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Pyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125772DiseasePDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialLevofloxacin
go.drugbank.com/drugs/DB01137ApprovedInvestigational[A190663] It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin[A190663] and remains stereochemically stable following administration … Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin].
Categories: 4-Quinolones, MATE 1 InhibitorsSynonyms: (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid, (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acidOstrea edulis shell
go.drugbank.com/drugs/DB14251InvestigationalOstrea edulis shell is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.
Synonyms: European Flat Oyster Shell2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000549Diseaseoxoglutarate dehydrogenase complex (OGDC). … 2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialCardiolipin Biosynthesis (Barth Syndrome)
smpdb.ca/view/SMP0074684DiseaseA mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164).
Pyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000212DiseasePDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialMitochondrial Complex II Deficiency
smpdb.ca/view/SMP0000548DiseaseInterestingly, complex II deficiency gene mutation carriers may be at an increased risk for certain cancers. … Because complex II is found in the mitochondria, CII deficiency is technically considered a mitochondrial disease.
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialCopper gluconate Drug Metabolism
smpdb.ca/view/SMP0130548MetabolicCopper gluconate passes through the liver and is then excreted from the body mainly through the kidney. … Copper gluconate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Copper gluconate2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol
go.drugbank.com/drugs/DB08773ExperimentalSynonyms: Raloxifene core, 2-(4-hydroxyphenyl)benzo(b)thiophene-6-olAloe vera leaf
go.drugbank.com/drugs/DB13906ApprovedInvestigationalCommon active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose [A32475]. … It is a perennial succulent xerophyte with elongated leaves that contain a clear gel.
Synonyms: Barbatos aloe leafMixtures: Alcortin A, Alcortin A