Unresectable Melanoma

Also known as: Melanoma Unresectable

DrugDrug NameDrug Description
DB11595AtezolizumabA monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
DB11967BinimetinibA medication used to treat metastatic melanoma with specific mutations.
DB05239CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
DB08912DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
DB11718EncorafenibA kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
DB06186IpilimumabA human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
DB17107LifileucelAn autologous T cell immunotherapy used to treat unresectable or metastatic melanoma in previously treated adults.
DB09035NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
DB09037PembrolizumabA PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
DB14851RelatlimabA monoclonal antibody targeted against LAG-3 which is used in combination with nivolumab for the treatment of unresectable or metastatic melanoma.
DB08911TrametinibA kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
DB08881VemurafenibA kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
DrugDrug NameTargetType
DB11595AtezolizumabProgrammed cell death 1 ligand 1target
DB11595AtezolizumabProgrammed cell death protein 1target
DB11967BinimetinibUDP-glucuronosyltransferase 1A1enzyme
DB11967BinimetinibCytochrome P450 1A2enzyme
DB11967BinimetinibCytochrome P450 2C19enzyme
DB11967BinimetinibDual specificity mitogen-activated protein kinase kinase 2target
DB11967BinimetinibAlbumincarrier
DB11967BinimetinibDual specificity mitogen-activated protein kinase kinase 1target
DB11967BinimetinibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB11967BinimetinibATP-dependent translocase ABCB1transporter
DB05239CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
DB05239CobimetinibCytochrome P450 3A4enzyme
DB05239CobimetinibSolute carrier organic anion transporter family member 1B1transporter
DB05239CobimetinibSolute carrier organic anion transporter family member 1B3transporter
DB05239CobimetinibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB05239CobimetinibATP-dependent translocase ABCB1transporter
DB05239CobimetinibUDP-glucuronosyltransferase 2B7enzyme
DB05239CobimetinibCytochrome P450 2D6enzyme
DB05239CobimetinibCytochrome P450 3A5enzyme
DB05239CobimetinibAlpha-1-acid glycoprotein 1carrier
DB08912DabrafenibCytochrome P450 3A4enzyme
DB08912DabrafenibCytochrome P450 2C8enzyme
DB08912DabrafenibATP-dependent translocase ABCB1transporter
DB08912DabrafenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB08912DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DB08912DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DB08912DabrafenibSolute carrier family 22 member 6transporter
DB08912DabrafenibOrganic anion transporter 3transporter
DB08912DabrafenibSerine/threonine-protein kinase B-raftarget
DB08912DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB08912DabrafenibSerine/threonine-protein kinase SIK1target
DB08912DabrafenibSerine/threonine-protein kinase Nek11target
DB08912DabrafenibLIM domain kinase 1target
DB08912DabrafenibCytochrome P450 2B6enzyme
DB08912DabrafenibCytochrome P450 2C9enzyme
DB08912DabrafenibCytochrome P450 2C19enzyme
DB08912DabrafenibCytochrome P450 1A2enzyme
DB08912DabrafenibAlbumincarrier
DB08912DabrafenibSolute carrier organic anion transporter family member 1A2transporter
DB08912DabrafenibSolute carrier family 22 member 2transporter
DB08912DabrafenibUDP-glucuronosyltransferase 1A1enzyme
DB11718EncorafenibCytochrome P450 3A4enzyme
DB11718EncorafenibCytochrome P450 2C19enzyme
DB11718EncorafenibCytochrome P450 2D6enzyme
DB11718EncorafenibSerine/threonine-protein kinase B-raftarget
DB11718EncorafenibG1/S-specific cyclin-D1target
DB11718EncorafenibUDP-glucuronosyltransferase 1A1enzyme
DB11718EncorafenibAlbumincarrier
DB11718EncorafenibCytochrome P450 1A2enzyme
