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CAI-1 autoinducer synthase
go.drugbank.com/bio_entities/BE0004287TargetVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal.
Polypeptides: CAI-1 autoinducer synthaseFluconazole
go.drugbank.com/drugs/DB00196ApprovedInvestigationalIt was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. … Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues.
Mixtures: Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4%, KADMIZOL®-FCategories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsDaptomycin
go.drugbank.com/drugs/DB00080ApprovedInvestigational[A231384] Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed daptomycin; it was found that a once-daily dosing … [A231379] Daptomycin was approved by the FDA on September 12, 2003, and is marketed under the name CUBICIN® by Cubist Pharmaceuticals LLC (Merck & Co.).[L32534]
Categories: P-glycoprotein substratesProducts: CUBICIN® 350 MG POLVO PARA SOLUCIÓN INYECTABLE O INFUSIÓN, CUBICIN® 500 MG POLVO PARA SOLUCION INYECTABLE O INFUSIONPotassium citrate
go.drugbank.com/drugs/DB09125ApprovedInvestigationalVet approvedIt contains 38.3% potassium by mass. In the monohydrate form it is highly hygroscopic and deliquescent. Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis. … Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste.
Mixtures: Formula No. 2 Plus K Liq, Cal-mag (one To One) With Potass & ZincProducts: U-ALKALIZER POTASSIUM CITRATE MIXTURE, Urocit-KAxicabtagene ciloleucel
go.drugbank.com/drugs/DB13915ApprovedInvestigational[L40054] The development of resulted from early preclinical studies conducted by a group of researchers at the National Cancer Institute (NCI), who demonstrated that T cells expressing an anti-CD19 CAR … Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy.
Categories: Antigens, Differentiation, B-Lymphocyte, Genetically-modified Autologous T CellsSynonyms: Autologous T cells transduced with retroviral vector encoding an anti-CD-19 CD28/CD3-zeta chimeric antigen receptorFatty acid synthase
go.drugbank.com/bio_entities/BE0000959TargetEnzymeHumansFatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 cata...
Synonyms: Type I fatty acid synthaseSemenogelin-1
go.drugbank.com/bio_entities/BE0005833TargetHumansPredominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the ...
Synonyms: Semenogelin IS-adenosylmethionine synthase isoform type-1
go.drugbank.com/bio_entities/BE0000407TargetEnzymeHumansCatalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis ...
Synonyms: MAT-I/III, Methionine adenosyltransferase I/IIINADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
go.drugbank.com/bio_entities/BE0000473TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-13kD-B, Complex I subunit B13NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
go.drugbank.com/bio_entities/BE0000500TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-AQDQ, Complex I-18 kDa