Serine/threonine-protein kinase SIK2

Details

Name
Serine/threonine-protein kinase SIK2
Synonyms
  • 2.7.11.1
  • KIAA0781
  • QIK
  • Qin-induced kinase
  • Salt-inducible kinase 2
  • Serine/threonine-protein kinase SNF1-like kinase 2
  • SIK-2
  • SNF1LK2
Gene Name
SIK2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051953|Serine/threonine-protein kinase SIK2
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN
LEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEAR
RKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSP
PYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFM
SEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQV
LRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTI
AEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDT
PKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQ
RRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIML
ANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQ
HLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVST
LPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQK
RLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEP
SSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPA
PLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLAL
SELPGLFDCEMLDAVDPQHNGYVLVN
Number of residues
926
Molecular Weight
103914.445
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / magnesium ion binding / protein serine/threonine kinase activity
Processes
cellular response to hormone stimulus / intracellular signal transduction / protein autophosphorylation / protein phosphorylation / regulation of insulin receptor signaling pathway
Components
cytoplasm / nucleus
General Function
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051954|Serine/threonine-protein kinase SIK2 (SIK2)
ATGGTCATGGCGGATGGCCCGAGGCACTTGCAGCGCGGGCCGGTCCGGGTGGGGTTCTAC
GACATCGAGGGCACGCTGGGCAAGGGCAACTTCGCTGTGGTGAAGCTGGGGCGGCACCGG
ATCACCAAGACGGAGGTGGCAATAAAAATAATCGATAAGTCTCAGCTGGATGCAGTGAAC
CTTGAGAAAATCTACCGAGAAGTACAAATAATGAAAATGTTAGACCACCCTCACATAATC
AAACTTTATCAGGTAATGGAGACCAAAAGTATGTTGTACCTTGTGACAGAATATGCCAAA
AATGGAGAAATTTTTGACTATCTTGCTAATCATGGCCGGTTAAATGAGTCTGAAGCCAGG
CGAAAATTCTGGCAAATCCTGTCTGCTGTTGATTATTGTCATGGTCGGAAGATTGTGCAC
CGTGACCTCAAAGCTGAAAATCTCCTGCTGGATAACAACATGAATATCAAAATAGCAGAT
TTCGGTTTTGGAAATTTCTTTAAAAGTGGTGAACTGCTGGCAACATGGTGTGGCAGCCCC
CCTTATGCAGCCCCAGAAGTCTTTGAAGGGCAGCAGTATGAAGGACCACAGCTGGACATC
