Reaction: Clozapine to 1 product
- Reaction
- Reaction type
- N-demethylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Toth K, Csukly G, Sirok D, Belic A, Kiss A, Hafra E, Deri M, Menus A, Bitter I, Monostory K: Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics. Int J Neuropsychopharmacol. 2017 Jul 1;20(7):529-537. doi: 10.1093/ijnp/pyx019. [Article]
- Dragovic S, Gunness P, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN: Characterization of human cytochrome P450s involved in the bioactivation of clozapine. Drug Metab Dispos. 2013 Mar;41(3):651-8. doi: 10.1124/dmd.112.050484. Epub 2013 Jan 7. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 2C9 Not Available Not Available implied Cytochrome P450 2C19 Not Available Not Available implied Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available confirmed Cytochrome P450 3A5 Not Available Not Available implied
