB01839Propylene glycol3Completed1
DB11078Propylene glycol3Completed1
DB11656Rebamipide3Completed1
DB16688Reproxalap3Completed2
DB00896Rimexolone3Completed1
DB09154Sodium citrate3Completed1
DB00864Tacrolimus3Completed1
DB19142Tanfanercept3Completed2
DB19142Tanfanercept3Suspended1
DB12441Tavilermide3Completed1
DB12003Thymosin beta-43Completed1
DB01273Varenicline3Recruiting1
DB00162Vitamin A3Unknown Status1
DB09145Water3Completed2
DB11253Xanthan gum3Completed1
DB13906Aloe vera leaf4Completed2
DB13906Aloe vera leaf4Not Yet Recruiting1
DB00126Ascorbic acid4Completed1
DB00126Ascorbic acid4Not Yet Recruiting1
DB00207Azithromycin4Recruiting1
DB01294Bismuth subsalicylate4Completed1
DB12792Boscalid4Completed1
DB11059Carboxymethylcellulose4Completed2
DB09301Chondroitin sulfate4Completed1
DB14322Coconut oil4Completed1
DB00091Cyclosporine4Completed9
DB00091Cyclosporine4Recruiting3
DB00091Cyclosporine4Terminated1
DB00091Cyclosporine4Unknown Status1
DB00091Cyclosporine4Withdrawn1
DB01234Dexamethasone4Completed2
DB01234Dexamethasone4Recruiting1
DB01234Dexamethasone4Terminated1
DB01075Diphenhydramine4Completed1
DB01075Diphenhydramine4Unknown Status1
DB09462Glycerin4Completed2
DB09462Glycerin4Not Yet Recruiting1
DB08818Hyaluronic acid4Completed3
DB00741Hydrocortisone4Recruiting1
DB11602Hydroxyethyl cellulose4Completed1
DB00840Hydroxypropyl cellulose4Unknown Status1
DB11075Hypromellose4Completed1
DB00030Insulin human4Recruiting2
DB11611Lifitegrast4Completed4
DB11611Lifitegrast4Recruiting1
DB11611Lifitegrast4Withdrawn3
DB14596Loteprednol etabonate4Completed1
DB11228Methylcellulose4Completed1
DB11057Mineral oil4Completed1
DB02701Nicotinamide4Completed1
DB02701Nicotinamide4Not Yet Recruiting1
DB17823Perfluorohexyloctane4Completed2
DB17823Perfluorohexyloctane4Recruiting1
DB11058Petrolatum4Completed1
DB11077Polyethylene glycol 4004Completed10
DB11077Polyethylene glycol 4004Recruiting1
DB11077Polyethylene glycol 4004Unknown Status2
DB11063Polysorbate 804Completed1
DB11060Polyvinyl alcohol4Completed1
DB11061Povidone4Completed2
DB01839Propylene glycol4Completed8
DB11078Propylene glycol4Completed7
DB01839Propylene glycol4Recruiting1
DB11078Propylene glycol4Unknown Status2
DB14272Rosemary4Completed1
DB09153Sodium chloride4Completed1
DB09449Sodium phosphate, monobasic4Completed1
DB12310Trehalose4Not Yet Recruiting1
DB01273Varenicline4Completed2
DB01273Varenicline4Terminated1
DB00162Vitamin A4Completed1
DB00162Vitamin A4Not Yet Recruiting1
DB09145Water4Completed2
DB09145Water4Unknown Status1
DB13906Aloe vera leafNot AvailableCompleted1
DB13906Aloe vera leafNot AvailableTerminated1
DB13906Aloe vera leafNot AvailableUnknown Status1
DB00126Ascorbic acidNot AvailableCompleted1
DB12792BoscalidNot AvailableTerminated1
DB15649CarbomerNot AvailableCompleted1
DB15649CarbomerNot AvailableUnknown Status1
DB11059CarboxymethylcelluloseNot AvailableCompleted1
DB14322Coconut oilNot AvailableTerminated1
DB14322Coconut oilNot AvailableUnknown Status1
DB00091CyclosporineNot AvailableActive Not Recruiting1
DB00091CyclosporineNot AvailableCompleted2
DB00091CyclosporineNot AvailableRecruiting1
DB00091CyclosporineNot AvailableTerminated1
DB09255DextranNot AvailableCompleted1
DB09255DextranNot AvailableUnknown Status1
DB15919DiquafosolNot AvailableCompleted3
DB15919DiquafosolNot AvailableNot Yet Recruiting1
DB15919DiquafosolNot AvailableRecruiting2
DB09462GlycerinNot AvailableCompleted2
DB09462GlycerinNot AvailableUnknown Status1
DB08818Hyaluronic acidNot AvailableCompleted5
DB08818Hyaluronic acidNot AvailableTerminated1
DB08818Hyaluronic acidNot AvailableUnknown Status3
DB11075HypromelloseNot AvailableCompleted1
DB11075HypromelloseNot AvailableUnknown Status1
DB00654LatanoprostNot AvailableCompleted1
DB11611LifitegrastNot AvailableCompleted1
DB14596Loteprednol etabonateNot AvailableCompleted1
DB14596Loteprednol etabonateNot AvailableUnknown Status1
DB11057Mineral oilNot AvailableTerminated1
DB02701NicotinamideNot AvailableCompleted1
DB11058PetrolatumNot AvailableTerminated1
DB11077Polyethylene glycol 400Not AvailableCompleted1
DB11077Polyethylene glycol 400Not AvailableUnknown Status1
DB01839Propylene glycolNot AvailableCompleted1
DB11078Propylene glycolNot AvailableCompleted1
DB01839Propylene glycolNot AvailableTerminated1
DB11078Propylene glycolNot AvailableUnknown Status1
DB14272RosemaryNot AvailableTerminated1
DB14272RosemaryNot AvailableUnknown Status1
DB09153Sodium chlorideNot AvailableCompleted1
DB00162Vitamin ANot AvailableCompleted1
DB09145WaterNot AvailableCompleted2