DB11718EncorafenibCytochrome P450 2B6enzyme
DB11718EncorafenibCytochrome P450 2C8enzyme
DB11718EncorafenibCytochrome P450 2C9enzyme
DB11718EncorafenibCytochrome P450 3A5enzyme
DB11718EncorafenibCytochrome P450 3A7enzyme
DB11718EncorafenibATP-dependent translocase ABCB1transporter
DB11718EncorafenibSolute carrier family 22 member 2transporter
DB11718EncorafenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB11718EncorafenibSolute carrier family 22 member 6transporter
DB11718EncorafenibOrganic anion transporter 3transporter
DB11718EncorafenibSolute carrier organic anion transporter family member 1B1transporter
DB11718EncorafenibSolute carrier organic anion transporter family member 1B3transporter
DB11718EncorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB11718EncorafenibMitogen-activated protein kinase 8target
DB11718EncorafenibMitogen-activated protein kinase 9target
DB11718EncorafenibMitogen-activated protein kinase 10target
DB11718EncorafenibLIM domain kinase 1target
DB11718EncorafenibLIM domain kinase 2target
DB11718EncorafenibDual specificity mitogen-activated protein kinase kinase 4target
DB11718EncorafenibSerine/threonine-protein kinase 36target
DB06186IpilimumabCytotoxic T-lymphocyte protein 4target
DB09035NivolumabProgrammed cell death protein 1target
DB09035NivolumabProgrammed cell death 1 ligand 1target
DB09037PembrolizumabProgrammed cell death protein 1target
DB09037PembrolizumabProgrammed cell death 1 ligand 1target
DB14851RelatlimabLymphocyte activation gene 3 proteintarget
DB08911TrametinibCytochrome P450 2C8enzyme
DB08911TrametinibCytochrome P450 3A4enzyme
DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 1target
DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 2target
DB08881VemurafenibAlbumincarrier
DB08881VemurafenibAlpha-1-acid glycoprotein 1carrier
DB08881VemurafenibCytochrome P450 1A2enzyme
DB08881VemurafenibCytochrome P450 2D6enzyme
DB08881VemurafenibCytochrome P450 3A4enzyme
DB08881VemurafenibSerine/threonine-protein kinase B-raftarget
DB08881VemurafenibMultidrug resistance-associated protein 1transporter
DB08881VemurafenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB08881VemurafenibCytochrome P450 2C9enzyme
DB08881VemurafenibCytochrome P450 2C8enzyme
DB08881VemurafenibCytochrome P450 2B6enzyme
DB08881VemurafenibATP-dependent translocase ABCB1transporter
DrugDrug NamePhaseStatusCount
DB17107LifileucelNot AvailableAvailable1
DB00062Albumin human1Completed1
DB00041Aldesleukin1Not Yet Recruiting1
DB00112Bevacizumab1Completed1
DB11967Binimetinib1Completed1
DB11967Binimetinib1Unknown Status1
DB11967Binimetinib1Withdrawn1
DB19293CDX-3011Recruiting1
DB01373Calcium1Active Not Recruiting1
DB04690Camptothecin1Active Not Recruiting1
DB01101Capecitabine1Active Not Recruiting1
DB00958Carboplatin1Active Not Recruiting1
DB11059Carboxymethylcellulose1Recruiting1
DB09063Ceritinib1Active Not Recruiting1
DB14681Cortisone1Active Not Recruiting1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Not Yet Recruiting1
DB00531Cyclophosphamide1Recruiting1
DB19064Danburstotug1Recruiting1
DB00694Daunorubicin1Active Not Recruiting1
DB00997Doxorubicin1Active Not Recruiting1
DB11718Encorafenib1Withdrawn1
DB08871Eribulin1Active Not Recruiting1
DB01175Escitalopram1Active Not Recruiting1
DB01073Fludarabine1Not Yet Recruiting1
DB01073Fludarabine1Recruiting1
DB00544Fluorouracil1Active Not Recruiting1
DB17293Hiltonol1Recruiting1
DB14999Human interferon beta1Active Not Recruiting1
DB14865Human interleukin-21Recruiting1
DB09053Ibrutinib1Active Not Recruiting1
DB00619Imatinib1Completed1
DB06186Ipilimumab1Active Not Recruiting3
DB06186Ipilimumab1Completed2
DB00762Irinotecan1Active Not Recruiting1
DB00650Leucovorin1Active Not Recruiting1
DB11596Levoleucovorin1Active Not Recruiting1
DB00123Lysine1Recruiting1
DB09035Nivolumab1Active Not Recruiting3
DB09035Nivolumab1Withdrawn1
DB09074Olaparib1Active Not Recruiting1
