Unresectable Melanoma

DrugDrug NameDrug Description
DB11595AtezolizumabA monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
DB11967BinimetinibA medication used to treat metastatic melanoma with specific mutations.
DB05239CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
DB08912DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
DB11718EncorafenibA kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
DB06186IpilimumabA human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
DB09035NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
DB09037PembrolizumabA PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
DB14851RelatlimabA monoclonal antibody targeted against LAG-3 which is used in combination with nivolumab for the treatment of unresectable or metastatic melanoma.
DB08911TrametinibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
DB08881VemurafenibA kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
DrugDrug NameTargetType
DB11595AtezolizumabProgrammed cell death 1 ligand 1target
DB11967BinimetinibInterleukin-6target
DB11967BinimetinibTumor necrosis factortarget
DB11967BinimetinibInterleukin-1 betatarget
DB11967BinimetinibUDP-glucuronosyltransferase 1-1enzyme
DB11967BinimetinibCytochrome P450 1A2enzyme
DB11967BinimetinibCytochrome P450 2C19enzyme
DB11967BinimetinibMitogen-activated protein kinase kinase kinase 1target
DB11967BinimetinibDual specificity mitogen-activated protein kinase kinase 2target
DB05239CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
DB05239CobimetinibCytochrome P450 3A4enzyme
DB05239CobimetinibP-glycoprotein 1enzyme
DB05239CobimetinibSolute carrier organic anion transporter family member 1B1transporter
DB05239CobimetinibSolute carrier organic anion transporter family member 1B3transporter
DB05239CobimetinibATP-binding cassette sub-family G member 2transporter
DB05239CobimetinibP-glycoprotein 1transporter
DB08912DabrafenibCytochrome P450 3A4enzyme
DB08912DabrafenibCytochrome P450 2C8enzyme
DB08912DabrafenibP-glycoprotein 1transporter
DB08912DabrafenibATP-binding cassette sub-family G member 2transporter
DB08912DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DB08912DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DB08912DabrafenibSolute carrier family 22 member 6transporter
DB08912DabrafenibSolute carrier family 22 member 8transporter
DB08912DabrafenibSerine/threonine-protein kinase B-raftarget
DB08912DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB08912DabrafenibSerine/threonine-protein kinase SIK1target
DB08912DabrafenibSerine/threonine-protein kinase Nek11target
DB08912DabrafenibLIM domain kinase 1target
DB08912DabrafenibCytochrome P450 2B6enzyme
DB08912DabrafenibCytochrome P450 2C9enzyme
DB08912DabrafenibCytochrome P450 2C19enzyme
DB08912DabrafenibCytochrome P450 1A2enzyme
DB08912DabrafenibSerum albumincarrier
DB08912DabrafenibSolute carrier organic anion transporter family member 1A2transporter
DB08912DabrafenibSolute carrier family 22 member 2transporter
DB08912DabrafenibUDP-glucuronosyltransferase 1-1enzyme
DB11718EncorafenibCytochrome P450 3A4enzyme
DB11718EncorafenibCytochrome P450 2C19enzyme
DB11718EncorafenibCytochrome P450 2D6enzyme
DB11718EncorafenibSerine/threonine-protein kinase B-raftarget
DB11718EncorafenibG1/S-specific cyclin-D1target
DB06186IpilimumabCytotoxic T-lymphocyte protein 4target
DB09035NivolumabProgrammed cell death protein 1target
DB09037PembrolizumabProgrammed cell death protein 1target
DB14851RelatlimabLymphocyte activation gene 3 proteintarget
DB08911TrametinibCytochrome P450 2C8enzyme
DB08911TrametinibCytochrome P450 3A4enzyme
DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 1target
DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 2target
DB08881VemurafenibSerum albumincarrier
DB08881VemurafenibAlpha-1-acid glycoprotein 1carrier
DB08881VemurafenibCytochrome P450 1A2enzyme
DB08881VemurafenibCytochrome P450 2D6enzyme
DB08881VemurafenibCytochrome P450 3A4enzyme
DB08881VemurafenibSerine/threonine-protein kinase B-raftarget
DB08881VemurafenibMultidrug resistance-associated protein 1transporter
DB08881VemurafenibATP-binding cassette sub-family G member 2transporter
DB08881VemurafenibCytochrome P450 2C9enzyme
DB08881VemurafenibCytochrome P450 2C8enzyme
DB08881VemurafenibCytochrome P450 2B6enzyme
DB08881VemurafenibP-glycoprotein 1transporter
DrugDrug NamePhaseStatusCount
DB00062Albumin human1Recruiting1
DB00112Bevacizumab1Recruiting1
DB11967Binimetinib1Active Not Recruiting1
DB11967Binimetinib1Not Yet Recruiting1
DB01373Calcium1Recruiting1
DB04690Camptothecin1Recruiting1
DB01101Capecitabine1Recruiting1
DB00958Carboplatin1Recruiting1
DB09063Ceritinib1Active Not Recruiting1
DB00531Cyclophosphamide1Recruiting2
DB00694Daunorubicin1Recruiting1
DB00997Doxorubicin1Recruiting1
DB11718Encorafenib1Not Yet Recruiting1
DB08871Eribulin1Recruiting1
DB00544Fluorouracil1Recruiting1
DB14999Human interferon beta1Suspended1
DB09053Ibrutinib1Recruiting1
DB00619Imatinib1Recruiting1
DB06186Ipilimumab1Completed1
DB06186Ipilimumab1Recruiting3
DB06186Ipilimumab1Suspended1
DB00762Irinotecan1Recruiting1
DB00650Leucovorin1Recruiting1
DB11596Levoleucovorin1Recruiting1
DB09035Nivolumab1Recruiting2
DB09035Nivolumab1Suspended1
DB09074Olaparib1Recruiting1
DB00526Oxaliplatin1Recruiting1
DB01229Paclitaxel1Recruiting2
DB09037Pembrolizumab1Recruiting5
DB00642Pemetrexed1Recruiting1
DB00635Prednisone1Suspended1
DB00020Sargramostim1Recruiting1
DB11942Selinexor1Recruiting1
DB09143Sonidegib1Recruiting1
DB00864Tacrolimus1Suspended1
DB01030Topotecan1Recruiting1
DB08911Trametinib1Active Not Recruiting1
DB16626Tyrosinase1Suspended1
DB06626Axitinib1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB08912Dabrafenib1 / 2Active Not Recruiting2
DB01262Decitabine1 / 2Active Not Recruiting1
DB11952Duvelisib1 / 2Recruiting1
DB06186Ipilimumab1 / 2Active Not Recruiting1
DB15994Methane1 / 2Active Not Recruiting1
DB12340Navitoclax1 / 2Active Not Recruiting1
DB09035Nivolumab1 / 2Active Not Recruiting1
DB09035Nivolumab1 / 2Recruiting2
DB08911Trametinib1 / 2Active Not Recruiting2
DB11969Uprosertib1 / 2Active Not Recruiting1
DB00062Albumin human2Completed1
DB06626Axitinib2Recruiting1
DB00112Bevacizumab2Active Not Recruiting1
DB00112Bevacizumab2Completed1
DB11967Binimetinib2Recruiting1
DB14707Cemiplimab2Recruiting1
DB08912Dabrafenib2Active Not Recruiting2
DB08912Dabrafenib2Completed1
DB08912Dabrafenib2Recruiting1
DB11718Encorafenib2Recruiting1
DB06205Hyaluronidase (human recombinant)2Recruiting1
DB01611Hydroxychloroquine2Active Not Recruiting1
DB06186Ipilimumab2Active Not Recruiting3
DB06186Ipilimumab2Completed2
DB06186Ipilimumab2Recruiting3
DB15994Methane2Active Not Recruiting1
DB09035Nivolumab2Active Not Recruiting1
DB09035Nivolumab2Completed1
DB09035Nivolumab2Recruiting6
DB01229Paclitaxel2Completed2
DB06589Pazopanib2Completed1
DB09037Pembrolizumab2Active Not Recruiting1
DB09037Pembrolizumab2Recruiting2
DB15766Retifanlimab2Active Not Recruiting1
DB00073Rituximab2Recruiting1
DB00020Sargramostim2Active Not Recruiting1
DB00020Sargramostim2Recruiting1
DB16413Sotigalimab2Active Not Recruiting1
DB13896Talimogene laherparepvec2Active Not Recruiting1
DB06273Tocilizumab2Recruiting1
DB08911Trametinib2Active Not Recruiting2
DB08911Trametinib2Completed1
DB08911Trametinib2Recruiting1
DB09035Nivolumab2 / 3Recruiting1
DB00851Dacarbazine3Recruiting1
DB09037Pembrolizumab3Recruiting1
DB15043Toripalimab3Recruiting1