1,3-beta-glucan synthase component GSC2
Details
- Name
- 1,3-beta-glucan synthase component GSC2
- Synonyms
- 1,3-beta-D-glucan-UDP glucosyltransferase
- 2.4.1.34
- FK506 sensitivity protein 2
- FKS2
- GLS2
- Glucan synthase of cerevisiae protein 2
- Gene Name
- GSC2
- UniProtKB Entry
- P40989Swiss-Prot
- Organism
- Baker's yeast
- NCBI Taxonomy ID
- 559292
- Amino acid sequence
>lcl|BSEQ0052581|1,3-beta-glucan synthase component GSC2 MSYNDPNLNGQYYSNGDGTGDGNYPTYQVTQDQSAYDEYGQPIYTQNQLDDGYYDPNEQY VDGTQFPQGQDPSQDQGPYNNDASYYNQPPNMMNPSSQDGENFSDFSSYGPPSGTYPNDQ YTPSQMSYPDQDGSSGASTPYGNGVVNGNGQYYDPNAIEMALPNDPYPAWTADPQSPLPI EQIEDIFIDLTNKFGFQRDSMRNMFDHFMTLLDSRSSRMSPEQALLSLHADYIGGDTANY KKWYFAAQLDMDDEIGFRNMKLGKLSRKARKAKKKNKKAMQEASPEDTEETLNQIEGDNS LEAADFRWKSKMNQLSPFEMVRQIALFLLCWGEANQVRFTPECLCFIYKCASDYLDSAQC QQRPDPLPEGDFLNRVITPLYRFIRSQVYEIVDGRYVKSEKDHNKVIGYDDVNQLFWYPE GIAKIVMEDGTRLIDLPAEERYLKLGEIPWDDVFFKTYKETRSWLHLVTNFNRIWIMHIS VYWMYCAYNAPTFYTHNYQQLVDNQPLAAYKWATAALGGTVASLIQVAATLCEWSFVPRK WAGAQHLSRRFWFLCVIMGINLGPVIFVFAYDKDTVYSTAAHVVGAVMFFVAVATLVFFS VMPLGGLFTSYMKKSTRSYVASQTFTASFAPLHGLDRWMSYLVWVTVFAAKYAESYFFLI LSLRDPIRILSTTSMRCTGEYWWGNKICKVQPKIVLGLMIATDFILFFLDTYLWYIVVNT VFSVGKSFYLGISILTPWRNIFTRLPKRIYSKILATTDMEIKYKPKVLISQIWNAIIISM YREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRDSEAERRISF FAQSLSTPIPEPLPVDNMPTFTVLTPHYAERILLSLREIIREDDQFSRVTLLEYLKQLHP VEWDCFVKDTKILAEETAAYENNEDEPEKEDALKSQIDDLPFYCIGFKSAAPEYTLRTRI WASLRSQTLYRTISGFMNYSRAIKLLYRVENPEIVQMFGGNADGLERELEKMARRKFKFL VSMQRLAKFKPHELENAEFLLRAYPDLQIAYLDEEPPLNEGEEPRIYSALIDGHCEILEN GRRRPKFRVQLSGNPILGDGKSDNQNHALIFYRGEYIQLIDANQDNYLEECLKIRSVLAE FEELGIEQIHPYTPGLKYEDQSTNHPVAIVGAREYIFSENSGVLGDVAAGKEQTFGTLFA RTLAQIGGKLHYGHPDFINATFMTTRGGVSKAQKGLHLNEDIYAGMNAVLRGGRIKHCEY YQCGKGRDLGFGTILNFTTKIGAGMGEQMLSREYYYLGTQLPIDRFLTFYYAHPGFHLNN LFIQLSLQMFMLTLVNLHALAHESILCVYDRDKPITDVLYPIGCYNFHPAIDWVRRYTLS IFIVFWIAFVPIVVQELIERGLWKATQRFFRHILSLSPMFEVFAGQIYSSALLSDIAVGG ARYISTGRGFATSRIPFSILYSRFAGSAIYMGSRSMLMLLFGTVAHWQAPLLWFWASLSA LIFAPFIFNPHQFAWEDFFLDYRDYIRWLSRGNNKYHRNSWIGYVRMSRSRVTGFKRKLV GDESEKSAGDASRAHRTNLIMAEIIPCAIYAAGCFIAFTFINAQTGVKTTDEDRVNSTLR IIICTLAPIVIDIGVLFFCMGLSCCSGPLLGMCCKKTGSVMAGIAHGIAVVVHIVFFIVM WVLEGFSFVRMLIGVVTCIQCQRLIFHCMTVLLLTREFKNDHANTAFWTGKWYSTGLGYM AWTQPTRELTAKVIELSEFAADFVLGHVILIFQLPVICIPKIDKFHSIMLFWLKPSRQIR PPIYSLKQARLRKRMVRRYCSLYFLVLIIFAGCIVGPAVASAHVPKDLGSGLTGTFHNLV QPRNVSNNDTGSQMSTYKSHYYTHTPSLKTWSTIK