TGGAGTATGGGAGTTGTTCTTTATGTCCTTGTCTGTGGAGCTCTGCCCTTTGATGGACCG
ACTCTTCCAATTTTGAGGCAGAGGGTTCTGGAAGGAAGATTCCGGATTCCGTATTTCATG
TCAGAAGATTGCGAGCACCTTATCCGAAGGATGTTGGTCCTAGACCCATCCAAACGGCTA
ACCATAGCCCAAATCAAGGAGCATAAATGGATGCTCATAGAAGTTCCTGTCCAGAGACCT
GTTCTCTATCCACAAGAGCAAGAAAATGAGCCATCCATCGGGGAGTTTAATGAGCAGGTT
CTGCGACTGATGCACAGCCTTGGAATAGATCAGCAGAAAACCATTGAGTCTTTGCAGAAC
AAGAGCTATAACCACTTTGCTGCCATTTATTTCTTGTTGGTGGAGCGCCTGAAATCACAT
CGGAGCAGTTTCCCAGTGGAGCAGAGACTTGATGGCCGCCAGCGTCGGCCTAGCACCATT
GCTGAGCAAACAGTTGCCAAGGCACAGACTGTGGGGCTCCCAGTGACCATGCATTCACCG
AACATGAGGCTGCTGCGATCTGCCCTCCTCCCCCAGGCATCCAACGTGGAGGCCTTTTCA
TTTCCAGCATCTGGCTGTCAGGCGGAAGCTGCATTCATGGAAGAAGAGTGTGTGGACACT
CCAAAGGTCAATGGCTGTCTGCTTGACCCTGTGCCTCCTGTCCTGGTGCGGAAGGGATGC
CAGTCACTGCCCAGCAACATGATGGAGACCTCCATTGACGAAGGGCTGGAGACAGAAGGA
GAGGCCGAGGAAGACCCCGCTCATGCCTTTGAGGCATTTCAGTCCACACGCAGCGGGCAG
AGACGGCACACTCTGTCAGAAGTGACCAATCAACTGGTCGTGATGCCTGGGGCAGGGAAA
ATTTTCTCCATGAATGACAGCCCCTCCCTTGACAGTGTGGACTCTGAGTATGATATGGGG
TCTGTTCAGAGGGACCTGAACTTTCTGGAAGACAACCCTTCCCTTAAGGACATCATGTTA
GCCAATCAGCCTTCACCCCGCATGACATCTCCCTTCATAAGCCTGAGACCTACCAACCCA
GCCATGCAGGCTCTGAGCTCCCAGAAACGAGAGGTCCACAACAGGTCTCCAGTGAGCTTC
AGAGAGGGCCGCAGAGCATCAGATACCTCCCTCACCCAGGGAATTGTAGCATTTAGACAA
CATCTTCAGAATCTGGCTAGAACCAAAGGAATTCTAGAGTTGAACAAAGTGCAGTTGTTG
TATGAACAAATAGGACCGGAGGCAGACCCTAACCTGGCGCCGGCGGCTCCTCAGCTCCAG
GACCTTGCTAGCAGCTGCCCTCAGGAAGAAGTTTCTCAGCAGCAGGAAAGCGTCTCCACT
CTCCCTGCCAGCGTGCATCCCCAGCTGTCCCCACGGCAGAGCCTGGAGACCCAGTACCTG
CAGCACAGACTCCAGAAGCCCAGCCTTCTGTCAAAGGCCCAGAACACCTGTCAGCTTTAT
TGCAAAGAACCACCGCGGAGCCTTGAGCAGCAGCTGCAGGAACATAGGCTCCAGCAGAAG
CGACTCTTTCTTCAGAAGCAGTCTCAACTGCAGGCCTATTTTAATCAGATGCAGATAGCA
GAGAGCTCCTACCCACAGCCAAGTCAGCAGCTGCCCCTTCCCCGCCAGGAGACTCCACCG
CCTTCTCAGCAGGCCCCACCGTTCAGCCTGACCCAGCCCCTGAGCCCCGTCCTGGAGCCT
TCCTCCGAGCAGATGCAATACAGCCCTTTCCTCAGCCAGTACCAAGAGATGCAGCTTCAG
CCCCTGCCCTCCACTTCCGGTCCCCGGGCTGCTCCTCCTCTGCCCACGCAGCTACAGCAG
CAGCAGCCGCCACCGCCACCACCCCCTCCACCACCACGACAGCCAGGAGCTGCCCCAGCC
CCCTTACAGTTCTCCTATCAGACTTGTGAGCTGCCAAGCGCTGCTTCCCCTGCGCCAGAC
TATCCCACTCCCTGTCAGTATCCTGTGGATGGAGCCCAGCAGAGCGACCTAACGGGGCCA
GACTGTCCCAGAAGCCCAGGACTGCAAGAGGCCCCCTCCAGCTACGACCCACTAGCCCTC
TCTGAGCTACCTGGACTCTTTGATTGTGAAATGCTAGACGCTGTGGATCCACAACACAAC
GGGTATGTCCTGGTGAATTAG
Chromosome Location
11
Locus
11q23.1
External Identifiers
ResourceLink
UniProtKB IDQ9H0K1
UniProtKB Entry NameSIK2_HUMAN
HGNC IDHGNC:21680
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails