Eukaryotic translation initiation factor 4E-binding protein 1

Details

Name
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms
  • 4E-BP1
  • PHAS-I
  • Phosphorylated heat- and acid-stable protein regulated by insulin 1
Gene Name
EIF4EBP1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052616|Eukaryotic translation initiation factor 4E-binding protein 1
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLM
ECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
Number of residues
118
Molecular Weight
12579.875
Theoretical pI
Not Available
GO Classification
Functions
eukaryotic initiation factor 4E binding / protein phosphatase 2A binding / translation repressor activity
Processes
cellular response to hypoxia / G1/S transition of mitotic cell cycle / lung development / negative regulation of protein-containing complex assembly / negative regulation of translational initiation / positive regulation of mitotic cell cycle / response to amino acid starvation / response to ethanol / response to ischemia / TOR signaling
Components
cytoplasm / cytosol / glutamatergic synapse / nucleus / postsynaptic cytosol / protein-containing complex
General Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Specific Function
Eukaryotic initiation factor 4e binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0052617|Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
ATGTCCGGGGGCAGCAGCTGCAGCCAGACCCCAAGCCGGGCCATCCCCGCCACTCGCCGG
GTGGTGCTCGGCGACGGCGTGCAGCTCCCGCCCGGGGACTACAGCACGACCCCCGGCGGC
ACGCTCTTCAGCACCACCCCGGGAGGTACCAGGATCATCTATGACCGGAAATTCCTGATG
GAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGG
GTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAAT
AGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATTTAA
Chromosome Location
8
Locus
8p11.23
External Identifiers
ResourceLink
UniProtKB IDQ13541
UniProtKB Entry Name4EBP1_HUMAN
HGNC IDHGNC:3288
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails