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Rifaximin
go.drugbank.com/drugs/DB01220ApprovedInvestigationalsyndrome (IBS-D) in adult women and men. … Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: Rifamycin L 105, Rifamycin L 105SVAminophylline
go.drugbank.com/drugs/DB01223ApprovedInvestigationalOnce in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. … Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio.
Categories: Purinergic P1 Receptor Antagonists, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: อมิโนฟิลลีน 1 1/2 เกรน, DRAFILYN ZEnoxaparin
go.drugbank.com/drugs/DB01225ApprovedInvestigationalEnoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. … Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies.
Products: KLEXANE 10000 IE 100MG O S, CLEXANE TPemoline
go.drugbank.com/drugs/DB01230ApprovedIllicitWithdrawnIn 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.
Categories: Heterocyclic Compounds, 1-RingChloroxine
go.drugbank.com/drugs/DB01243ApprovedWithdrawnChloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 5,7-dichloro-8-quinolinol, 5,7-dichlor-8-hydroxychinolinDocetaxel
go.drugbank.com/drugs/DB01248ApprovedInvestigationalDocetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. … [A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and promote to cell death.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxelIodixanol
go.drugbank.com/drugs/DB01249ApprovedIodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the
Mixtures: BL-C KitCategories: X-Ray Contrast Activity, X-Ray Contrast Media, IodinatedRetapamulin
go.drugbank.com/drugs/DB01256ApprovedRetapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ALTARGO UNGUENTO 1%Desonide
go.drugbank.com/drugs/DB01260ApprovedInvestigationalA nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Mixtures: SPORUM-D, APOLAR NCategories: Corticosteroid Hormone Receptor Agonists, Cytochrome P-450 SubstratesDecitabine
go.drugbank.com/drugs/DB01262ApprovedInvestigationalFurther mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis. … Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one, 5-aza-2'-deoxycytidine