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Peptidoglycan editing factor PgeF
go.drugbank.com/bio_entities/BE0002757TargetEscherichia coli (strain K12)Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345).
Synonyms: S-methyl-5'-thioadenosine phosphorylase, S-methyl-5'-thioadenosine phosphorylase YfiHTransitional endoplasmic reticulum ATPase
go.drugbank.com/bio_entities/BE0004572TargetHumansNecessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to...
Synonyms: HEL-S-70Galectin-2
go.drugbank.com/bio_entities/BE0003247TargetHumansThis protein binds beta-galactoside. Its physiological function is not yet known
Synonyms: S-Lac lectin 2Migalastat
go.drugbank.com/drugs/DB05018ApprovedInvestigationala clinical benefit to patients. … [L47036,L47057,L4274,L4278] A further study is required to verify and describe the clinical benefits of Galafold, and the sponsor will be conducting a confirmatory clinical trial of Galafold in adults
Categories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones, Heterocyclic Compounds, 1-RingSynonyms: (2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 1-DeoxygalactostatinAldo-keto reductase family 1 member A1
go.drugbank.com/bio_entities/BE0004352TargetEnzymeHumansAlso acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). … Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity)
Synonyms: S-nitroso-CoA reductaseNavepegritide
go.drugbank.com/drugs/DB17824ApprovedInvestigational[L56065] Navepegritide was approved by the US FDA in February 2026 for use in patients 2 years of age and older with achondroplasia with open epiphyses.[L56058,L56065] … Achondroplasia, the most prevalent skeletal dysplasia, is caused by a gain-of-function variant in the fibroblast growth factor receptor 3 (FGFR3), which leads to overactive downstream signaling that inhibits
Primary Immune Deficiency Disorders (PIDD)
go.drugbank.com/conditions/DBCOND0038807Synonyms: Primary Immunodeficiency Disease(s)Nitric oxide synthase, inducible
go.drugbank.com/bio_entities/BE0000005TargetEnzymeHumansAlso has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). … As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity
Synonyms: Peptidyl-cysteine S-nitrosylase NOS2ATP-binding cassette sub-family C member 1
go.drugbank.com/bio_entities/BE0000785TargetTransporterHumansExports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. … Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231).
Synonyms: Glutathione-S-conjugate-translocating ATPase ABCC1Function: ABC-type glutathione S-conjugate transporter activityRalA-binding protein 1
go.drugbank.com/bio_entities/BE0004770TransporterHumansMultifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral...
Synonyms: Dinitrophenyl S-glutathione ATPaseFunction: ABC-type glutathione S-conjugate transporter activity