Retinol-binding protein 1
Details
- Name
- Retinol-binding protein 1
- Synonyms
- Cellular retinol-binding protein
- Cellular retinol-binding protein I
- CRBP
- CRBP-I
- CRBP1
- Gene Name
- RBP1
- UniProtKB Entry
- P09455Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0036987|Retinol-binding protein 1 MPVDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRN YIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEM RVEGVVCKQVFKKVQ
- Number of residues
- 135
- Molecular Weight
- 15850.13
- Theoretical pI
- 4.74
- GO Classification
- Functionsall-trans-retinol binding / fatty acid bindingProcessesfatty acid transport / lipid homeostasisComponentslipid droplet / nucleus
- General Function
- Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496)
- Specific Function
- all-trans-retinol binding
- Pfam Domain Function
- Lipocalin (PF00061)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010070|Retinol-binding protein 1 (RBP1) ATGGATCCTCCCGCAGGCTTTGTGCGCGCTGGGAATCCAGCTGTCGCCGCCCCGCAGAGC CCCCTGTCCCCGGAGGGCGCTCATTTCCGGGCCGCCCACCACCCGCGTAGCACCGGCAGC CGCTGTCCCGGCAGTCTCCAGCCGTCCCGCCCGCTTGTGGCCAACTGGCTCCAGTCACTC CCCGAAATGCCAGTCGACTTCACTGGGTACTGGAAGATGTTGGTCAACGAGAATTTCGAG GAGTACCTGCGCGCCCTCGACGTCAATGTGGCCTTGCGCAAAATCGCCAACTTGCTGAAG CCAGACAAAGAGATCGTGCAGGACGGTGACCATATGATCATCCGCACGCTGAGCACTTTT AGGAACTACATCATGGACTTCCAGGTTGGGAAGGAGTTTGAGGAGGATCTGACAGGCATA GATGACCGCAAGTGCATGGCTGGAGTGCAATCGCGTGATCTCAGCTCACTGTAA
- Chromosome Location
- 3
- Locus
- 3q23
- External Identifiers
Resource Link UniProtKB ID P09455 UniProtKB Entry Name RET1_HUMAN GenBank Protein ID 190948 GenBank Gene ID M11433 GeneCard ID RBP1 GenAtlas ID RBP1 HGNC ID HGNC:9919 PDB ID(s) 5H8T, 5H9A, 5HA1, 5HBS, 5LJB, 5LJC, 5LJD, 5LJE, 5LJG, 5LJH, 5LJK, 6E5L, 6E5T, 6E6M, 8GD2, 8GDM, 8GEM, 8GEU, 8GEV, 8GEY KEGG ID hsa:5947 NCBI Gene ID 5947 - General References
- Colantuoni V, Cortese R, Nilsson M, Lundvall J, Bavik CO, Eriksson U, Peterson PA, Sundelin J: Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. Biochem Biophys Res Commun. 1985 Jul 16;130(1):431-9. [Article]
- Nilsson MH, Spurr NK, Lundvall J, Rask L, Peterson PA: Human cellular retinol-binding protein gene organization and chromosomal location. Eur J Biochem. 1988 Apr 5;173(1):35-44. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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- Wei LN, Mertz JR, Goodman DS, Nguyen-Huu MC: Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression. Mol Endocrinol. 1987 Aug;1(8):526-34. [Article]
- Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R: Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3710-5. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Retinol-binding protein 1 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Acitretin approved unknown target agonist Details Beta carotene approved, nutraceutical no carrier substrate Details Vitamin A approved, nutraceutical, vet_approved unknown carrier binder Details