Reaction: Desvenlafaxine to 1 product

Reaction
Reaction type
O-glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. DeMaio W, Cecelia K, Nichols A, Jordan R: Metabolism Studies of Desvenlafaxine Journal of Bioequivalence and Bioavailability. 2011 Jul 30;3(7):151-160. [Article]
  2. Calleja S, Zubiaur P, Ochoa D, Villapalos-Garcia G, Mejia-Abril G, Soria-Chacartegui P, Navares-Gomez M, de Miguel A, Roman M, Martin-Vilchez S, Abad-Santos F: Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine. Front Pharmacol. 2023 Feb 2;14:1110460. doi: 10.3389/fphar.2023.1110460. eCollection 2023. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-1Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 1-3Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 2B4Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 2B15Not AvailableNot Availableimplied
UDP-glucuronosyltransferase 2B17Not AvailableNot Availableimplied