- Number of residues
- 1895
- Molecular Weight
- 216987.85
- Theoretical pI
- Not Available
- GO Classification
- Functions1,3-beta-D-glucan synthase activity / glucosyltransferase activityProcesses(1->3)-beta-D-glucan biosynthetic process / ascospore wall assembly / fungal-type cell wall polysaccharide biosynthetic process / regulation of cell shapeComponents1,3-beta-D-glucan synthase complex / cell periphery / cellular bud neck / integral component of membrane / plasma membrane / prospore membrane
- General Function
- Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Required for spore wall assembly. Negative regulation of activity by SMK1 is important for spore wall deposition. Activity is positively regulated by RHO1.
- Specific Function
- 1,3-beta-d-glucan synthase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 474-494 512-532 551-571 583-603 1580-1600 1621-1641 1759-1779 1822-1842
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052582|1,3-beta-glucan synthase component GSC2 (GSC2) ATGTCCTACAACGATCCAAACTTGAATGGACAGTATTACAGTAACGGTGATGGGACTGGT GACGGTAATTACCCTACGTACCAAGTGACACAGGATCAAAGTGCGTACGATGAGTACGGT CAGCCAATCTATACACAAAACCAACTGGATGATGGTTATTATGATCCAAACGAACAATAC GTTGACGGTACACAATTTCCTCAGGGACAAGATCCTTCACAAGACCAAGGTCCTTATAAT AACGATGCTAGTTACTATAACCAACCCCCCAATATGATGAACCCGTCTTCTCAAGATGGA GAGAACTTCTCAGATTTTAGCAGCTATGGTCCCCCATCCGGCACTTATCCTAACGATCAA TATACTCCTTCTCAAATGAGTTATCCTGATCAAGATGGTTCTTCAGGGGCCTCAACCCCC TATGGAAATGGTGTCGTTAATGGTAATGGCCAGTACTACGACCCTAATGCTATTGAAATG GCTTTACCAAATGATCCATATCCCGCATGGACCGCAGATCCCCAGTCTCCCCTGCCCATC GAACAAATCGAAGATATCTTCATAGATTTAACAAATAAATTCGGTTTTCAGAGAGATTCC ATGAGAAATATGTTTGACCATTTTATGACCCTTTTGGACTCTAGATCTTCTAGGATGTCT CCAGAACAGGCCCTTTTATCATTACATGCAGACTACATAGGTGGAGATACGGCCAACTAC AAAAAATGGTACTTTGCCGCTCAACTTGATATGGATGATGAAATTGGTTTCAGGAATATG AAGTTGGGTAAGCTATCAAGAAAGGCAAGAAAGGCTAAGAAGAAAAATAAAAAAGCCATG CAAGAGGCTAGTCCTGAAGACACTGAGGAGACTTTAAATCAAATTGAGGGTGATAACTCA TTAGAAGCTGCGGATTTTAGATGGAAGTCAAAGATGAATCAACTTTCTCCATTTGAAATG GTTCGTCAAATTGCCTTGTTTTTATTATGTTGGGGCGAGGCAAATCAAGTCAGATTTACC CCGGAGTGTCTTTGTTTCATTTATAAATGCGCCTCTGATTACTTAGATTCTGCACAATGT CAACAACGTCCTGATCCCTTGCCTGAAGGTGATTTTTTGAATAGAGTTATTACTCCTCTT TATCGTTTTATTAGGAGCCAGGTTTACGAAATCGTGGATGGTCGATACGTGAAGAGTGAA AAAGATCATAACAAAGTTATTGGGTATGATGATGTCAATCAATTATTCTGGTATCCAGAA GGTATAGCAAAAATTGTCATGGAAGATGGAACCAGGTTGATTGATTTGCCAGCAGAGGAG