1,3-beta-glucan synthase component GSC2

Details

Name
1,3-beta-glucan synthase component GSC2
Synonyms
  • 1,3-beta-D-glucan-UDP glucosyltransferase
  • 2.4.1.34
  • FK506 sensitivity protein 2
  • FKS2
  • GLS2
  • Glucan synthase of cerevisiae protein 2
Gene Name
GSC2
Organism
Baker's yeast
Amino acid sequence
>lcl|BSEQ0052581|1,3-beta-glucan synthase component GSC2
MSYNDPNLNGQYYSNGDGTGDGNYPTYQVTQDQSAYDEYGQPIYTQNQLDDGYYDPNEQY
VDGTQFPQGQDPSQDQGPYNNDASYYNQPPNMMNPSSQDGENFSDFSSYGPPSGTYPNDQ
YTPSQMSYPDQDGSSGASTPYGNGVVNGNGQYYDPNAIEMALPNDPYPAWTADPQSPLPI
EQIEDIFIDLTNKFGFQRDSMRNMFDHFMTLLDSRSSRMSPEQALLSLHADYIGGDTANY
KKWYFAAQLDMDDEIGFRNMKLGKLSRKARKAKKKNKKAMQEASPEDTEETLNQIEGDNS
LEAADFRWKSKMNQLSPFEMVRQIALFLLCWGEANQVRFTPECLCFIYKCASDYLDSAQC
QQRPDPLPEGDFLNRVITPLYRFIRSQVYEIVDGRYVKSEKDHNKVIGYDDVNQLFWYPE
GIAKIVMEDGTRLIDLPAEERYLKLGEIPWDDVFFKTYKETRSWLHLVTNFNRIWIMHIS
VYWMYCAYNAPTFYTHNYQQLVDNQPLAAYKWATAALGGTVASLIQVAATLCEWSFVPRK
WAGAQHLSRRFWFLCVIMGINLGPVIFVFAYDKDTVYSTAAHVVGAVMFFVAVATLVFFS
VMPLGGLFTSYMKKSTRSYVASQTFTASFAPLHGLDRWMSYLVWVTVFAAKYAESYFFLI
LSLRDPIRILSTTSMRCTGEYWWGNKICKVQPKIVLGLMIATDFILFFLDTYLWYIVVNT
VFSVGKSFYLGISILTPWRNIFTRLPKRIYSKILATTDMEIKYKPKVLISQIWNAIIISM
YREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRDSEAERRISF
FAQSLSTPIPEPLPVDNMPTFTVLTPHYAERILLSLREIIREDDQFSRVTLLEYLKQLHP
VEWDCFVKDTKILAEETAAYENNEDEPEKEDALKSQIDDLPFYCIGFKSAAPEYTLRTRI
WASLRSQTLYRTISGFMNYSRAIKLLYRVENPEIVQMFGGNADGLERELEKMARRKFKFL
VSMQRLAKFKPHELENAEFLLRAYPDLQIAYLDEEPPLNEGEEPRIYSALIDGHCEILEN
GRRRPKFRVQLSGNPILGDGKSDNQNHALIFYRGEYIQLIDANQDNYLEECLKIRSVLAE
FEELGIEQIHPYTPGLKYEDQSTNHPVAIVGAREYIFSENSGVLGDVAAGKEQTFGTLFA
RTLAQIGGKLHYGHPDFINATFMTTRGGVSKAQKGLHLNEDIYAGMNAVLRGGRIKHCEY
YQCGKGRDLGFGTILNFTTKIGAGMGEQMLSREYYYLGTQLPIDRFLTFYYAHPGFHLNN
LFIQLSLQMFMLTLVNLHALAHESILCVYDRDKPITDVLYPIGCYNFHPAIDWVRRYTLS
IFIVFWIAFVPIVVQELIERGLWKATQRFFRHILSLSPMFEVFAGQIYSSALLSDIAVGG
ARYISTGRGFATSRIPFSILYSRFAGSAIYMGSRSMLMLLFGTVAHWQAPLLWFWASLSA
LIFAPFIFNPHQFAWEDFFLDYRDYIRWLSRGNNKYHRNSWIGYVRMSRSRVTGFKRKLV
GDESEKSAGDASRAHRTNLIMAEIIPCAIYAAGCFIAFTFINAQTGVKTTDEDRVNSTLR
IIICTLAPIVIDIGVLFFCMGLSCCSGPLLGMCCKKTGSVMAGIAHGIAVVVHIVFFIVM
WVLEGFSFVRMLIGVVTCIQCQRLIFHCMTVLLLTREFKNDHANTAFWTGKWYSTGLGYM
AWTQPTRELTAKVIELSEFAADFVLGHVILIFQLPVICIPKIDKFHSIMLFWLKPSRQIR
PPIYSLKQARLRKRMVRRYCSLYFLVLIIFAGCIVGPAVASAHVPKDLGSGLTGTFHNLV
