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Ibutilide Action Pathway
smpdb.ca/view/SMP0000332Drug actionpotassium channel (I-Kur) open. … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Diltiazem Action Pathway
smpdb.ca/view/SMP0000359Drug actionpotassium channel (I-Kur) open. … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Sotalol Action Pathway
smpdb.ca/view/SMP0000660Drug actionThe electrophysiologic effects of sotalol may be due to its selective inhibition of the rapidly activating component of the potassium channel involved in the repolarization of cardiac cells.
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Acebutolol Action Pathway
smpdb.ca/view/SMP0000296Drug actionAcebutolol (also known as Sectral or Prent) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats (arrhythmias). Acebutolol al...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Penbutolol Action Pathway
smpdb.ca/view/SMP0000305Drug actionPenbutolol (also known as Levatol or Levatolol) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Penbutolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the b...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Carvedilol Action Pathway
smpdb.ca/view/SMP0000367Drug actionCarvedilol, trade name Coreg, is a nonselective beta-blocker that blocks both alpha and beta receptors of the heart and blood vessels. It is prescribed to treat hypertension, stable angina pectoris and congestive heart failure. Carvedilo...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Amlodipine Action Pathway
smpdb.ca/view/SMP0000376Drug actionAmlodipine, trade name Norvasc, is a dihydropyridine calcium channel blocker (CCB) prescribed to treat hypertension and exertion-related angina. The drug acts directly on vascular smooth muscle to cause peripheral vasodilation. Amlodipin...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Nitrendipine Action Pathway
smpdb.ca/view/SMP0000382Drug actionNitrendipine (also known as Bayotensin or Nidrel) is a dihydropyridine calcium channel blocker that may be used for treatment of hypertension. Nitrendipine binds the major channel in muscle cells: L-type calcium channels. Binding of nitr...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Bupranolol Action Pathway
smpdb.ca/view/SMP0000670Drug actionBupranolol is a nonselective beta-blocker with structural similarity to propanolol. Both drugs do not have intrinsic sympathomimetic activity. It competes with catecholamines for binding beta-1 adrenergic receptors in the heart to inhibi...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Digoxin Cardiac Action Pathway
smpdb.ca/view/SMP0125107Drug actionDigoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Digoxin is a positive inotropic and negative chronotropic drug, meaning that...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1