CGTTATTTGAAATTGGGAGAAATTCCCTGGGATGATGTCTTCTTTAAAACTTACAAAGAA ACACGTTCCTGGTTACATTTAGTTACCAACTTCAATCGTATTTGGATCATGCACATCTCA GTATATTGGATGTATTGTGCTTACAATGCTCCAACTTTTTATACTCACAACTATCAACAA TTGGTCGACAATCAGCCTTTGGCAGCTTATAAATGGGCCACTGCAGCATTAGGTGGTACT GTGGCAAGTTTGATTCAAGTTGCCGCTACTTTGTGCGAGTGGTCATTCGTTCCTAGAAAA TGGGCGGGTGCTCAACATTTGTCCCGTAGATTCTGGTTCTTGTGTGTCATTATGGGTATT AATTTGGGGCCTGTGATATTTGTTTTCGCTTATGATAAGGACACAGTATATTCTACTGCC GCTCATGTCGTTGGAGCAGTTATGTTTTTTGTTGCTGTGGCAACACTTGTTTTCTTTTCC GTAATGCCATTGGGTGGATTATTTACATCGTATATGAAAAAGTCCACAAGAAGTTATGTT GCCTCACAGACCTTCACCGCATCTTTTGCTCCATTGCATGGTTTAGACAGGTGGATGTCT TATTTGGTTTGGGTAACCGTTTTTGCTGCTAAATATGCAGAGTCATATTTTTTTCTAATA CTGTCACTAAGAGATCCAATTAGGATTTTATCTACTACATCAATGAGATGTACTGGTGAA TACTGGTGGGGTAATAAGATTTGTAAGGTCCAGCCAAAGATTGTTTTAGGTTTAATGATT GCGACTGACTTCATTTTGTTCTTTTTGGATACCTACTTGTGGTATATCGTTGTTAACACT GTTTTCTCGGTCGGAAAATCGTTCTATTTGGGTATTTCTATCTTAACTCCATGGAGAAAT ATTTTCACTAGATTGCCAAAAAGAATTTATTCTAAGATCTTGGCTACTACTGATATGGAA ATAAAATATAAACCGAAAGTACTAATTTCTCAGATTTGGAATGCTATCATTATCTCCATG TACAGAGAACATTTATTAGCCATAGACCATGTACAAAAATTGTTATATCATCAGGTTCCG TCCGAAATTGAAGGTAAGAGGACTTTGAGAGCACCAACTTTCTTTGTTTCCCAAGATGAC AATAATTTTGAGACTGAATTTTTCCCTAGAGATTCAGAAGCTGAGCGCCGTATTTCATTT TTTGCCCAATCTCTATCCACTCCAATTCCAGAACCACTACCAGTTGACAACATGCCAACA TTTACTGTATTAACTCCCCATTACGCCGAGAGGATTCTATTATCATTGAGAGAAATTATT CGTGAAGATGATCAATTTTCAAGAGTTACTCTTTTGGAATACCTGAAGCAATTACACCCG GTAGAATGGGACTGTTTTGTTAAGGATACGAAAATTCTTGCTGAAGAAACGGCCGCATAT GAAAACAATGAAGATGAACCTGAAAAGGAAGACGCTCTGAAATCTCAAATTGATGATTTA CCTTTCTATTGTATTGGTTTCAAATCTGCTGCACCAGAATACACCTTACGTACGAGAATC TGGGCCTCTTTAAGGTCGCAAACTTTGTATCGCACAATCTCGGGGTTTATGAATTATTCG AGGGCCATAAAATTACTTTATCGTGTGGAAAATCCAGAAATCGTTCAAATGTTCGGTGGT AATGCTGATGGATTAGAAAGAGAACTGGAAAAAATGGCAAGGCGAAAATTCAAATTCTTG GTTTCGATGCAAAGATTGGCCAAGTTTAAACCACATGAACTAGAAAATGCTGAGTTCCTG TTGAGAGCTTATCCGGACTTGCAAATTGCCTACCTGGATGAAGAACCTCCCTTAAACGAA GGCGAAGAGCCAAGAATTTACTCGGCCTTAATTGATGGTCATTGTGAGATTTTAGAGAAT GGTCGTAGACGTCCCAAATTTAGAGTTCAACTATCCGGTAATCCAATTCTTGGTGATGGT AAATCAGATAATCAAAATCATGCTTTGATTTTTTACAGAGGTGAGTATATTCAATTGATT GATGCTAATCAAGACAATTACTTGGAAGAGTGTTTGAAAATCAGGTCTGTCTTAGCAGAA TTTGAAGAATTGGGAATTGAGCAAATTCATCCTTATACTCCTGGTTTAAAATATGAGGAC CAATCCACAAATCATCCTGTTGCAATTGTCGGCGCTAGAGAATATATTTTCTCAGAAAAC TCTGGTGTTCTTGGTGATGTAGCGGCTGGTAAAGAACAAACTTTTGGTACATTATTTGCC