Chloroxine

DB01243ApprovedWithdrawnSmall molecule

Chloroxine is an antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.

Mechanism: Although the mechanism of action is not understood, chloroxine may slow down mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp. Chloroxine induces SOS-DNA repair in E. coli, so chloroxine may be genotoxic to bacteria.
Curator reviewed
Primary indication: Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.Curator reviewed · 11 structured indications
Formula / weight: C₉H₅Cl₂NO · 214.048 g/mol (avg)
First approval: United States, 2009
Also known as: 5,7-dichlorooxine · 5,7-dichloroxine · Chlorquinol
Code names: SQ 16401

Resolves to

Compound

UNII2I8BD50I8BCAS773-76-2ChEMBLCHEMBL1200596ChEBI59477PubChem2722KEGGD03472

Clinical / RWD

RxNorm20875PharmGKBPA164754879

Structure

InChIKeyWDFKMLRRRCGAKS-UHFFFAOYSA-NSMILESOC1=C(Cl)C=C(Cl)C2=C1N=CC=C2

Targets

P41145OPRK1

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Drug interactionsStructured to mechanism, not free text

11Structured indicationsCondition, population, route and combination as fields, not prose

11ContraindicationsEach with its own population and attribute set

9Marketed productsAcross 2 countries and 2 labellers

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Chloroxine, and which of those have an active Phase 3 trial?

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