Sulfotransferase 1C2
Details
- Name
- Sulfotransferase 1C2
- Synonyms
- 2.8.2.-
- humSULTC2
- ST1C2
- Sulfotransferase 1C1
- SULT1C#1
- SULT1C1
- Gene Name
- SULT1C2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052134|Sulfotransferase 1C2 MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVD MIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFW ENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGW WEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTN RSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL
- Number of residues
- 296
- Molecular Weight
- 34879.905
- Theoretical pI
- Not Available
- GO Classification
- Functionssulfotransferase activityProcesses3'-phosphoadenosine 5'-phosphosulfate metabolic process / amine metabolic process / sulfationComponentscytoplasm / cytosol
- General Function
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
- Specific Function
- Sulfotransferase activity
- Pfam Domain Function
- Sulfotransfer_1 (PF00685)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052135|Sulfotransferase 1C2 (SULT1C2) ATGGCCCTGACCTCAGACCTGGGGAAACAGATAAAACTGAAAGAGGTGGAGGGGACCCTC CTGCAGCCTGCAACTGTGGACAACTGGAGCCAGATCCAGAGCTTCGAGGCCAAACCAGAT GATCTCCTCATCTGCACCTACCCTAAAGCAGGGACAACGTGGATTCAGGAAATTGTGGAT ATGATTGAACAGAATGGGGACGTGGAGAAGTGCCAGCGAGCCATCATCCAACACCGCCAT CCTTTCATTGAGTGGGCTCGGCCACCCCAACCTTCTGGTGTGGAAAAAGCCAAAGCAATG CCCTCTCCACGGATACTAAAGACTCACCTTTCCACTCAGCTGCTGCCACCGTCTTTCTGG GAAAACAACTGCAAGTTCCTTTATGTAGCTCGAAATGCCAAAGACTGTATGGTTTCCTAC TACCATTTCCAAAGGATGAACCACATGCTTCCTGACCCTGGTACCTGGGAAGAGTATTTT GAAACCTTCATCAATGGAAAAGTGGTTTGGGGTTCCTGGTTTGACCACGTGAAAGGATGG TGGGAGATGAAAGACAGACACCAGATTCTCTTCCTCTTCTATGAGGACATAAAGAGGGAC CCAAAGCATGAAATTCGGAAGGTGATGCAGTTCATGGGAAAGAAGGTGGATGAAACAGTG CTAGATAAAATTGTCCAGGAGACGTCATTTGAGAAAATGAAAGAAAATCCCATGACAAAT CGTTCTACAGTTTCCAAATCTATCTTGGACCAGTCAATTTCCTCCTTCATGAGAAAAGGA ACTGTGGGGGATTGGAAAAACCACTTCACTGTTGCCCAGAATGAGAGGTTTGATGAAATC TATAGAAGAAAGATGGAAGGAACCTCCATAAACTTCTGCATGGAACTCTGA
- Chromosome Location
- 2
- Locus
- 2q12.3
- External Identifiers
Resource Link UniProtKB ID O00338 UniProtKB Entry Name ST1C2_HUMAN HGNC ID HGNC:11456 - General References
- Her C, Kaur GP, Athwal RS, Weinshilboum RM: Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. Genomics. 1997 May 1;41(3):467-70. doi: 10.1006/geno.1997.4683. [Article]
- Yoshinari K, Nagata K, Shimada M, Yamazoe Y: Molecular characterization of ST1C1-related human sulfotransferase. Carcinogenesis. 1998 May;19(5):951-3. doi: 10.1093/carcin/19.5.951. [Article]
- Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC: Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene. J Biol Chem. 1998 Dec 18;273(51):33929-35. doi: 10.1074/jbc.273.51.33929. [Article]
- Hehonah N, Zhu X, Brix L, Bolton-Grob R, Barnett A, Windmill K, McManus M: Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase. Int J Biochem Cell Biol. 1999 Aug;31(8):869-82. doi: 10.1016/s1357-2725(99)00038-2. [Article]
- Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM: Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. Genomics. 2000 Apr 15;65(2):157-65. doi: 10.1006/geno.2000.6150. [Article]
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- Dombrovski L, Dong A, Bochkarev A, Plotnikov AN: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). Proteins. 2006 Sep 1;64(4):1091-4. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB09100 Thyroid, porcine approved unknown substrate Details DB00871 Terbutaline approved unknown substrate Details DB00960 Pindolol approved, investigational unknown substrate Details DB00968 Methyldopa approved no substrate Details DB12471 Ibrexafungerp approved, investigational unknown substrate Details DB00867 Ritodrine approved, investigational no substrate Details DB12243 Edaravone approved, investigational no substrate Details