CGTACTTTGGCACAGATTGGTGGTAAATTGCATTATGGTCATCCAGATTTTATTAATGCG ACATTCATGACTACTAGGGGTGGTGTTTCCAAAGCACAAAAGGGTCTACATTTAAATGAA GATATTTATGCCGGTATGAATGCCGTACTTCGGGGTGGTCGTATCAAGCATTGCGAATAT TATCAGTGTGGTAAAGGTAGAGATTTAGGTTTTGGTACAATTTTGAATTTCACTACTAAG ATCGGTGCTGGTATGGGTGAACAAATGTTATCTCGTGAATACTATTATTTGGGTACGCAA TTACCTATTGACCGTTTTTTAACATTTTATTATGCGCATCCAGGGTTTCACTTGAATAAC TTATTTATTCAATTGTCTCTGCAGATGTTCATGTTAACTTTAGTGAACTTGCATGCTTTG GCTCATGAATCCATTCTGTGTGTTTACGATAGGGATAAGCCAATTACTGATGTTTTGTAT CCAATTGGTTGTTACAACTTTCATCCTGCGATTGATTGGGTGAGACGTTATACACTCTCT ATTTTCATCGTCTTTTGGATTGCTTTTGTCCCTATTGTCGTTCAGGAATTAATCGAGCGT GGTCTGTGGAAGGCGACACAAAGATTTTTCCGTCACATTTTATCTCTATCTCCAATGTTT GAAGTCTTTGCTGGCCAAATCTATTCTTCAGCACTGTTAAGTGATATCGCTGTGGGTGGT GCTCGTTATATTTCAACAGGTCGTGGCTTTGCTACATCTCGTATACCTTTCTCTATTCTT TATTCAAGATTTGCGGGTTCAGCCATTTATATGGGATCAAGATCAATGTTGATGTTATTA TTTGGTACCGTGGCACATTGGCAAGCTCCACTATTATGGTTTTGGGCATCATTATCAGCC TTAATCTTTGCACCATTCATTTTCAATCCACATCAATTTGCTTGGGAAGATTTTTTCCTA GACTACAGAGATTATATCAGATGGCTGTCAAGAGGTAATAATAAGTACCACAGGAACTCA TGGATTGGTTATGTAAGAATGTCGAGGTCTCGTGTTACTGGTTTCAAGCGCAAACTGGTG GGTGATGAGTCTGAAAAATCTGCAGGCGATGCAAGCAGGGCTCATAGAACCAATTTAATT ATGGCTGAAATTATACCGTGTGCGATTTACGCAGCAGGTTGTTTTATTGCCTTCACGTTT ATTAATGCACAAACTGGTGTCAAGACTACTGATGAAGATAGAGTAAATTCCACCTTACGT ATCATCATTTGCACCTTGGCGCCTATTGTTATCGATATTGGTGTTTTATTCTTCTGTATG GGTTTGTCATGCTGCTCTGGCCCTTTGTTGGGCATGTGCTGCAAGAAAACTGGTTCTGTT ATGGCAGGGATCGCTCACGGTATCGCTGTTGTTGTCCATATTGTCTTTTTCATTGTCATG TGGGTTTTAGAGGGTTTTAGTTTTGTTAGGATGTTGATTGGCGTTGTTACATGTATACAA TGTCAAAGGTTGATTTTTCACTGTATGACTGTACTGTTGCTGACCCGTGAGTTCAAGAAT GATCACGCTAATACTGCCTTTTGGACAGGCAAATGGTACAGCACCGGTTTAGGATATATG GCATGGACTCAACCGACAAGGGAATTGACTGCAAAAGTCATTGAGCTTTCCGAGTTTGCA GCGGATTTTGTTTTGGGGCATGTAATTTTGATCTTCCAACTACCAGTCATTTGTATTCCA AAGATAGATAAGTTTCACTCCATCATGTTATTTTGGTTAAAACCATCCCGTCAAATCCGT CCTCCTATTTACTCTTTGAAACAAGCACGCCTACGTAAACGTATGGTTAGGAGGTATTGC AGCTTGTACTTTTTGGTACTGATCATATTCGCGGGATGCATCGTTGGCCCTGCCGTTGCT TCAGCACATGTTCCAAAAGACCTTGGATCTGGGTTGACGGGTACTTTCCATAACTTGGTT CAACCAAGGAACGTATCTAACAATGATACAGGGTCCCAGATGTCTACTTATAAGAGTCAT TATTACACTCATACGCCATCCTTAAAGACCTGGTCTACGATCAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P40989 UniProtKB Entry Name FKS2_YEAST KEGG ID sce:YGR032W NCBI Gene ID 852920 - General References
