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Displaying results 1021 - 1030 of 10000 in total
  1. Target

    Cytosolic non-specific dipeptidase

    go.drugbank.com/bio_entities/BE0018303
    EnzymeHumans

    N-[(S)-lactoyl]-L-phenylalanine is an exercise-induced metabolite that influences food intake and systemic energy balance (PubMed:25964343). … Upon physiological conditions of amino acids and lactate excess can also catalyze a reverse proteolysis reaction, generating N-[(S)-lactoyl]-L-phenylalanine and possibly other N-lactoyl-amino acids which

    Synonyms: HEL-S-13
  2. Target

    4-aminobutyrate aminotransferase GabT

    go.drugbank.com/bio_entities/BE0001510
    TargetEscherichia coli (strain K12)

    Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids. Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semia...

    Synonyms: (S)-3-amino-2-methylpropionate transaminase
  3. Drug

    Migalastat

    go.drugbank.com/drugs/DB05018
    ApprovedInvestigational

    a clinical benefit to patients. … [L47036,L47057,L4274,L4278] A further study is required to verify and describe the clinical benefits of Galafold, and the sponsor will be conducting a confirmatory clinical trial of Galafold in adults

    Synonyms: (2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 1-DeoxygalactostatinCategories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones, Heterocyclic Compounds, 1-Ring
  4. Target

    Alcohol dehydrogenase class-3

    go.drugbank.com/bio_entities/BE0000009
    TargetEnzymeHumans

    Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity) … Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164).

    Synonyms: S-(hydroxymethyl)glutathione dehydrogenase
  5. Target

    Myosin regulatory light chain 12A

    go.drugbank.com/bio_entities/BE0004293
    TargetHumans

    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)

    Synonyms: HEL-S-24
  6. Drug

    Navepegritide

    go.drugbank.com/drugs/DB17824
    ApprovedInvestigational

    [L56065] Navepegritide was approved by the US FDA in February 2026 for use in patients 2 years of age and older with achondroplasia with open epiphyses.[L56058,L56065] … Achondroplasia, the most prevalent skeletal dysplasia, is caused by a gain-of-function variant in the fibroblast growth factor receptor 3 (FGFR3), which leads to overactive downstream signaling that inhibits

  7. Target

    2-Hydroxyacid oxidase 2

    go.drugbank.com/bio_entities/BE0004577
    TargetEnzymeHumans

    Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the corresponding 2-oxoacids (PubMed:10777549). Its role in the oxidation of 2-hydroxy fatty acids may c...

    Synonyms: (S)-2-hydroxy-acid oxidase, peroxisomalFunction: (S)-2-hydroxy-acid oxidase activity
  8. Drug

    Inositol nicotinate

    go.drugbank.com/drugs/DB08949
    ApprovedWithdrawn

    Inositol nicotinate is prescribed in Europe under the name Hexopal as a symptomatic treatment for severe intermittent claudication and Raynaud’s phenomenon. … It is associated with reduced flushing compared to other vasodilators by being broken down into the metabolites and inositol at a slower rate.

    Mixtures: TL-Care DHACategories: Vitamin B Complex, Heterocyclic Compounds, 1-Ring
  9. Target

    Nitric oxide synthase

    go.drugbank.com/bio_entities/BE0010197
    TargetEnzyme

    Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR … Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity).

    Synonyms: Peptidyl-cysteine S-nitrosylase NOS1, Peptidyl-cysteine S-nitrosylase NOS2
  10. Target

    Cyclopropane mycolic acid synthase 1

    go.drugbank.com/bio_entities/BE0003738
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.

    Synonyms: S-adenosylmethionine-dependent methyltransferase