DB00526Oxaliplatin1Active Not Recruiting1
DB01229Paclitaxel1Active Not Recruiting1
DB01229Paclitaxel1Completed1
DB01229Paclitaxel1Recruiting1
DB09037Pembrolizumab1Active Not Recruiting2
DB09037Pembrolizumab1Completed1
DB09037Pembrolizumab1Recruiting2
DB00642Pemetrexed1Active Not Recruiting1
DB00635Prednisone1Active Not Recruiting1
DB00020Sargramostim1Withdrawn1
DB11942Selinexor1Active Not Recruiting1
DB09143Sonidegib1Recruiting1
DB00864Tacrolimus1Active Not Recruiting1
DB06273Tocilizumab1Recruiting1
DB01030Topotecan1Active Not Recruiting1
DB08911Trametinib1Active Not Recruiting1
DB16626Tyrosinase1Active Not Recruiting1
DB06626Axitinib1 / 2Active Not Recruiting1
DB14681Cortisone1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB08912Dabrafenib1 / 2Active Not Recruiting2
DB01262Decitabine1 / 2Active Not Recruiting1
DB11952Duvelisib1 / 2Active Not Recruiting1
DB06186Ipilimumab1 / 2Completed1
DB06186Ipilimumab1 / 2Recruiting1
DB17107Lifileucel1 / 2Active Not Recruiting1
DB15994Methane1 / 2Active Not Recruiting1
DB12340Navitoclax1 / 2Active Not Recruiting1
DB09035Nivolumab1 / 2Active Not Recruiting1
DB09035Nivolumab1 / 2Completed1
DB09035Nivolumab1 / 2Recruiting1
DB09035Nivolumab1 / 2Unknown Status1
DB09037Pembrolizumab1 / 2Recruiting1
DB00635Prednisone1 / 2Recruiting1
DB00020Sargramostim1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting1
DB08911Trametinib1 / 2Active Not Recruiting2
DB11969Uprosertib1 / 2Active Not Recruiting1
DB00062Albumin human2Completed1
DB06626Axitinib2Active Not Recruiting1
DB18177BNT1112Active Not Recruiting1
DB00112Bevacizumab2Active Not Recruiting1
DB00112Bevacizumab2Completed1
DB11967Binimetinib2Active Not Recruiting1
DB14707Cemiplimab2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting1
DB08912Dabrafenib2Active Not Recruiting2
DB08912Dabrafenib2Completed1
DB08912Dabrafenib2Terminated1
DB11718Encorafenib2Active Not Recruiting1
DB01073Fludarabine2Recruiting1
DB14865Human interleukin-22Recruiting1
DB06205Hyaluronidase (human recombinant)2Active Not Recruiting1
DB01611Hydroxychloroquine2Terminated1
DB06186Ipilimumab2Active Not Recruiting5
DB06186Ipilimumab2Completed2
DB06186Ipilimumab2Recruiting2
DB17107Lifileucel2Recruiting1
DB15994Methane2Active Not Recruiting1
DB09035Nivolumab2Active Not Recruiting5
DB09035Nivolumab2Completed1
DB09035Nivolumab2Recruiting2
DB09035Nivolumab2Terminated1
DB01229Paclitaxel2Completed2
DB06589Pazopanib2Completed1
DB09037Pembrolizumab2Active Not Recruiting1
DB09037Pembrolizumab2Recruiting1
DB09037Pembrolizumab2Suspended1
DB09037Pembrolizumab2Withdrawn1
DB14851Relatlimab2Recruiting1
DB15766Retifanlimab2Completed1
DB12146Rigosertib2Suspended1
DB00073Rituximab2Active Not Recruiting1
DB00020Sargramostim2Active Not Recruiting1
DB00020Sargramostim2Withdrawn1
DB11767Sarilumab2Recruiting1
DB16413Sotigalimab2Terminated1
DB13896Talimogene laherparepvec2Active Not Recruiting1
DB15389Teceleukin2Recruiting1
DB06273Tocilizumab2Active Not Recruiting1
DB08911Trametinib2Active Not Recruiting2
DB08911Trametinib2Completed1
DB08911Trametinib2Terminated1
DB17500Vidutolimod2Terminated1
DB00851Dacarbazine2 / 3Not Yet Recruiting1
DB06186Ipilimumab2 / 3Not Yet Recruiting1
DB18091LNS-88012 / 3Not Yet Recruiting1
DB09035Nivolumab2 / 3Not Yet Recruiting1
DB09035Nivolumab2 / 3Terminated1
DB09037Pembrolizumab2 / 3Not Yet Recruiting1
DB14851Relatlimab2 / 3Not Yet Recruiting1
DB00853Temozolomide2 / 3Not Yet Recruiting1
DB17500Vidutolimod2 / 3Terminated1
DB08912Dabrafenib3Active Not Recruiting1
DB00851Dacarbazine3Active Not Recruiting1
DB06186Ipilimumab3Active Not Recruiting1
DB17107Lifileucel3Recruiting1
DB15994Methane3Active Not Recruiting1
DB09035Nivolumab3Active Not Recruiting1
DB18946Nurulimab3Recruiting1
DB09037Pembrolizumab3Active Not Recruiting1
DB09037Pembrolizumab3Recruiting1
DB16740Prolgolimab3Recruiting1
DB15043Toripalimab3Active Not Recruiting1
DB08911Trametinib3Active Not Recruiting1