QPRNVSNNDTGSQMSTYKSHYYTHTPSLKTWSTIK
Number of residues
1895
Molecular Weight
216987.85
Theoretical pI
Not Available
GO Classification
Functions
1,3-beta-D-glucan synthase activity / glucosyltransferase activity
Processes
(1->3)-beta-D-glucan biosynthetic process / ascospore wall assembly / fungal-type cell wall polysaccharide biosynthetic process / regulation of cell shape
Components
1,3-beta-D-glucan synthase complex / cell periphery / cellular bud neck / integral component of membrane / plasma membrane / prospore membrane
General Function
Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Required for spore wall assembly. Negative regulation of activity by SMK1 is important for spore wall deposition. Activity is positively regulated by RHO1.
Specific Function
1,3-beta-d-glucan synthase activity
Pfam Domain Function
Transmembrane Regions
474-494 512-532 551-571 583-603 1580-1600 1621-1641 1759-1779 1822-1842
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0052582|1,3-beta-glucan synthase component GSC2 (GSC2)
ATGTCCTACAACGATCCAAACTTGAATGGACAGTATTACAGTAACGGTGATGGGACTGGT
GACGGTAATTACCCTACGTACCAAGTGACACAGGATCAAAGTGCGTACGATGAGTACGGT
CAGCCAATCTATACACAAAACCAACTGGATGATGGTTATTATGATCCAAACGAACAATAC
GTTGACGGTACACAATTTCCTCAGGGACAAGATCCTTCACAAGACCAAGGTCCTTATAAT
AACGATGCTAGTTACTATAACCAACCCCCCAATATGATGAACCCGTCTTCTCAAGATGGA
GAGAACTTCTCAGATTTTAGCAGCTATGGTCCCCCATCCGGCACTTATCCTAACGATCAA
TATACTCCTTCTCAAATGAGTTATCCTGATCAAGATGGTTCTTCAGGGGCCTCAACCCCC
TATGGAAATGGTGTCGTTAATGGTAATGGCCAGTACTACGACCCTAATGCTATTGAAATG
GCTTTACCAAATGATCCATATCCCGCATGGACCGCAGATCCCCAGTCTCCCCTGCCCATC
GAACAAATCGAAGATATCTTCATAGATTTAACAAATAAATTCGGTTTTCAGAGAGATTCC
ATGAGAAATATGTTTGACCATTTTATGACCCTTTTGGACTCTAGATCTTCTAGGATGTCT
CCAGAACAGGCCCTTTTATCATTACATGCAGACTACATAGGTGGAGATACGGCCAACTAC
AAAAAATGGTACTTTGCCGCTCAACTTGATATGGATGATGAAATTGGTTTCAGGAATATG
AAGTTGGGTAAGCTATCAAGAAAGGCAAGAAAGGCTAAGAAGAAAAATAAAAAAGCCATG
CAAGAGGCTAGTCCTGAAGACACTGAGGAGACTTTAAATCAAATTGAGGGTGATAACTCA
TTAGAAGCTGCGGATTTTAGATGGAAGTCAAAGATGAATCAACTTTCTCCATTTGAAATG
GTTCGTCAAATTGCCTTGTTTTTATTATGTTGGGGCGAGGCAAATCAAGTCAGATTTACC
CCGGAGTGTCTTTGTTTCATTTATAAATGCGCCTCTGATTACTTAGATTCTGCACAATGT
CAACAACGTCCTGATCCCTTGCCTGAAGGTGATTTTTTGAATAGAGTTATTACTCCTCTT
TATCGTTTTATTAGGAGCCAGGTTTACGAAATCGTGGATGGTCGATACGTGAAGAGTGAA
AAAGATCATAACAAAGTTATTGGGTATGATGATGTCAATCAATTATTCTGGTATCCAGAA
GGTATAGCAAAAATTGTCATGGAAGATGGAACCAGGTTGATTGATTTGCCAGCAGAGGAG
CGTTATTTGAAATTGGGAGAAATTCCCTGGGATGATGTCTTCTTTAAAACTTACAAAGAA
ACACGTTCCTGGTTACATTTAGTTACCAACTTCAATCGTATTTGGATCATGCACATCTCA
GTATATTGGATGTATTGTGCTTACAATGCTCCAACTTTTTATACTCACAACTATCAACAA
TTGGTCGACAATCAGCCTTTGGCAGCTTATAAATGGGCCACTGCAGCATTAGGTGGTACT
GTGGCAAGTTTGATTCAAGTTGCCGCTACTTTGTGCGAGTGGTCATTCGTTCCTAGAAAA
TGGGCGGGTGCTCAACATTTGTCCCGTAGATTCTGGTTCTTGTGTGTCATTATGGGTATT
AATTTGGGGCCTGTGATATTTGTTTTCGCTTATGATAAGGACACAGTATATTCTACTGCC
GCTCATGTCGTTGGAGCAGTTATGTTTTTTGTTGCTGTGGCAACACTTGTTTTCTTTTCC
GTAATGCCATTGGGTGGATTATTTACATCGTATATGAAAAAGTCCACAAGAAGTTATGTT
GCCTCACAGACCTTCACCGCATCTTTTGCTCCATTGCATGGTTTAGACAGGTGGATGTCT
TATTTGGTTTGGGTAACCGTTTTTGCTGCTAAATATGCAGAGTCATATTTTTTTCTAATA
CTGTCACTAAGAGATCCAATTAGGATTTTATCTACTACATCAATGAGATGTACTGGTGAA
TACTGGTGGGGTAATAAGATTTGTAAGGTCCAGCCAAAGATTGTTTTAGGTTTAATGATT
GCGACTGACTTCATTTTGTTCTTTTTGGATACCTACTTGTGGTATATCGTTGTTAACACT
GTTTTCTCGGTCGGAAAATCGTTCTATTTGGGTATTTCTATCTTAACTCCATGGAGAAAT
ATTTTCACTAGATTGCCAAAAAGAATTTATTCTAAGATCTTGGCTACTACTGATATGGAA
ATAAAATATAAACCGAAAGTACTAATTTCTCAGATTTGGAATGCTATCATTATCTCCATG
TACAGAGAACATTTATTAGCCATAGACCATGTACAAAAATTGTTATATCATCAGGTTCCG
TCCGAAATTGAAGGTAAGAGGACTTTGAGAGCACCAACTTTCTTTGTTTCCCAAGATGAC
AATAATTTTGAGACTGAATTTTTCCCTAGAGATTCAGAAGCTGAGCGCCGTATTTCATTT
TTTGCCCAATCTCTATCCACTCCAATTCCAGAACCACTACCAGTTGACAACATGCCAACA
TTTACTGTATTAACTCCCCATTACGCCGAGAGGATTCTATTATCATTGAGAGAAATTATT
CGTGAAGATGATCAATTTTCAAGAGTTACTCTTTTGGAATACCTGAAGCAATTACACCCG
GTAGAATGGGACTGTTTTGTTAAGGATACGAAAATTCTTGCTGAAGAAACGGCCGCATAT
GAAAACAATGAAGATGAACCTGAAAAGGAAGACGCTCTGAAATCTCAAATTGATGATTTA
CCTTTCTATTGTATTGGTTTCAAATCTGCTGCACCAGAATACACCTTACGTACGAGAATC
TGGGCCTCTTTAAGGTCGCAAACTTTGTATCGCACAATCTCGGGGTTTATGAATTATTCG
AGGGCCATAAAATTACTTTATCGTGTGGAAAATCCAGAAATCGTTCAAATGTTCGGTGGT
AATGCTGATGGATTAGAAAGAGAACTGGAAAAAATGGCAAGGCGAAAATTCAAATTCTTG
GTTTCGATGCAAAGATTGGCCAAGTTTAAACCACATGAACTAGAAAATGCTGAGTTCCTG
TTGAGAGCTTATCCGGACTTGCAAATTGCCTACCTGGATGAAGAACCTCCCTTAAACGAA
GGCGAAGAGCCAAGAATTTACTCGGCCTTAATTGATGGTCATTGTGAGATTTTAGAGAAT
GGTCGTAGACGTCCCAAATTTAGAGTTCAACTATCCGGTAATCCAATTCTTGGTGATGGT
AAATCAGATAATCAAAATCATGCTTTGATTTTTTACAGAGGTGAGTATATTCAATTGATT
GATGCTAATCAAGACAATTACTTGGAAGAGTGTTTGAAAATCAGGTCTGTCTTAGCAGAA
TTTGAAGAATTGGGAATTGAGCAAATTCATCCTTATACTCCTGGTTTAAAATATGAGGAC
