C-X-C chemokine receptor type 4

Details

Name
C-X-C chemokine receptor type 4
Synonyms
  • CXC-R4
  • FB22
  • Fusin
  • HM89
  • LAP-3
  • LCR1
  • LESTR
  • Leukocyte-derived seven transmembrane domain receptor
  • Lipopolysaccharide-associated protein 3
  • LPS-associated protein 3
  • NPYRL
  • SDF-1 receptor
  • Stromal cell-derived factor 1 receptor
Gene Name
CXCR4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001830|C-X-C chemokine receptor type 4
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Number of residues
352
Molecular Weight
39745.055
Theoretical pI
8.3
GO Classification
Functions
actin binding / C-X-C chemokine receptor activity / coreceptor activity / G-protein coupled receptor activity / myosin light chain binding / ubiquitin binding / ubiquitin protein ligase binding / virus receptor activity
Processes
activation of MAPK activity / apoptotic process / calcium-mediated signaling / cellular response to cytokine stimulus / chemokine-mediated signaling pathway / dendritic cell chemotaxis / entry into host cell / G-protein coupled receptor signaling pathway / inflammatory response / myelin maintenance / neutrophil activation / positive regulation of cytosolic calcium ion concentration / positive regulation of oligodendrocyte differentiation / regulation of chemotaxis / response to hypoxia / response to virus / viral process
Components
cell junction / cell leading edge / cell surface / cytoplasm / cytoplasmic membrane-bounded vesicle / cytoplasmic vesicle / cytosol / early endosome / extracellular exosome / integral component of membrane / late endosome / lysosome / plasma membrane
General Function
Virus receptor activity
Specific Function
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:9427609, PubMed:10074122, PubMed:10756055). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Pfam Domain Function
Transmembrane Regions
39-63 78-99 111-130 155-174 196-216 242-261 283-302
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010646|C-X-C chemokine receptor type 4 (CXCR4)
ATGTCCATTCCTTTGCCTCTTTTGCAGATATACACTTCAGATAACTACACCGAGGAAATG
GGCTCAGGGGACTATGACTCCATGAAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTC
AATAAAATCTTCCTGCCCACCATCTACTCCATCATCTTCTTAACTGGCATTGTGGGCAAT
GGATTGGTCATCCTGGTCATGGGTTACCAGAAGAAACTGAGAAGCATGACGGACAAGTAC
AGGCTGCACCTGTCAGTGGCCGACCTCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTT
GATGCCGTGGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCAGTCCATGTCATCTAC
ACAGTCAACCTCTACAGCAGTGTCCTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTG
GCCATCGTCCACGCCACCAACAGTCAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTC
TATGTTGGCGTCTGGATCCCTGCCCTCCTGCTGACTATTCCCGACTTCATCTTTGCCAAC
GTCAGTGAGGCAGATGACAGATATATCTGTGACCGCTTCTACCCCAATGACTTGTGGGTG
GTTGTGTTCCAGTTTCAGCACATCATGGTTGGCCTTATCCTGCCTGGTATTGTCATCCTG
TCCTGCTATTGCATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAG
GCCCTCAAGACCACAGTCATCCTCATCCTGGCTTTCTTCGCCTGTTGGCTGCCTTACTAC
ATTGGGATCAGCATCGACTCCTTCATCCTCCTGGAAATCATCAAGCAAGGGTGTGAGTTT
GAGAACACTGTGCACAAGTGGATTTCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGT
CTGAACCCCATCCTCTATGCTTTCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCA
CTCACCTCTGTGAGCAGAGGGTCCAGCCTCAAGATCCTCTCCAAAGGAAAGCGAGGTGGA
CATTCATCTGTTTCCACTGAGTCTGAGTCTTCAAGTTTTCACTCCAGCTAA
Chromosome Location
2
Locus
2q21
External Identifiers
ResourceLink
UniProtKB IDP61073
UniProtKB Entry NameCXCR4_HUMAN
GenBank Protein ID189314
GenBank Gene IDL01639
GenAtlas IDCXCR4
HGNC IDHGNC:2561
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00452FramycetinapprovedunknownantagonistDetails
DB05501AMD-070investigationalunknownantagonistinhibitorDetails
DB06809PlerixaforapprovedyesantagonistinhibitorDetails
DB12698Ibalizumabapproved, investigationalunknownantagonistDetails
DB00181Baclofenapprovedunknownallosteric modulatorDetails
DB12715MSX-122investigationalunknownantagonistpartial antagonistDetails
DB12018UlocuplumabinvestigationalyesinhibitorDetails