Reaction: Morphine to 1 product
- Reaction
- Reaction type
- glucuronidation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
- Pacifici GM: Metabolism and pharmacokinetics of morphine in neonates: A review. Clinics (Sao Paulo). 2016 Aug;71(8):474-80. doi: 10.6061/clinics/2016(08)11. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role UDP-glucuronosyltransferase 2B7 Not Available Not Available confirmed UDP-glucuronosyltransferase 1-1 Not Available Not Available confirmed UDP-glucuronosyltransferase 1-8 Not Available Not Available implied UDP-glucuronosyltransferase 2B15 Not Available Not Available implied UDP-glucuronosyltransferase 2B4 Not Available Not Available implied UDP-glucuronosyltransferase 1-3 Not Available Not Available implied