Choline-phosphate cytidylyltransferase B
Details
- Name
- Choline-phosphate cytidylyltransferase B
- Synonyms
- 2.7.7.15
- CCT B
- CCT-beta
- CCTB
- CT B
- CTP:phosphocholine cytidylyltransferase B
- Phosphorylcholine transferase B
- Gene Name
- PCYT1B
- UniProtKB Entry
- Q9Y5K3Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0000986|Choline-phosphate cytidylyltransferase B MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADETNCQCQAPHE KLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHK FKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDD VYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRY RFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWK QMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASISS MSEGDEDEK
- Number of residues
- 369
- Molecular Weight
- 41939.76
- Theoretical pI
- 6.36
- GO Classification
- Functionsidentical protein binding / phosphatidylcholine bindingComponentsendoplasmic reticulum
- General Function
- Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis
- Specific Function
- choline-phosphate cytidylyltransferase activity
- Pfam Domain Function
- CTP_transf_like (PF01467)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010347|Choline-phosphate cytidylyltransferase B (PCYT1B) ATGGTAGGCCATCAGGAGTGCATCATGGAAGAGGACAATCGCGCTCCCCAATTGTGGCGC AAGACCCTGACTGCACCTGCCCCATTTGCTGATGAAACCAACTGCCAGTGTCAAGCACCC CATGAAAAACTGACCATTGCTCAGGCCCGCTTAGGAACACCAGCTGACAGGCCTGTCAGA GTATACGCCGATGGAATATTTGACCTCTTCCACTCAGGTCATGCAAGAGCCCTTATGCAA GCAAAAACACTGTTTCCCAACAGCTACTTGTTGGTAGGAGTTTGCAGTGATGATCTCACC CACAAATTCAAAGGTTTCACCGTGATGAATGAAGCCGAGAGATACGAAGCTCTCAGACAC TGTCGCTACGTAGACGAAGTTATCAGAGATGCTCCCTGGACACTCACGCCAGAGTTTCTG GAAAAACACAAGATTGACTTTGTGGCTCATGATGACATTCCGTATTCCTCTGCTGGCTCT GATGATGTTTACAAGCACATAAAGGAAGCAGGGATGTTCGTTCCAACGCAGAGAACAGAA GGCATCTCAACATCGGACATCATTACCAGAATTGTTCGTGACTATGATGTTTATGCCCGA CGTAACCTCCAGAGAGGGTATACAGCCAAGGAACTGAATGTCAGCTTTATAAATGAGAAG AGGTACCGTTTCCAGAACCAAGTGGACAAAATGAAGGAAAAAGTCAAGAATGTGGAGGAA AGATCAAAGGAATTTGTGAACAGAGTGGAAGAAAAGAGCCATGATCTAATTCAAAAGTGG GAAGAGAAGTCAAGGGAATTCATTGGCAACTTCCTAGAACTGTTTGGACCTGATGGAGCA TGGAAGCAGATGTTCCAGGAGAGGAGCAGCCGGATGCTGCAGGCCTTATCCCCGAAGCAG AGCCCTGTGAGCAGCCCAACCCGGAGCCGGTCCCCTTCCCGCTCCCCATCGCCCACCTTC TCATGGCTTCCACTCAAAACCTCACCCCCTTCCTCACCCAAAGCAGCCTCAGCCTCTATC AGCAGCATGAGCGAGGGGGATGAGGATGAAAAGTAG
- Chromosome Location
- X
- Locus
- Xp22.11
- External Identifiers
Resource Link UniProtKB ID Q9Y5K3 UniProtKB Entry Name PCY1B_HUMAN GenBank Protein ID 3153239 GenBank Gene ID AF052510 GeneCard ID PCYT1B GenAtlas ID PCYT1B HGNC ID HGNC:8755 KEGG ID hsa:9468 NCBI Gene ID 9468 - General References
- Lykidis A, Murti KG, Jackowski S: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. J Biol Chem. 1998 May 29;273(22):14022-9. [Article]
- Lykidis A, Baburina I, Jackowski S: Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. J Biol Chem. 1999 Sep 17;274(38):26992-7001. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Choline-phosphate cytidylyltransferase B (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Choline approved, nutraceutical unknown target product of Details Choline salicylate approved, nutraceutical unknown target product of Details Cholesterol approved, investigational yes target activator Details CT-2584 investigational yes target modulator Details Sphingosine experimental yes target inhibitor Details