- Inoue SB, Takewaki N, Takasuka T, Mio T, Adachi M, Fujii Y, Miyamoto C, Arisawa M, Furuichi Y, Watanabe T: Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae. Eur J Biochem. 1995 Aug 1;231(3):845-54. doi: 10.1111/j.1432-1033.1995.tb20770.x. [Article]
- Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F: Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 1995 Oct;15(10):5671-81. doi: 10.1128/MCB.15.10.5671. [Article]
- Deutschbauer AM, Davis RW: Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat Genet. 2005 Dec;37(12):1333-40. doi: 10.1038/ng1674. Epub 2005 Nov 6. [Article]
- Rieger M, Bruckner M, Schafer M, Muller-Auer S: Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII. Yeast. 1997 Sep 15;13(11):1077-90. doi: 10.1002/(SICI)1097-0061(19970915)13:11<1077::AID-YEA152>3.0.CO;2-Y. [Article]
- Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Bruckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature. 1997 May 29;387(6632 Suppl):81-4. [Article]
- Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995. [Article]
- Mazur P, Baginsky W: In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1. J Biol Chem. 1996 Jun 14;271(24):14604-9. doi: 10.1074/jbc.271.24.14604. [Article]
- Lesage G, Sdicu AM, Menard P, Shapiro J, Hussein S, Bussey H: Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics. 2004 May;167(1):35-49. doi: 10.1534/genetics.167.1.35. [Article]
- Huang LS, Doherty HK, Herskowitz I: The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12431-6. doi: 10.1073/pnas.0502324102. Epub 2005 Aug 22. [Article]
- Kim H, Melen K, Osterberg M, von Heijne G: A global topology map of the Saccharomyces cerevisiae membrane proteome. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11142-7. Epub 2006 Jul 17. [Article]
- Ishihara S, Hirata A, Nogami S, Beauvais A, Latge JP, Ohya Y: Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae. Eukaryot Cell. 2007 Feb;6(2):143-56. doi: 10.1128/EC.00200-06. Epub 2006 Dec 8. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type 1,3-beta-glucan synthase component GSC2 (Baker's yeast) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Ibrexafungerp approved, investigational yes target inhibitor Details Rezafungin approved, investigational yes target inhibitor Details Caspofungin approved yes target modulator Details Micafungin approved, investigational yes target modulator Details Anidulafungin approved, investigational yes target modulator Details