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Displaying results 1011 - 1020 of 1711 in total
  1. Target

    Tyrosine-protein phosphatase non-receptor type 12

    go.drugbank.com/bio_entities/BE0009940
    TargetHumans

    Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2...

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 12
  2. Target

    Tumor necrosis factor receptor superfamily member 6

    go.drugbank.com/bio_entities/BE0010463
    TargetHumans

    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor.

    Polypeptides: Tumor necrosis factor receptor superfamily member 6Synonyms: FASLG receptor
  3. Target

    Tumor necrosis factor receptor superfamily member 4

    go.drugbank.com/bio_entities/BE0010535
    TargetHumans

    Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity

    Polypeptides: Tumor necrosis factor receptor superfamily member 4Synonyms: OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor
  4. Target

    Tumor necrosis factor receptor superfamily member 10A

    go.drugbank.com/bio_entities/BE0010564
    TargetHumans

    Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor.

    Polypeptides: Tumor necrosis factor receptor superfamily member 10ASynonyms: Death receptor 4, TRAIL receptor 1
  5. Target

    Inactive tyrosine-protein kinase transmembrane receptor ROR1

    go.drugbank.com/bio_entities/BE0010828
    TargetHumans

    Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).

    Polypeptides: Inactive tyrosine-protein kinase transmembrane receptor ROR1Synonyms: Neurotrophic tyrosine kinase, receptor-related 1
  6. Target

    Macrophage scavenger receptor types I and II

    go.drugbank.com/bio_entities/BE0010942
    TargetHumans

    Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.

    Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Scavenger receptor class A member 1, Macrophage acetylated LDL receptor I and II
  7. Target

    Triggering receptor expressed on myeloid cells 2

    go.drugbank.com/bio_entities/BE0020451
    TargetHumans

    In dendritic cells, receptor of SEMA6D with PLEXNA1 as coreceptor and mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). … Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).

    Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2
  8. Target

    T cell receptor beta variable 5-6

    go.drugbank.com/bio_entities/BE0023691
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor beta variable 5-6
  9. Drug

    Avanafil

    go.drugbank.com/drugs/DB06237
    Approved

    In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively

  10. Drug

    Cangrelor

    go.drugbank.com/drugs/DB06441
    ApprovedInvestigational

    An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion therefore providing a rapid onset

    Categories: Purinergic P2 Receptor Antagonists, Purinergic P2Y Receptor Antagonists