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Metabolism and Physiological Effects of p-Cresol sulphate
smpdb.ca/view/SMP0126850MetabolicIn the gut mucosa and in the liver, the majority of p-cresol will be conjugated into the uremic toxin p-cresyl sulfate by aryl sulfotransferases (EC 2.8.2.1.). … , catalysed by p-hydroxyphenylpyruvate oxidase (EC 1.2.3.13.), and can subsequently lead to the formation of p-cresol by p-hydroxyphenylacetate decarboxylase.
Eltrombopag
go.drugbank.com/drugs/DB06210ApprovedInvestigationalITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. … Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based
Categories: Blood and Blood Forming OrgansProducts: Revolade Tablet 25mg, Revolade Tablet 50mgAmobarbital
go.drugbank.com/drugs/DB01351ApprovedIllicitA barbiturate with hypnotic and sedative properties (but not antianxiety). … Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Categories: Hypnotics and SedativesProducts: Amytal Sodium 500mg, Amytal Sodium Cap 60mgEftrenonacog alfa
go.drugbank.com/drugs/DB11608ApprovedEftrenonacog alfa was developed and marketed as Alprolix for intravenous injection by Biogen. It was first approved by the FDA in March 2014 and later approved by the EMA in May 2016. … It is an X-linked genetic disease caused by mutation of the gene for coagulation protein factor IX (FIX), leading to decreased levels of endogenous factor IX and increased susceptibility to recurrent bleeding
Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsSynonyms: Recombinant human coagulation factor IX, FC Fusion protein, Coagulation factor IX recombinant immunoglubulin g1 fusion proteinAntilymphocyte immunoglobulin (horse)
go.drugbank.com/drugs/DB09312ApprovedInvestigationalIt is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. … Induction of T cell apoptosis and resulting T-cell lymphopenia found in vivo is credited for its therapeutic effect in these conditions.
Categories: Fluids and Secretions, Amino Acids, Peptides, and ProteinsProducts: Atgam Sterile Solution IV 50mg/ml, ATGAM 50MG/ML STERILE SOLUTION (5ML AMP)Pentaerythritol tetranitrate
go.drugbank.com/drugs/DB06154ApprovedWithdrawnIt is formed by reacting pentaerythritol (C5H12O4), an alcohol commonly used in paints and varnishes, with nitric acid (HNO2). The reacting solution is chilled to precipitate the PETN. … It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina [L2395].
Categories: Vasodilators Used in Cardiac DiseasesProducts: Peritrate Tab 10mg, Peritrate Tab 20mgAmbrisentan
go.drugbank.com/drugs/DB06403ApprovedInvestigationalAs an endothelin receptor antagonist, Ambrisentan prevents endogenous endothelin peptide from constricting the muscles in blood vessels, allowing them to relax and permit a reduction in blood pressure. … It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening.
Categories: ambrisentan and tadalafilProducts: AMBRISEN 1A PHARMA 10MG, AMBRISENTAN ACCORD 10MGRiluzole
go.drugbank.com/drugs/DB00740ApprovedInvestigationalRiluzole is marketed as Rilutek by Sanofi. … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis.
Categories: Compounds used in a research, industrial, or household settingProducts: GLENTEK 50MG, RILUTEK 50MGExcitatory Neural Signalling Through 5-HTR 4 and Serotonin
smpdb.ca/view/SMP0000309SignalingAtrial heart receptors produce positive inotropy and tachycardia that can precipitate arrhythmias. … The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS.
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
smpdb.ca/view/SMP0000311SignalingThe 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep. … It is also speculated that this receptor may be involved in mood regulation.