Reaction: Desvenlafaxine to 1 product
- Reaction
- Reaction type
- O-glucuronidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- DeMaio W, Cecelia K, Nichols A, Jordan R: Metabolism Studies of Desvenlafaxine Journal of Bioequivalence and Bioavailability. 2011 Jul 30;3(7):151-160. [Article]
- Calleja S, Zubiaur P, Ochoa D, Villapalos-Garcia G, Mejia-Abril G, Soria-Chacartegui P, Navares-Gomez M, de Miguel A, Roman M, Martin-Vilchez S, Abad-Santos F: Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine. Front Pharmacol. 2023 Feb 2;14:1110460. doi: 10.3389/fphar.2023.1110460. eCollection 2023. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role UDP-glucuronosyltransferase 1-1 Not Available Not Available implied UDP-glucuronosyltransferase 1-3 Not Available Not Available implied UDP-glucuronosyltransferase 2B4 Not Available Not Available implied UDP-glucuronosyltransferase 2B15 Not Available Not Available implied UDP-glucuronosyltransferase 2B17 Not Available Not Available implied