Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

Details

Name
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
Synonyms
  • 6.2.1.4
  • GTP-specific succinyl-CoA synthetase subunit beta
  • SCS-betaG
  • Succinyl-CoA synthetase beta-G chain
Gene Name
SUCLG2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000707|Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQM
IGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLED
AAKKAVASVAKK
Number of residues
432
Molecular Weight
46510.215
Theoretical pI
6.18
GO Classification
Functions
ATP binding / GTP binding / succinate-CoA ligase (GDP-forming) activity
Processes
cellular metabolic process / small molecule metabolic process / succinyl-CoA metabolic process / tricarboxylic acid cycle
Components
microtubule organizing center / mitochondrial matrix / mitochondrion / nucleus / plasma membrane
General Function
Succinate-coa ligase (gdp-forming) activity
Specific Function
Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion
Gene sequence
>lcl|BSEQ0010259|Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2)
ATGGCGTCCCCCGTAGCAGCGCAGGCCGGGAAGCTTCTGCGAGCCCTAGCGCTGCGGCCC
CGCTTCCTGGCGGCCGGGTCCCAGGCAGTTCAATTAACCTCCAGAAGATGGCTGAACCTG
CAGGAATACCAGAGCAAGAAACTGATGTCTGACAACGGAGTGAGAGTTCAAAGATTCTTT
GTAGCAGACACTGCAAATGAAGCTCTCGAGGCTGCTAAGAGACTAAATGCAAAAGAAATT
GTTTTAAAAGCCCAGATCTTAGCTGGAGGAAGAGGAAAAGGTGTCTTCAATAGTGGTTTG
AAAGGAGGTGTTCATTTAACAAAAGACCCTAATGTTGTGGGACAGCTGGCTAAACAGATG
ATTGGGTACAATCTAGCGACAAAACAAACTCCAAAAGAAGGTGTGAAAGTTAACAAGGTG
ATGGTTGCTGAAGCCTTGGATATTTCCAGAGAAACCTACCTGGCAATTCTGATGGACCGG
TCCTGCAATGGCCCCGTGCTGGTGGGCAGCCCCCAGGGGGGCGTCGACATTGAAGAGGTG
GCTGCTTCAAACCCGGAGCTCATTTTTAAGGAGCAAATTGACATTTTTGAAGGAATAAAG
GACAGCCAAGCTCAGCGGATGGCCGAAAATCTAGGCTTCGTTGGGCCTTTGAAAAGCCAG
GCTGCAGATCAAATTACGAAGCTGTATAATCTCTTCCTGAAAATTGATGCTACTCAGGTG
GAAGTGAATCCCTTTGGTGAAACTCCAGAAGGACAAGTTGTCTGTTTTGATGCCAAGATA
AACTTTGATGACAACGCAGAATTCCGACAAAAAGACATATTTGCTATGGACGACAAATCA
GAGAATGAGCCCATTGAAAATGAAGCTGCCAAATATGATCTAAAATACATAGGACTAGAT
GGGAACATTGCCTGCTTTGTGAATGGTGCTGGGCTCGCCATGGCTACTTGTGATATCATT
TTCCTTAATGGTGGGAAGCCAGCCAACTTCTTGGATCTTGGAGGTGGTGTAAAGGAAGCT
CAAGTATATCAAGCATTCAAATTGCTCACAGCTGATCCTAAGGTTGAAGCCATCCTTGTC
AATATATTTGGTGGTATCGTCAACTGTGCCATCATTGCCAATGGGATCACCAAAGCCTGC
CGGGAGCTAGAACTCAAGGTGCCCCTGGTGGTCCGGCTTGAAGGTACTTTTATGGAAAAA
AAAGGAAGTTATATGCACATAAAACAAGAAACAGGAAATTCAAATGAGAATATAACTGGT
ATCCAAGAGAACGTCGCCCACCAAAATCTGAGTAAGTGTGCCATCAGCATTTTTTTATGT
TAA
Chromosome Location
3
Locus
3p14.1
External Identifiers
ResourceLink
UniProtKB IDQ96I99
UniProtKB Entry NameSUCB2_HUMAN
GenBank Protein ID133777003
GenBank Gene IDBC007716
GenAtlas IDSUCLG2
HGNC IDHGNC:11450
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails
DB00139Succinic acidapproved, nutraceuticalunknownproduct ofDetails
DB00787AcyclovirapprovedyessubstrateDetails