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Ambrisentan
go.drugbank.com/drugs/DB06403ApprovedInvestigationalIn addition, it is approved in the United States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and to improve exercise ability. … As an endothelin receptor antagonist, Ambrisentan prevents endogenous endothelin peptide from constricting the muscles in blood vessels, allowing them to relax and permit a reduction in blood pressure.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acidAbciximab
go.drugbank.com/drugs/DB00054ApprovedWithdrawnIt also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.
Products: CLOTİNAB 10 MG/5 ML IV ENJEKSİYON İÇİN ÇÖZELTİ İÇEREN FLAKON, 1 ADET, ReoPro 2 mg/ml Injektionslösung oder InfusionslösungDexrazoxane
go.drugbank.com/drugs/DB00380ApprovedInvestigationalWithdrawn[PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. … An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione, (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propaneMepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalThis indication was subsequently expanded to cover EGPA on December 12, 2017, and HES on September 25, 2020.[L16518] … Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum
Products: Nucala 40 mg/0,4 mL S.C. Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (1 adet), Nucala 40 mg/0,4 mL S.C. Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (3 adet)Acylcarnitine (5Z,8Z)-10-[(2S,3R)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl]deca-5,8-dienoylcarnitine
smpdb.ca/view/SMP0123546Metabolic(5Z,8Z)-10-[(2S,3R)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl]deca-5,8-dienoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (5Z,8Z)-10-[(2S,3R)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl]deca-5,8-dienoyl-CoA reacts with L-carnitine to form (5Z,8Z)-10-[(2S,3R)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl]
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigational[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214] … Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic
Categories: Heterocyclic Compounds, 2-RingSynonyms: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurineOrnidazole
go.drugbank.com/drugs/DB13026InvestigationalOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
Mixtures: ORNISASIN 500 MG/500 MG FILM TABLET, 10 ADET, ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADETCategories: Heterocyclic Compounds, 1-RingModafinil
go.drugbank.com/drugs/DB00745ApprovedInvestigationalThe exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular … Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy.
Synonyms: 2-((diphenylmethyl)sulfinyl)acetamideProducts: CRALİUM 200 MG TABLET, 30 ADET, MODIWAKE 200 MG TABLET, 30 ADETPerazine
go.drugbank.com/drugs/DB12710ApprovedWithdrawnPerazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Products: PERAZIN-NEURAX 100 MG, PERAZIN-NEURAX 200 MGCimetidine
go.drugbank.com/drugs/DB00501ApprovedInvestigationalIt also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Synonyms: N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine, N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidineInternational brands: Tagamet HB 200