Lower Respiratory Tract Infection (LRTI)

Also known as: Lower respiratory tract infection NOS / Lower Tract Respiratory Infection / LRTI / Lower Respiratory Tract Infections / Lower Respiratory Tract Infection / Respiratory tract infection (& [acute lower] or [lower]) / Lower resp tract infec / Chest infection NOS (disorder) / Lower resp. tract infection / Acute lower respiratory tract infection / Chest infection / Chest infection (disorder) / Chest infection (& NOS) / Lower respiratory tract infection (disorder) / Infection of lower respiratory tract

DrugDrug NameDrug Description
DB01060AmoxicillinA penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
DB00355AztreonamA beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.
DB01602BacampicillinAn ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections.
DB01329CefoperazoneA broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts.
DB01416CefpodoximeA third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.
DB00438CeftazidimeAn injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.
DB01415CeftibutenA third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis.
DB01112CefuroximeA cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo.
DB00766Clavulanic acidA beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.
DB00954DirithromycinAn antibiotic used to treat a variety of respiratory, skin, and other infections.
DB00199ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
DB00417PhenoxymethylpenicillinA penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.
DB00319PiperacillinA penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.
DrugDrug NameTargetType
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB01060AmoxicillinCytochrome P450 2C8enzyme
DB01060AmoxicillinSerum albumincarrier
DB01060AmoxicillinBeta-lactamase 2enzyme
DB01060AmoxicillinPenicillin binding proteintarget
DB00355AztreonamPenicillin-binding protein 3target
DB00355AztreonamBeta-lactamasetarget
DB01602BacampicillinPenicillin-binding proteintarget
DB01329CefoperazoneSerum albumincarrier
DB01329CefoperazoneSolute carrier family 22 member 6transporter
DB01329CefoperazoneSolute carrier family 22 member 8transporter
DB01329CefoperazoneSolute carrier family 22 member 11transporter
DB01329CefoperazoneSolute carrier family 22 member 7transporter
DB01329CefoperazonePeptidoglycan synthase FtsItarget
DB01329CefoperazonePenicillin-binding protein 1Btarget
DB01329CefoperazonePenicillin-binding protein 2target
DB01329CefoperazonePenicillin-binding protein 1Atarget
DB01329CefoperazoneD-alanyl-D-alanine carboxypeptidase DacCtarget
DB01329CefoperazoneD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01329CefoperazoneD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01329CefoperazonePenicillin-binding protein 1Atarget
DB01329CefoperazonePenicillin-binding protein 1Btarget
DB01416CefpodoximePeptidoglycan synthase FtsItarget
DB00438CeftazidimeSolute carrier family 22 member 6transporter
DB00438CeftazidimePeptidoglycan synthase FtsItarget
DB00438CeftazidimePenicillin-binding protein 1Atarget
DB00438CeftazidimePenicillin-binding protein 1Btarget
DB00438CeftazidimePenicillin-binding protein 2target
DB00438CeftazidimeSerum albumincarrier
DB01415CeftibutenSolute carrier family 15 member 1transporter
DB01415CeftibutenSolute carrier family 15 member 2transporter
DB01415CeftibutenPeptidoglycan synthase FtsItarget
DB01415CeftibutenPenicillin-binding protein 1Atarget
DB01415CeftibutenPenicillin-binding protein 1Btarget
DB01415CeftibutenPenicillin-binding protein 2target
DB01415CeftibutenSolute carrier family 22 member 6transporter
DB01415CeftibutenSolute carrier family 22 member 8transporter
DB01112CefuroximePenicillin-binding protein 1Atarget
DB01112CefuroximeSolute carrier family 15 member 1transporter
DB01112CefuroximeSolute carrier family 15 member 2transporter
DB00766Clavulanic acidBacterial beta-lactamase enzymestarget
DB00766Clavulanic acidSodium/glucose cotransporter 1transporter
DB00954Dirithromycin23S ribosomal RNAtarget
DB00954DirithromycinCytochrome P450 3A4enzyme
DB00199Erythromycin23S ribosomal RNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinP-glycoprotein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DB00319PiperacillinSolute carrier family 22 member 6transporter
DB00319PiperacillinPenicillin-binding protein 3target
DB00319PiperacillinPenicillin-binding protein 2Btarget
DB00319PiperacillinPenicillin-binding protein 2atarget
DB00319PiperacillinPenicillin-binding protein 1btarget
DB00319PiperacillinSolute carrier family 22 member 8transporter
DrugDrug NamePhaseStatusCount
DB00003Dornase alfa2Completed1
DB15313DAS-1813Recruiting1
DB16258Nirsevimab3Not Yet Recruiting1
DB16533OM853Not Yet Recruiting1
DB00198Oseltamivir3Completed1
DB01060Amoxicillin4Recruiting1
DB00760Meropenem4Completed1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen4Completed1
DB10332Streptococcus pneumoniae type 14 capsular polysaccharide antigen4Completed1
DB10335Streptococcus pneumoniae type 18c capsular polysaccharide antigen4Completed1
DB10336Streptococcus pneumoniae type 19f capsular polysaccharide antigen4Completed1
DB10340Streptococcus pneumoniae type 23f capsular polysaccharide antigen4Completed1
DB10322Streptococcus pneumoniae type 4 capsular polysaccharide antigen4Completed1
DB10323Streptococcus pneumoniae type 5 capsular polysaccharide antigen4Completed1
DB10324Streptococcus pneumoniae type 6b capsular polysaccharide antigen4Completed1
DB10325Streptococcus pneumoniae type 7f capsular polysaccharide antigen4Completed1
DB10328Streptococcus pneumoniae type 9v capsular polysaccharide antigen4Completed1
DB00802AlfentanilNot AvailableCompleted1
DB00479AmikacinNot AvailableCompleted1
DB00513Aminocaproic acidNot AvailableCompleted1
DB00207AzithromycinNot AvailableTerminated1
DB00559BosentanNot AvailableCompleted1
DB01413CefepimeNot AvailableCompleted1
DB00369CidofovirNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableCompleted1
DB01211ClarithromycinNot AvailableCompleted1
DB00363ClozapineNot AvailableCompleted1
DB00828FosfomycinNot AvailableCompleted1
DB00502HaloperidolNot AvailableCompleted1
DB10773Influenza A virus A/California/7/2009 (H1N1) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB14417Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB14423Influenza A virus A/Michigan/45/2015 (H1N1) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB10774Influenza A virus A/Victoria/361/2011 (H3N2) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB14418Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigenNot AvailableRecruiting1
DB10779Influenza B virus B/Phuket/3073/2013 recombinant hemagglutinin antigenNot AvailableRecruiting1
DB10775Influenza B virus B/Wisconsin/1/2010 recombinant hemagglutinin antigenNot AvailableRecruiting1
DB00598LabetalolNot AvailableCompleted1
DB08815LurasidoneNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableCompleted1
DB01618MolindoneNot AvailableCompleted1
DB00607NafcillinNot AvailableCompleted1
DB01115NifedipineNot AvailableCompleted1
DB00497OxycodoneNot AvailableCompleted1
DB00312PentobarbitalNot AvailableCompleted1
DB00319PiperacillinNot AvailableCompleted1
DB00728RocuroniumNot AvailableCompleted1
DB00658SevelamerNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted1
DB01606TazobactamNot AvailableCompleted1
DB00684TobramycinNot AvailableCompleted1
DB00302Tranexamic acidNot AvailableCompleted1
DB00512VancomycinNot AvailableCompleted1
DB01339VecuroniumNot AvailableCompleted1
DB00682WarfarinNot AvailableCompleted1
DB00246ZiprasidoneNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted1