Siroheme synthase
Details
- Name
- Siroheme synthase
- Synonyms
- 2.1.1.107
- Urogen III methylase
- Gene Name
- cysG
- UniProtKB Entry
- P25924Swiss-Prot
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- NCBI Taxonomy ID
- 99287
- Amino acid sequence
>lcl|BSEQ0019295|Siroheme synthase MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFTVWANEGMLTL VEGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFCNVVDAPKAASFIMPSIIDRS PLMVAVSSGGTSPVLARLLREKLESLLPQHLGQVARYAGQLRARVKKQFATMGERRRFWE KFFVNDRLAQSLANADEKAVNATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQ QADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLK GGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHL KTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVH GVLTQLGELAQQVESPALIIVGRVVALRDKLNWFSNH
- Number of residues
- 457
- Molecular Weight
- 50146.22
- Theoretical pI
- 6.79
- GO Classification
- FunctionsNAD binding / precorrin-2 dehydrogenase activity / sirohydrochlorin ferrochelatase activity / uroporphyrin-III C-methyltransferase activityProcessescobalamin biosynthetic process / siroheme biosynthetic process
- General Function
- Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
- Specific Function
- NAD binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019296|Siroheme synthase (cysG) GTGGACCATTTGCCTATATTTTGTCAATTACGCGACCGCGACTGTCTGATCGTCGGCGGT GGCGATGTCGCAGAACGCAAAGCACGGTTACTGCTGGAAGCAGGCGCACGTTTAACGGTC AATGCGCTAACCTTTATTCCACAGTTCACCGTATGGGCAAATGAAGGCATGTTGACTCTG GTTGAGGGACCGTTCGACGAAACGCTTCTCGACTCGTGTTGGCTGGCGATCGCGGCCACT GACGACGATACCGTCAACCAGCGCGTCAGCGACGCGGCGGAGTCACGCCGTATCTTTTGC AACGTGGTGGATGCGCCGAAAGCCGCCAGCTTTATCATGCCCTCCATTATTGACCGCTCG CCGCTGATGGTCGCCGTCTCCTCGGGCGGCACCTCCCCGGTGCTGGCGCGTCTGCTGCGC GAGAAACTGGAATCGCTGCTGCCGCAGCATCTGGGGCAGGTCGCGCGCTATGCCGGGCAA CTCCGCGCCCGAGTGAAAAAGCAGTTTGCCACGATGGGCGAGCGTCGTCGCTTCTGGGAA AAATTTTTCGTCAATGACCGGCTGGCGCAGTCGCTGGCGAATGCCGATGAGAAAGCGGTT AACGCGACAACCGAACGCCTGTTTAGCGAACCGCTGGATCACCGTGGCGAAGTCGTGCTG GTCGGCGCCGGGCCGGGCGATGCCGGACTGCTGACGCTGAAAGGGTTACAACAAATCCAA CAGGCGGATATCGTGGTTTACGATCGCCTCGTCTCCGACGACATTATGAACCTGGTACGC CGCGATGCCGATCGGGTCTTTGTGGGGAAACGCGCGGGTTACCACTGCGTCCCACAGGAG GAAATCAACCAGATCCTGCTGCGTGAAGCGCAAAAAGGTAAACGCGTGGTACGCCTGAAA GGCGGCGATCCCTTTATCTTTGGTCGCGGCGGCGAAGAGCTGGAAACGCTGTGTCATGCC GGTATTCCTTTCTCGGTAGTGCCGGGGATTACCGCGGCTTCCGGCTGCTCCGCCTACTCC GGTATTCCGCTAACTCATCGCGATTACGCCCAGAGCGTACGTCTGGTCACGGGTCACCTG AAAACCGGCGGCGAGCTGGACTGGGAAAACCTGGCGGCAGAAAAACAGACGCTGGTGTTC TACATGGGGCTGAATCAGGCAGCGACTATCCAGGAAAAACTGATCGCATTCGGTATGCAG GCCGATATGCCGGTTGCGCTGGTAGAAAACGGTACCTCCGTGAAGCAACGCGTCGTCCAC GGTGTGCTGACGCAGCTCGGTGAATTAGCGCAACAGGTTGAAAGCCCGGCGCTGATTATC GTTGGTCGCGTGGTAGCCTTACGCGATAAATTAAATTGGTTCTCTAATCATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25924 UniProtKB Entry Name CYSG_SALTY GenBank Gene ID M64606 PDB ID(s) 1PJQ, 1PJS, 1PJT KEGG ID stm:STM3477 NCBI Gene ID 1255000 - General References
- Wu JY, Siegel LM, Kredich NM: High-level expression of Escherichia coli NADPH-sulfite reductase: requirement for a cloned cysG plasmid to overcome limiting siroheme cofactor. J Bacteriol. 1991 Jan;173(1):325-33. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Stroupe ME, Leech HK, Daniels DS, Warren MJ, Getzoff ED: CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. Nat Struct Biol. 2003 Dec;10(12):1064-73. Epub 2003 Nov 2. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Siroheme synthase (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details S-adenosyl-L-homocysteine experimental unknown target Details Dexfosfoserine experimental unknown target Details