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Displaying results 991 - 1000 of 10000 in total
  1. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 13

    go.drugbank.com/bio_entities/BE0009336
    EnzymeTargetHumans

    Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13
  2. Target

    C-type lectin domain family 12 member A

    go.drugbank.com/bio_entities/BE0010945
    TargetHumans

    Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).

    Polypeptides: C-type lectin domain family 12 member A
  3. Target

    2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

    go.drugbank.com/bio_entities/BE0000518
    TargetHumans

    Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA

    Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
  4. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 5

    go.drugbank.com/bio_entities/BE0003730
    TargetHumans

    Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11
  5. Drug

    Daptomycin

    go.drugbank.com/drugs/DB00080
    ApprovedInvestigational

    Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA … [A231384] Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed daptomycin; it was found that a once-daily dosing

    Categories: P-glycoprotein substratesProducts: CUBICIN® 350 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, CUBICIN® 500 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE
  6. Target

    Potassium voltage-gated channel subfamily A member 1

    go.drugbank.com/bio_entities/BE0000781
    TargetHumans

    Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception … In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).

    Polypeptides: Potassium voltage-gated channel subfamily A member 1
  7. Target

    HLA class I histocompatibility antigen, A alpha chain

    go.drugbank.com/bio_entities/BE0003483
    TargetHumans

    In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive … Antigen-presenting major histocompatibility complex class I (MHCI) molecule.

    Polypeptides: HLA class I histocompatibility antigen, A alpha chainSynonyms: HLA-A, MHC class I antigen A*3
  8. Target

    Potassium voltage-gated channel subfamily A member 7

    go.drugbank.com/bio_entities/BE0004719
    TargetHumans

    Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with

    Polypeptides: Potassium voltage-gated channel subfamily A member 7
  9. Target

    C-type lectin domain family 14 member A

    go.drugbank.com/bio_entities/BE0005467
    TargetHumans

    Polypeptides: C-type lectin domain family 14 member A
  10. Target

    Nuclear receptor subfamily 4 group A member 3

    go.drugbank.com/bio_entities/BE0008998
    TargetHumans

    by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. … During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity).

    Polypeptides: Nuclear receptor subfamily 4 group A member 3