CAATCCACAAATCATCCTGTTGCAATTGTCGGCGCTAGAGAATATATTTTCTCAGAAAAC
TCTGGTGTTCTTGGTGATGTAGCGGCTGGTAAAGAACAAACTTTTGGTACATTATTTGCC
CGTACTTTGGCACAGATTGGTGGTAAATTGCATTATGGTCATCCAGATTTTATTAATGCG
ACATTCATGACTACTAGGGGTGGTGTTTCCAAAGCACAAAAGGGTCTACATTTAAATGAA
GATATTTATGCCGGTATGAATGCCGTACTTCGGGGTGGTCGTATCAAGCATTGCGAATAT
TATCAGTGTGGTAAAGGTAGAGATTTAGGTTTTGGTACAATTTTGAATTTCACTACTAAG
ATCGGTGCTGGTATGGGTGAACAAATGTTATCTCGTGAATACTATTATTTGGGTACGCAA
TTACCTATTGACCGTTTTTTAACATTTTATTATGCGCATCCAGGGTTTCACTTGAATAAC
TTATTTATTCAATTGTCTCTGCAGATGTTCATGTTAACTTTAGTGAACTTGCATGCTTTG
GCTCATGAATCCATTCTGTGTGTTTACGATAGGGATAAGCCAATTACTGATGTTTTGTAT
CCAATTGGTTGTTACAACTTTCATCCTGCGATTGATTGGGTGAGACGTTATACACTCTCT
ATTTTCATCGTCTTTTGGATTGCTTTTGTCCCTATTGTCGTTCAGGAATTAATCGAGCGT
GGTCTGTGGAAGGCGACACAAAGATTTTTCCGTCACATTTTATCTCTATCTCCAATGTTT
GAAGTCTTTGCTGGCCAAATCTATTCTTCAGCACTGTTAAGTGATATCGCTGTGGGTGGT
GCTCGTTATATTTCAACAGGTCGTGGCTTTGCTACATCTCGTATACCTTTCTCTATTCTT
TATTCAAGATTTGCGGGTTCAGCCATTTATATGGGATCAAGATCAATGTTGATGTTATTA
TTTGGTACCGTGGCACATTGGCAAGCTCCACTATTATGGTTTTGGGCATCATTATCAGCC
TTAATCTTTGCACCATTCATTTTCAATCCACATCAATTTGCTTGGGAAGATTTTTTCCTA
GACTACAGAGATTATATCAGATGGCTGTCAAGAGGTAATAATAAGTACCACAGGAACTCA
TGGATTGGTTATGTAAGAATGTCGAGGTCTCGTGTTACTGGTTTCAAGCGCAAACTGGTG
GGTGATGAGTCTGAAAAATCTGCAGGCGATGCAAGCAGGGCTCATAGAACCAATTTAATT
ATGGCTGAAATTATACCGTGTGCGATTTACGCAGCAGGTTGTTTTATTGCCTTCACGTTT
ATTAATGCACAAACTGGTGTCAAGACTACTGATGAAGATAGAGTAAATTCCACCTTACGT
ATCATCATTTGCACCTTGGCGCCTATTGTTATCGATATTGGTGTTTTATTCTTCTGTATG
GGTTTGTCATGCTGCTCTGGCCCTTTGTTGGGCATGTGCTGCAAGAAAACTGGTTCTGTT
ATGGCAGGGATCGCTCACGGTATCGCTGTTGTTGTCCATATTGTCTTTTTCATTGTCATG
TGGGTTTTAGAGGGTTTTAGTTTTGTTAGGATGTTGATTGGCGTTGTTACATGTATACAA
TGTCAAAGGTTGATTTTTCACTGTATGACTGTACTGTTGCTGACCCGTGAGTTCAAGAAT
GATCACGCTAATACTGCCTTTTGGACAGGCAAATGGTACAGCACCGGTTTAGGATATATG
GCATGGACTCAACCGACAAGGGAATTGACTGCAAAAGTCATTGAGCTTTCCGAGTTTGCA
GCGGATTTTGTTTTGGGGCATGTAATTTTGATCTTCCAACTACCAGTCATTTGTATTCCA
AAGATAGATAAGTTTCACTCCATCATGTTATTTTGGTTAAAACCATCCCGTCAAATCCGT
CCTCCTATTTACTCTTTGAAACAAGCACGCCTACGTAAACGTATGGTTAGGAGGTATTGC
AGCTTGTACTTTTTGGTACTGATCATATTCGCGGGATGCATCGTTGGCCCTGCCGTTGCT
TCAGCACATGTTCCAAAAGACCTTGGATCTGGGTTGACGGGTACTTTCCATAACTTGGTT
CAACCAAGGAACGTATCTAACAATGATACAGGGTCCCAGATGTCTACTTATAAGAGTCAT
TATTACACTCATACGCCATCCTTAAAGACCTGGTCTACGATCAAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP40989
