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Displaying results 1001 - 1010 of 10000 in total
  1. Target

    Low affinity immunoglobulin gamma Fc region receptor III-A

    go.drugbank.com/bio_entities/BE0002097
    TargetHumans

    Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC

    Polypeptides: Low affinity immunoglobulin gamma Fc region receptor III-ASynonyms: IgG Fc receptor III-A
  2. Drug

    Flubendazole

    go.drugbank.com/drugs/DB08974
    ApprovedInvestigationalWithdrawn

    Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.

    Synonyms: methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate, (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl esterCategories: Heterocyclic Compounds, 2-Ring
  3. Indication

    Oral Malodor (Halitosis)

    go.drugbank.com/conditions/DBCOND0035973
    Drugs: Dequalinium
    Synonyms: Fetor ex ore, Foetor ex ore
  4. Drug

    Bivalirudin

    go.drugbank.com/drugs/DB00006
    ApprovedInvestigational

    Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.

    Products: ANGIOMAX® POLVO LIOFILIZADO PARA RECONSTRUIR A SOLUCIÓN INYECTABLE (50MG/ML), OBIVADIN 250 MG IV ENJEKSIYON/INFÜZYON IÇIN LIYOFILIZE TOZ, 1 ADET
  5. Target

    Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

    go.drugbank.com/bio_entities/BE0002256
    TargetEnzymeHumans

    ) and produce a new acyl-CoA. … Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate

    Polypeptides: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
  6. Target

    NKG2-A/NKG2-B type II integral membrane protein

    go.drugbank.com/bio_entities/BE0010560
    TargetHumans

    Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). … In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell

    Polypeptides: NKG2-A/NKG2-B type II integral membrane proteinSynonyms: NK cell receptor A, NKG2-A/B-activating NK receptor
  7. Drug

    Methotrexate

    go.drugbank.com/drugs/DB00563
    ApprovedInvestigational

    Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. … [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division.

    Synonyms: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, 4-amino-N(10)-methylpteroylglutamic acidCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  8. Drug

    Hyaluronidase

    go.drugbank.com/drugs/DB14740
    ApprovedInvestigational

    [A199026] Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue. … Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.

    Products: POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION PARA ADMINISTRACIÓN OFTALMICA, HYLASE® DESSAU 150 IU
  9. Drug

    Benzphetamine

    go.drugbank.com/drugs/DB00865
    ApprovedIllicit

    A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)

    Synonyms: (S)-(+)-N-benzyl-N,α-dimethylphenethylamine, d-N-methyl-N-benzyl-β-phenylisopropylamineCategories: Amphetamines, Cytochrome P-450 Substrates
  10. Drug

    Clostridium tetani toxoid antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB10583
    ApprovedInvestigational

    Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. … It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus.

    Mixtures: 3 ANTIGEN, Neisvac-CProducts: TETAVAX single dose, suspension for injection in a prefilled syringe, T-VAC 0,5 ML IM ENJEKSIYON IÇIN SÜSPANSIYON IÇEREN AMPUL