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Displaying results 991 - 1000 of 10000 in total
  1. Target

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

    go.drugbank.com/bio_entities/BE0011403
    TargetHumans

    Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate … Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well (PubMed:12846830).

    Synonyms: Alkaline phosphodiesterase I, Phosphodiesterase I beta
  2. Target

    Intron-associated endonuclease 1

    go.drugbank.com/bio_entities/BE0002953
    TargetEnterobacteria phage T4

    This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.

    Synonyms: I-TevI
  3. Target

    Synapsin-1

    go.drugbank.com/bio_entities/BE0004488
    TargetHumans

    Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247,...

    Synonyms: Synapsin I
  4. Target

    Copine-1

    go.drugbank.com/bio_entities/BE0009002
    TargetHumans

    Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calc...

    Synonyms: Copine I
  5. Target

    Actin-1

    go.drugbank.com/bio_entities/BE0009170
    TargetPlasmodium falciparum (isolate HB3)

    Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes (By similarity).

    Synonyms: Actin I
  6. Target

    Progonadoliberin-1

    go.drugbank.com/bio_entities/BE0010526
    TargetHumans

    Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones

    Synonyms: Progonadoliberin I
  7. Target

    Tumor susceptibility gene 101 protein

    go.drugbank.com/bio_entities/BE0019070
    TargetHumans

    Component of the ESCRT-I complex, a regulator of vesicular trafficking process. … Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation.

    Synonyms: ESCRT-I complex subunit TSG101
  8. Drug

    Conjugated estrogens

    go.drugbank.com/drugs/DB00286
    ApprovedInvestigational

    Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble. … [T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: TROMODIL-V, PREMARIN CREMA V
  9. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

    go.drugbank.com/bio_entities/BE0000367
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). … Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371)

    Synonyms: Complex I-19kD, Complex I-PGIV
  10. Target

    Insulin-like growth factor 1

    go.drugbank.com/bio_entities/BE0003418
    TargetHumans

    Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. … The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

    Synonyms: IGF-I, Insulin-like growth factor I