UniProtKB Entry NameFKS2_YEAST
General References
  1. Inoue SB, Takewaki N, Takasuka T, Mio T, Adachi M, Fujii Y, Miyamoto C, Arisawa M, Furuichi Y, Watanabe T: Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae. Eur J Biochem. 1995 Aug 1;231(3):845-54. doi: 10.1111/j.1432-1033.1995.tb20770.x. [Article]
  2. Mazur P, Morin N, Baginsky W, el-Sherbeini M, Clemas JA, Nielsen JB, Foor F: Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol. 1995 Oct;15(10):5671-81. doi: 10.1128/MCB.15.10.5671. [Article]
  3. Deutschbauer AM, Davis RW: Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat Genet. 2005 Dec;37(12):1333-40. doi: 10.1038/ng1674. Epub 2005 Nov 6. [Article]
  4. Rieger M, Bruckner M, Schafer M, Muller-Auer S: Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII. Yeast. 1997 Sep 15;13(11):1077-90. doi: 10.1002/(SICI)1097-0061(19970915)13:11<1077::AID-YEA152>3.0.CO;2-Y. [Article]
  5. Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Bruckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature. 1997 May 29;387(6632 Suppl):81-4. [Article]
  6. Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995. [Article]
  7. Mazur P, Baginsky W: In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1. J Biol Chem. 1996 Jun 14;271(24):14604-9. doi: 10.1074/jbc.271.24.14604. [Article]
  8. Lesage G, Sdicu AM, Menard P, Shapiro J, Hussein S, Bussey H: Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics. 2004 May;167(1):35-49. doi: 10.1534/genetics.167.1.35. [Article]
  9. Huang LS, Doherty HK, Herskowitz I: The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12431-6. doi: 10.1073/pnas.0502324102. Epub 2005 Aug 22. [Article]
  10. Kim H, Melen K, Osterberg M, von Heijne G: A global topology map of the Saccharomyces cerevisiae membrane proteome. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11142-7. Epub 2006 Jul 17. [Article]
  11. Ishihara S, Hirata A, Nogami S, Beauvais A, Latge JP, Ohya Y: Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae. Eukaryot Cell. 2007 Feb;6(2):143-56. doi: 10.1128/EC.00200-06. Epub 2006 Dec 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12471Ibrexafungerpapproved, investigationalunknowninhibitorDetails
DB16310Rezafunginapproved, investigationalyesinhibitorDetails